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1.
Photobiomodul Photomed Laser Surg ; 41(1): 17-25, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36629903

RESUMO

Objective: To assess the effects of intense pulsed light (IPL) on oxidative stress (OS) in perennial allergic conjunctivitis (PAC). Background: IPL treatment has been proven effective for dry eye disease (DED). However, we have observed that, after IPL treatment, some patients with DED combined with allergic conjunctivitis (AC), an immune response condition in which excessive OS causes and exacerbates inflammatory damage, not only show an improvement in eye dryness, but also their AC-related eye itching is relieved. The mechanism by which IPL inhibits allergic reactions is not clear. Methods: Five patients with moderate-to-severe PAC were given two IPL treatments on the periorbital skin with a 2-week interval. Visual analog scale (VAS) scores and signs of AC, including eye redness and conjunctival follicles, were assessed before the first treatment (day 1) and 2 weeks after the second treatment (day 30). Tears were also collected at the same time, and lipid oxidation (LPO) metabolite analysis was performed using liquid chromatography tandem mass spectrometry (LC-MS/MS) to investigate the effects of IPL on OS response. Results: The average VAS score significantly decreased with treatment (30.2 for day 1, 10.6 for day 30; p < 0.001). The general signs of PAC showed no difference (p > 0.05). LPO metabolite analysis revealed that 17,18-diHETE, which is an oxidation product of eicosapentaenoic acid, and 13-OXoODE, which is an oxidation product of linoleic acid, are significantly downregulated after IPL treatment. Conclusions: The photothermal effect of IPL attenuates OS in PAC, and this seems to be one of the mechanisms by which IPL treatment improves PAC. Clinical Trial Registration number: ChiCTR1900022202.


Assuntos
Conjuntivite Alérgica , Síndromes do Olho Seco , Terapia de Luz Pulsada Intensa , Humanos , Conjuntivite Alérgica/tratamento farmacológico , Cromatografia Líquida , Espectrometria de Massas em Tandem , Síndromes do Olho Seco/terapia , Terapia de Luz Pulsada Intensa/métodos
2.
Photobiomodul Photomed Laser Surg ; 40(10): 715-727, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36286576

RESUMO

Objective: To assess the inhibitory effects of intense pulsed light (IPL) on meibomian gland (MG) inflammation. Background: IPL treatment is effective for dry eye disease (DED) caused by meibomian gland dysfunction (MGD). However, the anti-inflammatory and regeneration stimulating effects of IPL on MGD remain unclear. Moreover, studies on inflammatory metabolites in MG secretions are lacking. Methods: Six patients with DED were administered two IPL treatments. Ocular surface disease index (OSDI) questionnaires were used to assess DED, MGD signs, including degree of obstruction, secretion, and atrophy of the MG, tear film break-up time (TBUT) was assessed before and after treatments. To determine IPL treatment-induced changes in metabolites, liquid chromatography tandem mass spectrometry (LC-MS/MS) was used to analyze MG secretions. Results: Data were gathered before the first treatment (time A) and 2 weeks after the second treatment (time B). Average OSDI score showed a significant decrease (time A and B measurements were 44.07 and 16.65, respectively). Besides, statistically significant differences were observed in MG signs before and after treatments: degree of obstruction improved and secretions became thinner. TBUT was significantly increased to the normal range. LC-MS/MS led to the identification of 53 differential metabolites: 23 were upregulated (e.g., estradiol, coenzyme Q, and azelaic acid) and 30 were downregulated (e.g., prostaglandins, 20-hydroxyeicosatetraenoic acid, and arachidonic acid). Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that most differential metabolites were involved in steroid hormone biosynthesis. Conclusions: Periorbital IPL treatment can improve chronic inflammation of the MG and promote its normal secretion. The steroid hormone biosynthetic pathways may be activated to participate in this anti-inflammatory effect.


Assuntos
Terapia de Luz Pulsada Intensa , Disfunção da Glândula Tarsal , Humanos , Glândulas Tarsais , Terapia de Luz Pulsada Intensa/métodos , Cromatografia Líquida , Ácido Araquidônico/metabolismo , Ubiquinona/metabolismo , Fototerapia/métodos , Espectrometria de Massas em Tandem , Inflamação , Prostaglandinas/metabolismo , Estradiol/metabolismo
4.
Artigo em Inglês | MEDLINE | ID: mdl-34394383

RESUMO

OBJECTIVE: To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR). METHODS: The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes. Cytoscape was used to construct and analyze network DR and LDD's network, and DAVID was used for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were carried out to verify the results of systematic pharmacology. RESULTS: Five networks were constructed and analyzed: (1) diabetic retinopathy genes' PPI network; (2) compound-compound target network of LDD; (3) LDD-DR PPI network; (4) compound-known target network of LDD; (5) LDD known target-DR PPI network. Several DR and treatment-related targets, clusters, signaling pathways, and biological processes were found. Animal experiments found that LDD can improve the histopathological changes of the retina. LDD can also increase erythrocyte filtration rate and decrease the platelet adhesion rate (P < 0.05) and decrease MDA and TXB2 (P < 0.05). Compared with the model group, the retinal VEGF and HIF-1α expression in the LDD group decreased significantly (P < 0.05). CONCLUSION: The therapeutic effect of LDD on DR may be achieved by interfering with the biological processes (such as response to insulin, glucose homeostasis, and regulation of angiogenesis) and signaling pathways (such as insulin, VEGF, HIF-1, and ErbB signaling pathway) related to the development of DR that was found in this research.

5.
Photobiomodul Photomed Laser Surg ; 39(3): 196-203, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33625273

RESUMO

Objective: To conduct a preliminary assessment of intense pulsed light (IPL) treatment for allergic keratoconjunctivitis (AKC)-associated ocular itch. Background: Current control measures for AKC rely primarily on drugs. IPL is effective for dry eye disease (DED). Furthermore, phototherapy is effective for managing skin inflammation and pruritus, suggesting that eye itching could decrease in some patients having AKC complicated with DED following IPL treatment to control dry eye symptoms. Methods: Thirty-five patients having DED complicated with mid-to-severe AKC were administered three IPL treatments to the periorbital skin. The eye scores of subjective symptoms and signs of AKC and tear film breakup time (TBUT) were retrospectively assessed before and after each treatment. Results: The scores for AKC-related symptoms and signs were determined four times: on Day 1 (time 0), Day 15 (time 1), Day 45 (time 2), and Day 75 (time 3) before each treatment. The average symptom score significantly decreased with treatments (time 0: 30.97, time 1: 15.03, time 3: 10). The average sign score for both eyes decreased after the first IPL treatment (left eye: 7.97 vs. 11.38; right eye: 8.1 vs. 11.1). There were no further improvements in the signs after the last treatment. The TBUT value in the right eye increased from times 0 to 3 (2.31 vs. 4.66 vs. 7.71 vs. 7.74). The TBUT value in the left eye increased from times 0 to 3 (2.50 vs. 6.97 vs. 7.57 vs. 8.24). Conclusions: Symptoms and signs improved after IPL treatment in patients with AKC. Eye itching was gradually controlled and rarely recurred. IPL may be effective for AKC treatment.


Assuntos
Síndromes do Olho Seco , Ceratoconjuntivite , Humanos , Ceratoconjuntivite/complicações , Ceratoconjuntivite/terapia , Fototerapia , Prurido/etiologia , Prurido/terapia , Estudos Retrospectivos
6.
Photobiomodul Photomed Laser Surg ; 38(4): 249-254, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32301670

RESUMO

Objective: To conduct a preliminary assessment of the intense pulsed light (IPL) treatment on the upper eyelid. Background: IPL therapy is an effective therapy for meibomian gland dysfunction (MGD). The normal treatment region includes the skin below the lower eyelids and both temporal parts, but not the upper eyelid. Methods: Thirty patients with mid-to-severe dry eye disease caused by MGD were selected and randomly divided into two groups. Fifteen controls in group A received normal IPL treatment. Fifteen patients in Group B underwent additional IPL treatment on the upper eyelid. The change in noninvasive tear breakup time (BUT), Ocular Surface Disease Index (OSDI) questionnaire, patient satisfaction, and adverse events were measured and recorded at each visit, before each treatment. Results: The dry eye symptoms of the patients in both groups improved. The patients in group B had better recovery than those in group A: BUT (right eye: 11.6 ± 3.67 sec vs. 7.73 ± 1.99 sec; left eye: 12.73 ± 4.19 sec vs. 7.73 ± 1.40 sec), OSDI (8.87 ± 4.31 vs. 14.93 ± 3.47); patient satisfaction in group B remained good, but decreased in group A with prolonged treatment duration. No serious skin and eye complications were found in any patient. Conclusions: This study showed the patients who received IPL treatment on the upper eyelid experienced improved symptoms of MGD. A further long-term study should be conducted to increase our understanding of the effect of expanded IPL treatment.


Assuntos
Síndromes do Olho Seco/terapia , Terapia de Luz Pulsada Intensa , Disfunção da Glândula Tarsal/terapia , Adulto , China , Síndromes do Olho Seco/etiologia , Duração da Terapia , Feminino , Humanos , Masculino , Disfunção da Glândula Tarsal/complicações , Pessoa de Meia-Idade , Satisfação do Paciente , Resultado do Tratamento
7.
Photobiomodul Photomed Laser Surg ; 37(2): 70-76, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31050931

RESUMO

Background and objective: Several cases of meibomian gland dysfunction (MGD), particularly the moderate to severe ones, are considered intractable by traditional therapy. Intense pulsed light (IPL) therapy has emerged as a new choice for management of MGD in recent years, given that use of lasers and optical treatments is typically challenging in patients with darker skin types. Methods: IPL treatment for MGD is administered in the periorbital area with the thinnest skin in our body, which has an inherent risk of skin side effects. We evaluated the effects and safety of this therapy in Chinese patients with Fitzpatrick skin types III-IV. Forty MGD patients were randomly administered IPL treatment with two types of parameters in the left and the right eye. Results: Results revealed that both parameter settings of IPL treatment could gradually and effectively raise the tear breakup time (BUT) and ocular surface disease index (OSDI) score. However, younger patients showed better improvement in BUT (F = 19.54, p < 0.01) and OSDI (F = 9.93, p < 0.01) compared with older patients. Conclusions: Overall, results showed that IPL treatment is safe and effective in MGD patients with skin types III-IV.


Assuntos
Povo Asiático , Terapia de Luz Pulsada Intensa , Disfunção da Glândula Tarsal/terapia , Pigmentação da Pele , Adulto , Fatores Etários , China , Feminino , Humanos , Masculino , Disfunção da Glândula Tarsal/etnologia , Pessoa de Meia-Idade , Resultado do Tratamento
8.
Photobiomodul Photomed Laser Surg ; 37(4): 244-247, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31050954

RESUMO

Objective: Ultrapulse CO2 laser has been used for several decades for removal of xanthelasma lesions. However, most studies to date have focused on Caucasian patients (skin types I-II). We sought to assess the efficacy and complications of CO2 laser therapy for xanthelasma palpebrarum (XP) in Chinese patients (skin types III-IV). Methods: Data of 38 patients with xanthelasma who received CO2 laser treatment between December 2013 and January 2016 at our hospital were retrospectively analyzed. Patients were followed up for 9 months. Results: Recurrence occurred in 19/38 (50%) patients. Recurrence was significantly more common in patients with multiple lesions (15/24; 62.5%) than in patients with single lesions (4/14; 28.6%). At 3 months after treatment, the complication rate was 63.16%. The complications included hypopigmentation (23/24; 95.8%) and scarring (1/24; 4.2%). In all patients, the hypopigmentation had disappeared by end of the 9-month follow-up. Conclusions: Ultrapulse CO2 laser appears to be capable of completely removing XP in patients with medium skin type III-IV. The most common complication is hypopigmentation, but this resolves with time.


Assuntos
Pálpebras/efeitos da radiação , Lasers de Gás/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Xantomatose/radioterapia , Adulto , Idoso , Dióxido de Carbono , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
9.
J Cosmet Laser Ther ; 20(3): 168-178, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29236557

RESUMO

OBJECTIVE: Laser skin resurfacing (LSR) has been used for facial rejuvenation for the last 20 years. Posttreatment care after LSR is essential to decrease the risk of complications. Currently, no unified standards or criteria exist for invasive LSR posttreatment care. We aimed to identify the optimal wound care timing and choice of specific local, systemic, and general medical measures required to decrease complications. METHODS: We performed a systematic search of the PubMed/MEDLINE electronic databases and included only articles written and published in the English language, with no restrictions on the publication time (year). RESULTS: The search yielded 316 potentially relevant articles, 133 of which met our review criteria. Most of the studies on this topic have focused on wound care during the early stage, typically the first 2 weeks. Closed dressings may offer a more ideal, moist wound environment. The use of medications must be judicious. The ongoing emergence of new methods and products warrants evaluation in future large clinical trials. SUMMARY: Familiarity with the complications following invasive LSR and the provision of optimal, effective, and timely posttreatment care may substantially decrease the risks associated with the treatment modality.


Assuntos
Terapia com Luz de Baixa Intensidade/efeitos adversos , Terapia com Luz de Baixa Intensidade/métodos , Envelhecimento da Pele/efeitos da radiação , Ferimentos e Lesões/terapia , Antibioticoprofilaxia , Bandagens , Colágeno/metabolismo , Técnicas Cosméticas , Elastina/metabolismo , Fator de Crescimento Epidérmico/uso terapêutico , Humanos , Hidroquinonas/uso terapêutico , Lasers de Gás/efeitos adversos , Lasers de Estado Sólido/efeitos adversos , Melanócitos/metabolismo , Plasma Rico em Plaquetas/metabolismo , Rejuvenescimento , Índice de Gravidade de Doença , Pele/fisiopatologia , Fatores de Tempo , Cicatrização/fisiologia , Ferimentos e Lesões/etiologia , Ferimentos e Lesões/fisiopatologia
10.
Photomed Laser Surg ; 34(10): 435-447, 2016 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-27697004

RESUMO

BACKGROUND: For 20 years, intense pulsed light (IPL) technology has been used to treat various medical problems. IPL has since developed rapidly, becoming popular among patients worldwide. Recently, IPL has been used mainly for cosmetic purposes. Researchers are constantly seeking new applications of IPL to meet the increasing needs of patients. OBJECTIVE: This review summarizes the development of IPL devices, discusses the current literature on the clinical application of IPL to increase our understanding of IPL, and provides guidance for broadening its clinical applications. MATERIALS AND METHODS: We performed a systematic search of electronic databases, including MEDLINE and PubMed and the authors experience on IPL to divide IPL development into three stages: germination, growth, and relative maturity. RESULTS: Studies established the classical indications of IPL, including vascular lesions, pigmented lesions, hair growth, and photo rejuvenation. However, trials showed IPL has limited effects for complicated skin problems. Many studies explored rational combination therapies by IPL and laser or other cosmetic technologies. CONCLUSIONS: Based on previous research and the new generation of IPL devices, in the future, we predict wider and more effective clinical applications of IPL through the further improvement of IPL devices and their combined treatment.


Assuntos
Terapia de Luz Pulsada Intensa , Humanos , Terapia de Luz Pulsada Intensa/métodos
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