RESUMO
Acute lung injury (ALI) is a clinically common critical disease with various treatment methods. Stem cell has drawn great attention for excellent performance in treatment of ALI. However, due to its high apoptosis rate, the further clinical application of stem cell is restricted. Exosomes are a kind of extracellular vesicles secreted by cells, which play important role in injury repair with further research about exosomes. This article reviews current situation, brief introduction to exosomes, repair effects of exosomes on ALI, and the potential signal pathway.
Assuntos
Lesão Pulmonar Aguda/metabolismo , Apoptose/efeitos dos fármacos , Exossomos/metabolismo , Lesão Pulmonar Aguda/diagnóstico , Terapia Biológica , Humanos , Medicina de Precisão , Transdução de Sinais , Células-TroncoRESUMO
6-Aminohexyl alpha-D-galactopyranosyl-(1-->4)-beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranoside (2), a globotriose analogue with a functionalized aglycon, was synthesized, using alpha-D-galactopyranosyluronic acid-(1-->4)-D-galactopyranosyluronic acid [di-GalA (3)] as the starting material, which is commercially available or can be readily prepared from pectin.
Assuntos
Trissacarídeos/síntese química , Sequência de Carboidratos , Cromatografia em Camada Fina , Isomerismo , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , PectinasRESUMO
Two new compounds were isolated from the roots of Polygala arillata Buch-Ham. On the basis of chemical reactions and spectral (UV, IR, MS, 1HNMR, DIFNOE, 13CNMR) analysis, they were identified as 1,3-dihydroxy-2-methoxyxanthone(I) and 7-hydroxy-1-methoxy-2,3-methylenedioxyxanthone(II). Pharmacological study indicated that I and II have inhibitory effect on aldose reductase activity.