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Int J Med Mushrooms ; 24(11): 63-71, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36374949

RESUMO

Wild edible mushrooms are a huge source to discover bioactive natural products. In this work, one new polyprenylphenol derivative, termed 2-geranylgeranyl-1,4-benzenediol 1-O-acetate (1), together with eight known compounds (2-9) were isolated from wild edible mushroom Suillus luteus. The structure of new compound was elucidated by high-resolution electrospray ionization mass spectroscopy and nuclear magnetic resonance data. The structures of known compounds were elucidated by comparison of their nuclear magnetic resonance data with literature data. Compounds 1-7 exhibited significant 2,2-diphenyl-1-picrylhydrazyl free radical scavenging activity with IC50 values ranging from 1.55 ± 0.29 to 19.89 ± 2.28 µM. In addition, compounds 1-7 also showed tyrosinase inhibitory activity with IC50 values ranging from 21.97 ± 3.74 to 66.26 ± 6.85 µM.


Assuntos
Agaricales , Basidiomycota , Agaricales/química , Sequestradores de Radicais Livres/farmacologia , Sequestradores de Radicais Livres/química , Espectrometria de Massas por Ionização por Electrospray , Estrutura Molecular , Antioxidantes/farmacologia , Antioxidantes/química
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