RESUMO
To investigate the effect of drugs other than metronidazole, 3 non-pregnant women infected with Trichomonas vaginalis were treated with doxycycline, 2 x 200 mg/day for 1 week. Another 3 women were treated with praziquantel, single dose, 40 mg/kg body weight. No therapeutic effect was detected for either drug. In vitro, oxytetracycline led to death of T. vaginalis at a concentration of 15 mg in 0.5 mL medium. Extract of Myrtus communis caused death of T. vaginalis at pH 4.65, but failed to do so at pH 6.00. Extract of Eucalyptus comaldensis (50 mg in 0.1 mL medium) at pH 5.35 caused death of T. vaginalis after 24 hours.
Assuntos
Anti-Infecciosos/uso terapêutico , Doxiciclina/uso terapêutico , Eucalyptus , Myrtus , Oxitetraciclina/uso terapêutico , Fitoterapia/métodos , Praziquantel/uso terapêutico , Vaginite por Trichomonas/tratamento farmacológico , Adulto , Animais , Anti-Infecciosos/provisão & distribuição , Antitricômonas/uso terapêutico , Esquema de Medicação , Avaliação Pré-Clínica de Medicamentos , Feminino , Humanos , Concentração de Íons de Hidrogênio , Iraque , Metronidazol/uso terapêutico , Pessoa de Meia-Idade , Extratos Vegetais/uso terapêutico , Fatores de Tempo , Resultado do Tratamento , Vaginite por Trichomonas/diagnóstico , Vaginite por Trichomonas/parasitologia , Trichomonas vaginalis/efeitos dos fármacosRESUMO
To investigate the effect of drugs other than metronidazole, 3 non- pregnant women infected with Trichomonas vaginalis were treated with doxycycline, 2x200 mg/ day for 1 week. Another 3 women were treated with praziquantel, single dose, 40 mg/ kg body weight. No therapeutic effect was detected for either drug. In vitro, oxytetracycline led to death of T. vaginalis at a concentration of 15 mg in 0.5 mL medium. Extract of Myrtus communis caused death of T. vaginalis at pH 4.65, but failed to do so at pH 6.00. Extract of Eucalyptus comaldensis [50 mg in 0.1 mL medium] at pH 5.35 caused death of T. vaginalis after 24 hours