RESUMO
The experiments carried out on the model of immobilization stress permit establishing the antiulcer effect of preventive introduction of sodium succinate solution, milk serum solution and solution of milk serum with sodium succinate. A decrease in the degree and number of ulcers and in the integrative indices characterizing the ulcer process after introduction of the studied drugs was accompanied by a fall of the intensity of lipid peroxidation processes.
Assuntos
Antiulcerosos/uso terapêutico , Úlcera Gástrica/prevenção & controle , Estresse Psicológico/complicações , Succinatos/uso terapêutico , Animais , Avaliação Pré-Clínica de Medicamentos , Quimioterapia Combinada , Peroxidação de Lipídeos/efeitos dos fármacos , Ratos , Ratos Wistar , Restrição Física , Soluções , Úlcera Gástrica/etiologia , Úlcera Gástrica/metabolismo , Estresse Psicológico/metabolismo , Ácido SuccínicoRESUMO
Ultrastructural changes of myocardium cells, neurons of sensorimotor cerebral cortex, endothelium of blood microvessels were registered by transmissive electron microscopy in mice receiving rock balm preparations per os. Both stimulating and toxic effects were observed dependently on used concentrations. This necessitates dosage to be strictly observed.
Assuntos
Coração/efeitos dos fármacos , Córtex Motor/efeitos dos fármacos , Miocárdio/ultraestrutura , Resinas Vegetais/farmacologia , Animais , Relação Dose-Resposta a Droga , Ventrículos do Coração/efeitos dos fármacos , Ventrículos do Coração/ultraestrutura , Substâncias Húmicas , Masculino , Camundongos , Microscopia Eletrônica , Minerais , Córtex Motor/ultraestrutura , Resinas Vegetais/toxicidade , Estimulação QuímicaRESUMO
The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.