1.
Drug Dev Ind Pharm
; 26(1): 79-83, 2000 Jan.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10677813
RESUMO
An experimental investigation into the use of a hydrophobic matrix to control the release of a highly water soluble drug was undertaken. Matrices consisting of hydrogenated vegetable oil and calcium sulfate with a 4% drug loading showed a sustained-release profile of up to 24 hr. The release mechanism from such matrices seemed to obey both root time kinetics and first-order behavior. Investigations showed that the effect of geometry had a significant effect on the drug release rate.