[Morphohistochemical and electron microscopic characteristics of malignant tumors of the upper respiratory tract after combined local hyperthermia and radiotherapy]. / Morfogistokhimicheskaia i élektronno-mikroskopicheskaia kharakteristika zlokachestvennykh opukholei verkhnikh dykhatel'nykh putei pri sochetanii lokal'noi gipertermii i luchevoi terapii.

The paper discusses morphohistochemical and electron microscopic characteristics of 15 primary tumors of the upper respiratory tract removed following preoperative irradiation in combination with local hyperthermia as a radio-modifying factor. Eighteen tumors removed after irradiation alone served as controls. Application of local microwave hyperthermia resulted in a higher degree of irreversible tumor cell dystrophia and damage. Hyperthermia--induced damage included disorders in ultrastructure of intracellular membranes and cell organelles mainly due to derangement of membrane--binding proteins, protein--lipid and nucleotide complexes. Thermoradiotherapy stimulated protective reaction of surrounding tissue which took the form of increase in fraction of leukocytes and macrophages with high acid phosphatase level in areas of tumor cell damage.

[Local hyperthermia and hyperglycemia in ORL oncology]. / Lokal'naia gipertermiia i giperglikemiia v LOR-onklologii.

Two-year experience of radiotherapy combined with local hyperthermia, hyperglycemia and chemotherapeutic drugs in patients with tumors of the upper respiratory tract showed advantages of this method. The results were compared with those of the control group of patients on radiotherapy only. Three therapeutic schemes were employed. Hyperthermia was performed in 2 temperature regimens. Of chemotherapeutic drugs platidiam, methotrexate, 5-FU and vinblastine were used.

[Multifield local hyperthermia as a method for heating deeply located neck tissues]. / Mnogopolevaia lokal'naia gipertermiia kak metod nagreva gluboko raspolozhennykh tkanei shei.

Distribution of the thermal field in neck tissues in local SHF-hyperthermia is studied. The two-field method of irradiation permits a uniform heating of more deeply located layers of the tissue due to summation of the radiant energy. So, the contact method of irradiation using "Luch-2" and "Luch-3" sets permits elevating the temperature inside the larynx up to 41-41.5 degrees C and maintaining it under given conditions for 25-30 min, but the heat loading on the skin and subcutaneous fat remains high. When using noncontact irradiators and "Parus" set the deeply located neck tissues are heated to 42-43 degrees C, the temperature of surface layers not exceeding 41-42 degrees C. This temperature rate is possible to be maintained for 25 min; its prolongation induces a sharp rise in the temperature of surface layers. Long-term SHF-hyperthermia of deeply located neck tumours necessitates cooling of the integument surface.

[Radiation therapy with local UHF hyperthermia in the late stages of laryngeal cancer]. / Luchevaia terapiia s lokal'noi SVCh-gipertermiei pri rake gortani v pozdnykh stadiiakh.

Altogether 47 patients with advanced laryngeal and laryngopharyngeal tumors were treated. Twenty-six patients received multimodality therapy including local UHF-hyperthermia and gamma-beam therapy; 21 patients receiving radiotherapy only were entered in the control group. Hyperthermia was induced by the electromagnetic field with the frequency of 2450 and 915 MHz. Parus and Plot units were used. External irradiation was provided. Clinically, complete primary tumor regression was achieved in 20 of 26 patients. A positive effect was absent in 3 cases when metastasis size was 10 X 12 X 8 cm. In the control group, clinically complete tumor regression was noted in 2 patients only. In 4 cases the effect was insignificant, in the rest of 15 cases various degrees of a decrease in tumor and metastasis sizes were revealed.