RESUMO
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors following an investigation into data manipulation (Fig.3A-D and Fig.4A-F) by an Investigation Committee at Kobe Gakuin University. Namely: Fig.3A-D and Fig.4A-F numerical disagreement (numbers removed) was found in some parts between the raw data and the article data, hence the significant difference illustrated in the published article was not obtained.
Assuntos
Orexinas/metabolismo , Nervo Vago/efeitos dos fármacos , Nervo Vago/fisiologia , Animais , Isquemia Encefálica/complicações , Intolerância à Glucose/complicações , Doenças Hipotalâmicas , Hipotálamo/metabolismo , Hipotálamo/fisiologia , Infarto da Artéria Cerebral Média/complicações , Inflamação , Insulina/farmacologia , Interleucina-1beta/farmacologia , Peptídeos e Proteínas de Sinalização Intracelular , Fígado/metabolismo , Masculino , Bulbo/metabolismo , Bulbo/fisiologia , Memória/efeitos dos fármacos , Camundongos , Neurônios/metabolismo , Orexinas/efeitos dos fármacos , Receptor de Insulina/metabolismo , Fator de Necrose Tumoral alfa/metabolismo , Nervo Vago/metabolismoRESUMO
Central post-stroke pain (CPSP), a potential sequela of stroke, is classified as neuropathic pain. Although we recently established a CPSP-like model in mice, the effects of adjuvant analgesics as therapeutic drugs for neuropathic pain in this model are unknown. Hence, the aim of the present study was to assess the usefulness of our model by evaluating the effects of adjuvant analgesics used for treating neuropathic pain in this mouse model of CPSP. Male ddY mice were subjected to 30 min of bilateral carotid artery occlusion (BCAO). The development of hind paw mechanical allodynia was measured after BCAO using the von Frey test. The mechanical allodynia was significantly increased on day 3 after BCAO compared with that during the pre-BCAO assessment. BCAO-induced mechanical allodynia was significantly decreased by intraperitoneal injections of imipramine (a tricyclic antidepressant), mexiletine (an antiarrhythmic), gabapentin (an antiepileptic), or a subcutaneous injection of morphine (an opioid receptor agonist) compared with that following vehicle treatment in BCAO-mice. By contrast, milnacipran (a serotonin and norepinephrine reuptake inhibitor), paroxetine (selective serotonin reuptake inhibitor), carbamazepine (antiepileptic), and indomethacin (nonsteroidal anti-inflammatory drug) did not affect the BCAO-induced mechanical allodynia. Our results show that BCAO in mice may be useful as an animal model of CPSP. In addition, BCAO-induced mechanical allodynia may be suppressed by some adjuvant analgesics used to treat neuropathic pain.