TENS is harmful in primary writing tremor.

OBJECTIVE: It is unclear whether primary writing tremor (PWT) is a tremulous form of dystonia or a tremor per se. Transcutaneous electrical nerve stimulation (TENS) at 50 Hz applied for 2 weeks was reported to improve the writing capabilities of patients with writer's cramp (WC). We explored whether such a beneficial effect can be obtained in patients with a PWT. METHODS: In a cross-over, double-blinded randomized study we tested whether 2-week periods of 5, 25 or 50 Hz TENS applied to wrist flexor muscles, improved the score of the Fahn-Tolosa-Marin scale of nine patients with PWT. Excitability of neurons and of various intracortical circuits in the motor cortex were also tested before and after TENS by using transcranial magnetic stimulation. RESULTS: TENS at 5 and 25 Hz did not have any effect while TENS at 50 Hz worsened the clinical condition and the cortical excitability. CONCLUSIONS: TENS is not a new treatment alternative for PWT. SIGNIFICANCE: The beneficial effect in WC and the harmful one in PWT of TENS stresses that the two disorders are likely different nosological entities.

[Neuropathy with non-alcoholic thiamine deficiency: two cases of bladder disorders]. / Neuropathies par carence en thiamine sans intoxication alcoolique: deux cas de troubles vésicosphinctériens.

INTRODUCTION: Neuropathy with non-alcoholic thiamine deficiency is reported in the literature, but bladder disorders are rarely detailed. CASE REPORTS: We report two cases of bladder disorders in neuropathy with thiamine deficiency. One patient presented with a flaccid bladder and impaired sensation; the postvoid residual volume was raised. The other patient had reduced bladder capacity, with detrusor hyperreflexia and detrusor-sphincter dyssynergia. In both cases, the bladder disorders disappeared with thiamine supplementation. CONCLUSION: Bladder symptoms may be heterogeneous in nonalcoholic neuropathy. The prognosis is good after vitamin supplementation.