RESUMO
Over 100 million Americans suffer from chronic pain (CP), which causes more disability than any other medical condition in the United States at a cost of $560-$635 billion per year (Institute of Medicine, 2011). Opioid analgesics are frequently used to treat CP. However, long term use of opioids can cause brain changes such as opioid-induced hyperalgesia that, over time, increase pain sensation. Also, opioids fail to treat complex psychological factors that worsen pain-related disability, including beliefs about and emotional responses to pain. Cognitive behavioral therapy (CBT) can be efficacious for CP. However, CBT generally does not focus on important factors needed for long-term functional improvement, including attainment of personal goals and the psychological flexibility to choose responses to pain. Acceptance and Commitment Therapy (ACT) has been recognized as an effective, non-pharmacologic treatment for a variety of CP conditions (Gutierrez et al., 2004). However, little is known about the neurologic mechanisms underlying ACT. We conducted an ACT intervention in women (n = 9) with chronic musculoskeletal pain. Functional magnetic resonance imaging (fMRI) data were collected pre- and post-ACT, and changes in functional connectivity (FC) were measured using Network-Based Statistics (NBS). Behavioral outcomes were measured using validated assessments such as the Acceptance and Action Questionnaire (AAQ-II), the Chronic Pain Acceptance Questionnaire (CPAQ), the Center for Epidemiologic Studies Depression Scale (CES-D), and the NIH Toolbox Neuro-QoLTM (Quality of Life in Neurological Disorders) scales. Results suggest that, following the 4-week ACT intervention, participants exhibited reductions in brain activation within and between key networks including self-reflection (default mode, DMN), emotion (salience, SN), and cognitive control (frontal parietal, FPN). These changes in connectivity strength were correlated with changes in behavioral outcomes including decreased depression and pain interference, and increased participation in social roles. This study is one of the first to demonstrate that improved function across the DMN, SN, and FPN may drive the positive outcomes associated with ACT. This study contributes to the emerging evidence supporting the use of neurophysiological indices to characterize treatment effects of alternative and complementary mind-body therapies.
RESUMO
OBJECTIVES: To assess the impact of 5 commonly used patient attribution methods on measured healthcare cost, quality, and utilization metrics within an integrated healthcare delivery system. STUDY DESIGN: Cross-sectional analysis of administrative data of all patients attributed (by any of 5 methods) and/or paneled to a primary care provider (PCP) at Mayo Clinic Rochester (MCR) in 2011. METHODS: We retrospectively applied 5 attribution methods to MCR administrative data from January 1, 2010, to December 31, 2011. MCR is an integrated healthcare delivery system serving primary care and referral populations. The referral practice is geographically colocated but otherwise distinct from 6 primary care practice sites that include pediatric, internal medicine, and family medicine groups. Patients attributed by each method were compared on their concordance with PCP empanelment, quality measures, healthcare utilization, and total costs of care. RESULTS: The 5 methods attributed between 61,813 (42%) and 106,152 (72%) of paneled patients to a PCP at MCR, although not necessarily to the paneled PCP. There was marked variation in care utilization and total costs of care, but not quality measures, among patients attributed by the different methods and between those paneled versus not paneled. Patients with more primary care visits were more likely to be attributed by all methods. CONCLUSIONS: Reliable identification of the physician-patient relationship is necessary for accurate evaluation of healthcare processes, efficiencies, and outcomes. Optimization and standardization of attribution methods are therefore essential as health systems, payers, and policy makers seek to evaluate and improve the value of delivered care.