RESUMO
The effect of combined UVB-UVA treatment in a group of 23 patients with severe atopic eczema was compared to UVB therapy alone in 33 patients. Mean age and number of treatments were approximately the same in the two groups. With UVB-UVA treatment, 48% achieved complete remission and in another 48% good improvements were obtained as compared to 27 and 58%, respectively, in the group treated with UVB alone. A few failures were recorded in the UVB group. Some possible explanations for the better effect of the combined UVB-UVA treatment are given.
Assuntos
Dermatite Atópica/radioterapia , Terapia Ultravioleta , Adolescente , Adulto , Bactérias/efeitos da radiação , Criança , Feminino , Humanos , Masculino , Raios UltravioletaRESUMO
Phytophotodermatitis of Heracleum laciniatum is quite common in Tromsø during the summer months. The clinical picture varies from mild to severe erythematous reactions with or without vesicles or bullae on the exposed parts of the body. Phototoxic reactions of Heracleum laciniatum are reported. The influences on phototoxic reactions by bergapten (5-methoxypsoralen) and UV-A by treating the skin with a membrane labilizing agent, dimethyl sulphoxide (DMSO), and a membrane stabilizing agent, the steroid desoximethasone, are evaluated.
Assuntos
Desoximetasona/uso terapêutico , Dexametasona/análogos & derivados , Dimetil Sulfóxido/uso terapêutico , Transtornos de Fotossensibilidade/etiologia , Plantas Tóxicas , 5-Metoxipsoraleno , Furocumarinas/toxicidade , Humanos , Metoxaleno , Transtornos de Fotossensibilidade/prevenção & controle , Extratos Vegetais/toxicidade , Pele/efeitos dos fármacos , Pele/efeitos da radiação , Raios UltravioletaRESUMO
Experimental phytophotodermatitis was produced using homogenates from different parts of Heracleum laciniatum and long-wave ultraviolet light. The homogenates of leaves and flowers produced strong phototoxic reactions, fruit slightly less. Stems were either non-phototoxic or only slightly phototoxic. The roots of young plants did not evoke photosensitivity reactions, whereas the roots of older plants were strongly phototoxic; even roots collected from the frozen ground in December elicited strong reactions. Abdominal and midback skin were more photosensitive than skin of the lateral aspects of the underarms and legs.
Assuntos
Transtornos de Fotossensibilidade/etiologia , Extratos Vegetais/toxicidade , Candida albicans/metabolismo , Candida albicans/efeitos da radiação , Humanos , Técnicas In Vitro , Extratos Vegetais/metabolismo , Extratos Vegetais/efeitos da radiação , Plantas/metabolismo , Estações do Ano , Testes CutâneosRESUMO
Irritant skin reactions were produced within 1 h after application of the exocarp of sweet oranges or alcoholic extracts therefrom. Such reactions faded within 48 h. The exocarp, or extracts thereof, induced phototoxic reactions which were strongest at 72 h after exposure. The phototoxic reactions were only induced in natural blondes and only with some oranges. The in vivo phototoxic reactions were confirmed in vitro, causing a slight but clear photo-inhibition of Candida albicans. Only some oranges inhibited growth.
Assuntos
Queilite/etiologia , Citrus/toxicidade , Transtornos de Fotossensibilidade/etiologia , Humanos , Extratos Vegetais/toxicidadeRESUMO
A case of chronic urticaria and vitiligo, associated with thyroiditis is described. Significantly elevated thyromicrosomal antibodies were found. Autoimmune reaction is a possible cause of the patient's thyroid disease, vitiligo and chronic urticaria. Following PUVA treatment with a total dose of 300 J/cm2 the patient's urticaria subsided in all irradiated areas, only to relapse 2 weeks later. Subsequently courses of PUVA gave periods of remission. The treatment also induced repigmentation in the vitiliginous spots. The results indicate a local PUVA effect upon mediators or mediator-containing cells.