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Photodiagnosis Photodyn Ther ; 44: 103820, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-37788795

RESUMO

INTRODUCTION: Non-melanoma skin cancer within previously irradiated areas presents a common challenge, requiring innovative therapies. Complex scenarios, like XRT-induced basal cell carcinoma (BCC) or Gorlin's syndrome, often involve multiple synchronous tumor lesions where photodynamic therapy (PDT) offers a viable therapeutic alternative. CLINICAL CASE: We present the case of a 49-year-old male with a history of XRT for brain tumors. The patient was undergoing treatment for recurrent basal cell carcinomas (BCCs) in the right temporal irradiated area, unresponsive to conventional treatments. In the latest evaluation, the patient presented a nodular tumor and several peripheral superficial foci. Photodynamic therapy (PDT) was administered using methyl aminolevulinate 160 mg/g in cream (Metvix®) in two sessions spaced 7 days apart before surgery. The photosensitizer was applied 3 h before initiating PDT, and red light exposure was performed with the Aktilite© lamp (wavelength 630 nm, 100 mm distance, voltage 100 to 240 V, frequency 50 Hz, power 180 W) for 7 min. CONCLUSIóN: PDT with methyl aminolevulinate demonstrated efficacy as a neoadjuvant treatment in a case of multiple XRT-induced BCCs before surgery. PDT emerges as a valuable therapeutic alternative for multiple BCCs, particularly in non-responsive cases.


Assuntos
Síndrome do Nevo Basocelular , Carcinoma Basocelular , Fotoquimioterapia , Neoplasias Cutâneas , Masculino , Humanos , Pessoa de Meia-Idade , Fármacos Fotossensibilizantes/uso terapêutico , Terapia Neoadjuvante , Neoplasias Cutâneas/patologia , Fotoquimioterapia/métodos , Carcinoma Basocelular/tratamento farmacológico , Carcinoma Basocelular/radioterapia , Carcinoma Basocelular/patologia , Ácido Aminolevulínico/uso terapêutico , Síndrome do Nevo Basocelular/tratamento farmacológico , Resultado do Tratamento
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