RESUMO
The presence of several active foci of infection of different etiology is an indication for complex (combined) immunization against these diseases. The scheme of complex (combined) immunization against plague, cholera and yellow fever has been experimentally substantiated and successfully tested on volunteers.
Assuntos
Vacinas contra Cólera/imunologia , Vacina contra a Peste/imunologia , Quarentena , Vacinas Virais/imunologia , Vírus da Febre Amarela/imunologia , Adolescente , Adulto , Animais , Cólera/imunologia , Cólera/prevenção & controle , Vacinas contra Cólera/efeitos adversos , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Cobaias , Humanos , Camundongos , Camundongos Endogâmicos BALB C , Papio , Peste/imunologia , Peste/prevenção & controle , Vacina contra a Peste/efeitos adversos , Coelhos , Ratos , Vacinas Combinadas/efeitos adversos , Vacinas Combinadas/imunologia , Vacinas Virais/efeitos adversos , Febre Amarela/imunologia , Febre Amarela/prevenção & controleRESUMO
The article substantiates epidemiological expediency of complex (associated) immunization of servicemen and population against typhoid, typhus and plague in polyetiological zones of these infections, and also in cases of simultaneous proliferation of these diseases. For simultaneous preventive vaccination against these infections a complex immunization scheme was experimentally substantiated and clinically approved. It is based on national commercial vaccines and ensures a simultaneous administration of 2-3 vaccine preparations by hypodermic syringe or jet injection. Typhoid and typhus vaccines are injected under one shoulder-blade, and plague vaccine is injected under another shoulder-blade. This complex vaccine is harmless, moderately reactogenic, develops expressing immunity which have the same protective features as monovaccines alone. This scheme is recommended for use in anti-epidemic practice.
Assuntos
Imunização , Vacina contra a Peste/imunologia , Peste/prevenção & controle , Rickettsia prowazekii/imunologia , Vacinas Antirrickéttsia/imunologia , Febre Tifoide/prevenção & controle , Vacinas Tíficas-Paratíficas/imunologia , Tifo Epidêmico Transmitido por Piolhos/prevenção & controle , Adolescente , Adulto , Animais , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Cobaias , Humanos , Camundongos , Militares , Vacina contra a Peste/efeitos adversos , Vacinas Antirrickéttsia/efeitos adversos , Federação Russa , Vacinas Tíficas-Paratíficas/efeitos adversos , Vacinas Atenuadas/efeitos adversos , Vacinas Atenuadas/imunologia , Vacinas Combinadas/efeitos adversos , Vacinas Combinadas/imunologia , Vacinas Sintéticas/efeitos adversos , Vacinas Sintéticas/imunologiaRESUMO
A safe, moderately reactogenic and immunologically effective scheme of complex (combined) immunization against meningitis A, diphtheria, typhoid fever, viral hepatitis A and influenza has been developed as the result of experimental and clinico-immunological studies. Depending on the epidemiological situation, the newly developed scheme can be used in two variants. According to the first variant of this scheme, the following preparations are injected subcutaneously into three different sites: a mixture of group A meningococcal vaccine and diphtheria toxoid, typhoid vaccine and influenza vaccine. The second variant of the scheme differs from its first variant in using intramuscular injection of normal human immunoglobulin instead of injection of influenza vaccine. Moreover, in practical realization these variants may be altered by excluding vaccines, unnecessary under present conditions. The newly developed scheme of vaccinal prophylaxis is recommended for practical use.