RESUMO
Local cerebral blood flow (LCBF) was reduced following plaferon administration in rabbits due to impairment of the vasodilator responses of cerebral vessels or their transformation into vasoconstrictor responses, the effect being added to that of vasoconstrictor responses to vasoactive neuropeptides contained in plaferon.
Assuntos
Hipóxia Encefálica/tratamento farmacológico , Neuropeptídeos/uso terapêutico , Vasodilatadores/uso terapêutico , Animais , Isquemia Encefálica/tratamento farmacológico , Isquemia Encefálica/fisiopatologia , Circulação Cerebrovascular/efeitos dos fármacos , Avaliação Pré-Clínica de Medicamentos , Hipóxia Encefálica/fisiopatologia , Neuropeptídeos/farmacologia , Coelhos , Fatores de Tempo , Vasodilatadores/farmacologiaRESUMO
Non-invasion model for photochemically induced brain infarction was used to study the effect of a the new anti-ischemic drug LB ("Plaferon") in albino rats. Intensity of a local blood flow was measured so as oxygen tension in brain cortex. Square and volume of the disturbed nervous tissue region, capillary length and density of distribution of different caliber vessels were detected by means of light microscopy in serial sections of brain cortex. Preliminary introduction of LB was found to prevent formation of thrombotic infarction (the volume of cortical zone damaged is 85% lower as compared to the control). Anti-ischemic effect of LB implicates in vasodilatory action on cerebral vessels and also breaking pathogenic chain of ischemia development.
Assuntos
Córtex Cerebral/efeitos dos fármacos , Infarto Cerebral/prevenção & controle , Embolia e Trombose Intracraniana/prevenção & controle , Neuropeptídeos/uso terapêutico , Vasodilatadores/uso terapêutico , Animais , Córtex Cerebral/patologia , Infarto Cerebral/etiologia , Infarto Cerebral/patologia , Modelos Animais de Doenças , Avaliação Pré-Clínica de Medicamentos , Embolia e Trombose Intracraniana/etiologia , Embolia e Trombose Intracraniana/patologia , Fotoquímica , Fármacos Fotossensibilizantes , Ratos , Rosa Bengala , Fatores de TempoRESUMO
The effect of plaferon on the local cerebral blood flow and brain tissue oxygen tension during transient incomplete ischemia and following recirculation, was studied. The difference revealed between experimental and control data is, probably, due to vasodilatory action of the vasoactive neuropeptides and the effect on the systems of phosphorylation.
Assuntos
Hipóxia Encefálica/tratamento farmacológico , Ataque Isquêmico Transitório/tratamento farmacológico , Neuropeptídeos/uso terapêutico , Vasodilatadores/uso terapêutico , Animais , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Encéfalo/ultraestrutura , Circulação Cerebrovascular/efeitos dos fármacos , Avaliação Pré-Clínica de Medicamentos , Hipóxia Encefálica/complicações , Hipóxia Encefálica/patologia , Hipóxia Encefálica/fisiopatologia , Ataque Isquêmico Transitório/etiologia , Ataque Isquêmico Transitório/patologia , Ataque Isquêmico Transitório/fisiopatologia , Neuropeptídeos/farmacologia , Consumo de Oxigênio/efeitos dos fármacos , Pressão Parcial , Coelhos , Vasodilatadores/farmacologiaRESUMO
In wakefulness and paradoxical sleep, fast waves prevailed in the PO2 oscillations in the posterior hypothalamus whereas in slow wave sleep fast oscillations of PO2 prevailed in the anterior hypothalamus and preoptic area. These shifts of the PO2 during wakefulness and PS seem to reflect an enhancement of the functional activity of the posterior hypothalamus. During slow wave sleep, the functional activity must be enhanced in the anterior hypothalamus and preoptic area, while in the posterior hypothalamus it is suppressed.