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Clin Diagn Lab Immunol ; 7(6): 899-903, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11063495

RESUMO

Vaccination to protect against human infectious diseases may be enhanced by using adjuvants that can selectively stimulate immunoregulatory responses. In a murine model, a novel nanoparticulate adjuvant composed of calcium phosphate (CAP) was compared with the commonly used aluminum (alum) adjuvants for its ability to induce immunity to herpes simplex virus type 2 (HSV-2) and Epstein-Barr virus (EBV) infections. Results indicated that CAP was more potent as an adjuvant than alum, elicited little or no inflammation at the site of administration, induced high titers of immunoglobulin G2a (IgG2a) antibody and neutralizing antibody, and facilitated a high percentage of protection against HSV-2 infection. Additional benefits of CAP include (i) an insignificant IgE response, which is an important advantage over injection of alum compounds, and (ii) the fact that CAP is a natural constituent of the human body. Thus, CAP is very well tolerated and absorbed. These studies were performed with animal models. By virtue of the potency of this CAP adjuvant and the relative absence of side effects, we believe that this new CAP formulation has great potential for use as an adjuvant in humans.


Assuntos
Adjuvantes Imunológicos/administração & dosagem , Fosfatos de Cálcio/administração & dosagem , Adjuvantes Imunológicos/toxicidade , Compostos de Alúmen/administração & dosagem , Animais , Fosfatos de Cálcio/toxicidade , Infecções por Vírus Epstein-Barr/imunologia , Infecções por Vírus Epstein-Barr/prevenção & controle , Feminino , Cobaias , Herpes Genital/imunologia , Herpes Genital/prevenção & controle , Herpesvirus Humano 2/imunologia , Herpesvirus Humano 4/imunologia , Humanos , Imunoglobulina E/biossíntese , Imunoglobulina G/biossíntese , Inflamação/etiologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Testes de Neutralização , Vacinas Virais/administração & dosagem
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