1.
J Antibiot (Tokyo)
; 74(4): 266-268, 2021 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-33446930
RESUMO
A fungal metabolite, diatretol, has shown to be a promising antimalarial agent. Diatretol displayed potent in vitro antiparasitic activity against the Plasmodium falciparum K1 strain, with an IC50 value of 378 ng ml-1, as well as in vivo efficacy in a Plasmodium berghei-infected mice model, with ca. 50% inhibition at 30 mg/kg (p.o.).