Increase adapalene delivery using chemical and herbal enhancers.

BACKGROUND: Acne is one of the skin diseases that include abnormalities in the production of sebum, changes in the microbial flora, abnormal keratinization, and inflammation. Adapalene is a good choice in the treatment of acne with fewer side effects and high effectiveness. However, the absorption of adapalene through human skin is low. We investigated the effect of several enhancers on the skin absorption of adapalene. METHODS: For the preparation of a topical formulation, this drug needs proper skin absorption. Therefore, to increase the effect of chemical absorption of the Adapalene skin permeability, it should first be put on the skin in a touch of some absorption like Eucalyptus, Urea, Clove oil, propylene glycol, and oleic acid for 1 and 2 hours and was then examined for the passing of the drug on the treated skin and for the effect of absorptions by calculating of the permeability parameters using DSC and FT-IR techniques. RESULT AND CONCLUSION: The results show that the enhancers used increased the permeability of the drug adapalene to water. Several mechanisms including lipid liquefaction, degradation of the fat structure, as well as irreversible denaturation of intracellular creatine caused by Eucalyptus, urea clove oil, PG, and oleic acid are the main mechanisms of drug penetration. Based on the results, it was found that among the enhancers studied, eucalyptus and urea had the highest and the lowest absorption effect in 2- and 1-hour pre-contact, respectively.

Preparation and evaluation of a free surfactant herbal shampoo with Acanthophyllum Squarrosum Saponins.

BACKGROUND: Shampoos remove fat and pus from the skin and hair. The most critical part of these products is their cleansing properties; therefore, the amount of shampoo cleanser plays an essential role in consumer acceptance. AIM: The production of herbal shampoos from root saponins in Hawthorn can lead to the removal of these substances from shampoos. Squarrosum is one of the 23 Acanthophyllum species that is native to Iran. The root of this plant has been used traditionally as a consumption detergent due to the presence of saponins. METHOD: To make the shampoo, saponins were extracted through several steps by a solvent after Acanthophyllum squarrosum scientific specimens had been prepared and identified The shampoo's fatigue strength was tested using the Ross-Miles method, and its cleansing power was assessed using Thompson's test. RESULTS: The optimum formula with 15% total saponins content was evaluated. CONCLUSION: This liquid shampoo has an excellent cleansing effect, is suitable for regular hair; has pseudoplastic rheology; and has acceptable pH, surface tension, and organoleptic stability characteristics.