RESUMO
Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A-D (1-4), from the acetone extract of the leaves of Macaranga trichocarpa. Re-examination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and found to be mostly moderate antibacterial agents, with the lowest MIC value of 26.5 µM achieved by the flavanone macatrichocarpin A (1) against Bacillus subtilis.
Assuntos
Antibacterianos/química , Chalconas/química , Euphorbiaceae/química , Flavanonas/química , Avaliação Pré-Clínica de Medicamentos , Flavonas/química , Flavonoides/química , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Extratos Vegetais/química , Folhas de Planta/química , Raios UltravioletaRESUMO
Two geranylated and methylated flavonol derivatives, macarhizinoidins A (1) and B (2), along with a known phenolic compound methyl 4-isoprenyloxycinnamate (3), have been isolated from the methanol extract of the leaves M. rhizinoides. The structures of these compounds were identified based on their spectroscopic data. On cytotoxic evaluation against murine leukemia P-388 cells, compounds 1-2 showed IC50 values of 11.4 and 13.9 microM, respectively, while compound 3 was inactive.
Assuntos
Euphorbiaceae/química , Flavonóis/isolamento & purificação , Animais , Flavonóis/química , Flavonóis/farmacologia , Leucemia P388/tratamento farmacológico , Leucemia P388/patologia , Camundongos , Extratos Vegetais/análiseRESUMO
A new oligostilbenoid, diptoindonesin C, has been isolated from the tree bark of Shorea pinanga Scheff., along with the two known oligostilbenoids gnetin H and hopeaphenol, and a known coumarin scopoletin. The new oligostilbenoid was moderately active against brine shrimps Artemia salina.
Assuntos
Dipterocarpaceae/química , Casca de Planta/química , Extratos Vegetais/isolamento & purificação , Estilbenos/isolamento & purificação , Estrutura Molecular , Fenóis , Estilbenos/análise , Estilbenos/químicaRESUMO
Two new isoprenylated flavones, artoindonesianins U (1) and V (2), have been isolated from the heartwood of Artocarpus champeden together with three known isoprenylated flavonoids, 5'-hydroxycudraflavone A, cyclocommunin and artonin B. The structures of the new flavones were elucidated on the basis of spectroscopic evidence. Both compounds 1 and 2 showed strong cytotoxic activity against P-388 cell lines.