Content of trace elements in the lymph and blood during pyrogenal-induced fever and complete freund's adjuvant-induced low-grade fever.

Experiments on rats showed that complete Freund's adjuvant-induced low-grade fever and pyrogenal-induced fever are accompanied by an increase in the content of Mn, Cu, Zn, and Se in the thoracic duct lymph. Our results indicate that the lymphatic system supplies trace elements to the circulation, which compensates for a deficiency in trace elements and maintains their systemic circulation. The decrease in the content of some trace elements in the blood during fever is probably associated with their excessive consumption (e.g., to maintain the antioxidant defense system). During experimental low-grade fever and pyrogenal-induced fever, the lymphatic system serves as the reservoir for trace elements and plays a role in the regulation of trace element balance in biological fluids.

[Effect of kontrikal on the kinin system of the lymph and blood in anaphylactic shock]. / Vliianie kontrikala na kininovuiu sistemu limfy i krovi pri anafilakticheskom shoke.

A study was made of the effect of contrykal, a nonspecific inhibitor of the trypsin-plasmin-kallikrein system on the time course of kininogens and free kinins in the lymph of the thoracic duct and blood. Experiments were performed on 42 guinea-pigs with anaphylactic shock. It was demonstrated that anaphylactic shock was accompanied by the activation of the blood and lymph kinin system, manifesting in a decrease in the bradykininogen level and a rise in the content of free kinins in both body fluids. Pretreatment with contrykal did not avert the development of anaphylactic shock but significantly reduced the pronounced manifestations of the clinical picture and exerted an inhibitory action on the activation of the kallikrein-kinin system of the blood and lymph.