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OBJECTIVE@#To observe the clinical efficacy of early acupuncture for vascular dementia (VD) after cerebral infarction, and explore its possible mechanism.@*METHODS@#A total of 120 patients with VD after cerebral infarction were randomized into an acupuncture combined with medication group (60 cases, 1 case dropped off) and a western medication group (60 cases, 1 case dropped off). In the western medication group, oxiracetam capsules were given orally, 2 capsules each time, 3 times a day. On the basis of the treatment as the western medication group, @*RESULTS@#The total effective rate was 89.8% (53/59) in the acupuncture combined with medication group, which was superior to 76.3% (45/59) in the western medication group (@*CONCLUSION@#Early acupuncture could improve cognitive function and activities of daily living in patients with VD after cerebral infarction, its mechanism may be related to improving the blood flow velocity of MCA, promoting blood circulation, and improving cerebral perfusion.
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Humanos , Atividades Cotidianas , Pontos de Acupuntura , Terapia por Acupuntura , Infarto Cerebral/terapia , Cognição , Demência Vascular/terapia , Resultado do TratamentoRESUMO
OBJECTIVE@#To observe the therapeutic effect of electroacupuncture on lumbar disc herniation (LDH) with different multifidus fatty infiltration rates.@*METHODS@#A total of 108 eligible LDH patients received MRI test before treatment and the multifidus fatty infiltration rate (FI) was measured. According to theresults, they were divided to group A (FI20%), 36 cases in each one. EA was provided in all of the groups. The selected acupoints were Jiaji (EX-B 2) from L@*RESULTS@#Compared with before treatment, ODI score was reduced (@*CONCLUSION@#Electroacupuncture relieves pain and improves physical and psychological health of LDH patients. Multifidus fatty infiltration rate is probably one of the factors to influence the therapeutic effect of electroacupuncture.
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Humanos , Pontos de Acupuntura , Eletroacupuntura , Degeneração do Disco Intervertebral , Deslocamento do Disco Intervertebral/terapia , Vértebras Lombares , Músculos ParaespinaisRESUMO
Liver fibrosis has a complex pathogenesis, and at present, the research mainly focuses on hepatic stellate cells (HSC). Many stimulating factors and regulatory pathways have been found to promote the activation of HSC. This article reviews the recent research findings on several major cytokines and peroxisome proliferator-activated receptor γ and research hotspots in recent years, including the association of microRNAs, long non-coding RNA, and exosomes with HSC activation. This article also introduces potential targets for the treatment of liver fibrosis and new markers for noninvasive diagnosis of liver diseases and proposes that chemical drugs or traditional Chinese medicine compounds which act on the targets of HSC activation can be formulated, in order to make a breakthrough in the therapeutics of liver fibrosis.
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Liver fibrosis has a complex pathogenesis, and at present, the research mainly focuses on hepatic stellate cells (HSC). Many stimulating factors and regulatory pathways have been found to promote the activation of HSC. This article reviews the recent research findings on several major cytokines and peroxisome proliferator-activated receptor γ and research hotspots in recent years, including the association of microRNAs, long non-coding RNA, and exosomes with HSC activation. This article also introduces potential targets for the treatment of liver fibrosis and new markers for noninvasive diagnosis of liver diseases and proposes that chemical drugs or traditional Chinese medicine compounds which act on the targets of HSC activation can be formulated, in order to make a breakthrough in the therapeutics of liver fibrosis.
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<p><b>OBJECTIVE</b>To investigate the effect of Ganfukang (GFK) on connective tissue growth factor (CTGF) and focal adhesion kinase (FAK)/protein kinase B (PKB or Akt) signal pathway in a hepatic fibrosis rat model and to explore the underlying therapeutic molecular mechanisms of GFK.</p><p><b>METHODS</b>Fifty SD rats were randomly divided into five groups as follows: the control group, the model group (repeated subcutaneous injection of CCl4), and the three GFK treatment groups (31.25, 312.5, and 3125 mg/kg, intragastric administration). Reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting, and immunohistochemistry were used to examine the expression of CTGF, integrin α5, integrin β1, FAK/Akt signal pathway, cyclinD1, and collagen in the different-treated rats.</p><p><b>RESULTS</b>GFK attenuated the up-regulation of CTGF, integrin α5, and integrin β1 in hepatic fibrosis rats and suppressed both the phosphorylation of FAK and the phosphorylation of Akt simultaneously (P<0.01). At the same time, the expression of cyclinD1, collagen I, and collagen III was decreased by GFK significantly (P<0.01).</p><p><b>CONCLUSIONS</b>CTGF and FAK/Akt signal pathway were activated in the CCl4-induced hepatic fibrosis rats, which contribute to increased expression of cyclinD1 and collagen genes. The mechanisms of the anti-fibrosis activity of GFK may be due to its effects against CTGF and FAk/Akt signal pathway.</p>
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Animais , Feminino , Masculino , Colágeno , Genética , Metabolismo , Fator de Crescimento do Tecido Conjuntivo , Genética , Metabolismo , Ciclina D1 , Genética , Metabolismo , Medicamentos de Ervas Chinesas , Farmacologia , Usos Terapêuticos , Proteína-Tirosina Quinases de Adesão Focal , Metabolismo , Regulação da Expressão Gênica , Integrina alfa5 , Genética , Metabolismo , Integrina beta1 , Genética , Metabolismo , Fígado , Patologia , Cirrose Hepática , Tratamento Farmacológico , Genética , Patologia , Fosforilação , Proteínas Proto-Oncogênicas c-akt , Metabolismo , Ratos Sprague-Dawley , Transdução de SinaisRESUMO
ObjectiveTo observe the clinical efficacy of acupuncture-moxibustion in treating tinnitus.MethodNinety-eight patients with tinnitus were divided into a warm-needling group (n=32), an acupuncture group (n=34), and a medication group (n=32), to observe thetherapeuticefficacies.ResultThe total effective rate was 83.3% in the warm-needling group, versus 78.8% in the acupuncture group and 60.0% in the medication group.ConclusionWarm needling and acupuncture plus TDP are both superior to the medication treatment in comparing the therapeutic efficacy.