RESUMO
Eighteen dammarane-type triterpenes were obtained from the whole plant of Cleome africana by means of cytotoxic bioassay-directed fractionation. Twelve of them were novel compounds whose structures were elucidated by various spectroscopic methods.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Sobrevivência Celular/efeitos dos fármacos , Plantas Medicinais , Triterpenos/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/toxicidade , Região do Caribe , Leucemia P388 , Medicina Tradicional , Camundongos , Estrutura Molecular , Triterpenos/química , Triterpenos/toxicidade , Células Tumorais CultivadasRESUMO
A 19-year-old female was referred to our hospital for azotemia and anemia. She had been taking a health food for atopic dermatitis for about three years. Urinalysis showed proteinuria, glycosuria and microscopic hematuria. Generalized aminoaciduria was observed. Moreover, severe anemia, azotemia, hypokalemia and hypophosphatemia were also observed. Renal biopsy specimen disclosed hypocellular interstitial fibrosis and degeneration of the proximal tubular epithelial cells. No remarkable changes were observed in the glomeruli. Aristolochic acid was detected in the health food. From these findings, she was diagnosed as having Chinese herbs nephropathy (CHN). Although consumption of the food intake was stopped, her renal function deteriorated rapidly. Previously, we reported that certain kinds of Chinese herbal drugs contain aristolochic acid and that the drugs should be prohibited if aristolochic acid is identified. However, we experienced a patient of CHN arising from traditional remedy, which was not proved to be safe. It should be awared that health foods may contain aristolochic acid.
Assuntos
Ácidos Aristolóquicos , Medicamentos de Ervas Chinesas/efeitos adversos , Nefropatias/induzido quimicamente , Rim/fisiopatologia , Fenantrenos/efeitos adversos , Adulto , Medicamentos de Ervas Chinesas/química , Feminino , Humanos , Nefropatias/fisiopatologia , Fenantrenos/isolamento & purificaçãoRESUMO
We reported a case of interstitial pneumonia immediately after hepatic arterial infusion of Lipiodol anticancer drug emulsion for hepatocellular carcinoma. The reason was considered that Lipiodol-anticancer drug emulsion ran through an A-V shunt to alveolar septum resulting in alveolitis.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Carcinoma Hepatocelular/terapia , Óleo Iodado/efeitos adversos , Neoplasias Hepáticas/terapia , Fibrose Pulmonar/induzido quimicamente , Terapia Combinada , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Hepatic arterial embolization was performed on VX2 liver tumor of rabbit with subsequent induction heating to the tumor. Prior to the heating, iron particle suspension was injected into tumor tissue as a target of induction heating (500 KHZ, 9 KW). The temperatures of the tumor and liver parenchyma were measured with fluoroptic thermometer. Elevation of the tumor temperature during initial heating for 6 minutes were well correlated to the dose of iron particles injected; 1.4 degrees C with 1 g, 3.0 degrees C with 2 g, and 4.9 degrees C with 3 g. The temperature of liver parenchyma were below 39 degrees C even with 3 g injection.