The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients.

BACKGROUND: Magnesium (Mg) supplementation may help control glycemic response among type 2 diabetes (T2D) patients. OBJECTIVE: This study means to determine whether Mg supplementation improves glycemic control indicators in patients with T2D. METHODS: After one week of the dietary stabilization phase, 42 T2D patients were stratified according to sex, age, fasting blood sugar (FBS) and Mg levels and then randomly allocated into two groups. The intervention group was on 250 mg/day of elemental Mg for three months while the control group did not receive any type of supplements throughout the intervention period. RESULTS: The daily administration of 250 mg of elemental Mg indicated a significant improvement in HbA1C (8.32 to 7.96%, p < 0.001), insulin levels (IL) (15.56 to 12.18 µIU/mL, p < 0.001), C-peptide (2.28 to 1.90 ng/mL, p = 0.001), HOMA.IR (6.16 to 4.44, p < 0.001) and HOMA.ß% (59.99 to 52.37, p = 0.036) of the intervention group when compared with the control group after three months of intervention. CONCLUSION: The results of this study revealed that oral Mg supplementation reduces insulin resistance and improves the glycemic control indicators among T2D patients. TRIAL REGISTRATION: current controlled trials PHRC/HC/32/15. Registered 5 October 2015.

Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial).

BACKGROUND: Water-soluble dietary fibers intake may help control blood glucose and body weight. OBJECTIVE: The objective of the study was to determine whether soluble fiber supplementation from psyllium improves glycemic control indicators and body weight in type 2 diabetic patients. METHOD: Forty type 2 diabetes patients, non-smoker, aged >35 years were stratified to different strata according to sex, age, body mass index (BMI) and fasting blood sugar level (FBS) and randomly assigned into two groups; The intervention group which consists of 20 participants was on soluble fiber (10.5 g daily), and the control group which consist of 20 participants continued on their regular diet for eight weeks duration. RESULTS: After 8 weeks of intervention, soluble fiber supplementation showed significant reduction in the intervention group in BMI (p < 0.001) when compared with the control group. Moreover, water soluble fiber supplementation proven to improve FBS (163 to 119 mg/dl), HbA1c (8.5 to 7.5 %), insulin level (27.9 to 19.7 µIU/mL), C-peptide (5.8 to 3.8 ng/ml), HOMA.IR (11.3 to 5.8) and HOMA-ß % (103 to 141 %). CONCLUSION: The reduction in glycemic response was enhanced by combining soluble fiber to the normal diet. Consumption of foods containing moderate amounts of these fibers may improve glucose metabolism and lipid profile in type 2 diabetes patients. TRIAL REGISTRATION: Current Controlled Trials PHRC/HC/28/15 .