[Synthesis and immunomodulating activity of new diglycopeptides of of glycyrrhizinic acid and it's 30-methyl ester]. / Sintez i immunomoduliruiushchaia aktivnost' novykh diglikopeptidov glitsirrizinovoi kisloty i ee 30-metilovogo éfira.

New amino acid derivatives of glycyrrhizic acid and its methyl ester were selectively synthesized using active N-succinimide esters. The compounds with residues of glycine ethyl ester and alanine methyl and butyl esters increased the level of agglutinins and hemolysins in blood serum of mice two- to threefold in comparison with the control upon parenteral administration at a dose of 2 mg/kg for 14 days. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 2; see also http://www.maik.ru.

[Synthesis and immunostimulating activity of cysteine-containing glycopeptide derivatives of glycyrrhizic acid]. / Sintez i immunostimuliruiushchaia aktivnost' tsisteinsoderzhashchikh glikopeptidnykh proizvodnykh glitsirrizinovoi kisloty.

New cysteine-containing derivatives of glycyrrhizic acid were synthesized by its coupling with Cys(Bzl) esters or the Cys(Bzl)-Val-OBu(t) dipeptide by the active ester method (DCC/HOSu) or by Woodward's reagent K. The derivatives with Cys(Bzl) and Cys(Bzl)-Val residues attached to the carbohydrate part of the molecule stimulated the primary immune response and the reaction of delayed-type hypersensitivity in mice at a dose of 2 mg/kg. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 1; see also http://www.maik.ru.

[A toxicological study of a phytopreparation made from an extract of alfalfa (Medicago sativa)]. / Toksikologicheskoe izuchenie fitopreparata iz ékstrakta liutserny posevnoi.

A phytopreparation from lucerne (Medicago sativa) was studied with respect to the acute and chronic toxicity and the action upon the cellular genetic mechanism. It was found that the preparation belongs to the group of practically nontoxic properties.

[The specific activity of new drug forms of dibunol]. / Spetsificheskaia aktivnost' novykh lekarstvennykh form dibunola.

The specific activity of new drug forms (tablets, suppositories, ointments) of dubinal was studies on models of ischemic damage to the heart, toxic hepatitis, aseptic inflammation, damage to the skin and mucosa of the large intestine. It was found that the drug forms under study possessed a cardioprotective, hepatoprotective, anti-inflammatory, and wound-healing effect. This may serve as a prerequisite to their further clinical study.

[The immunotropic activity of erakond]. / Immunotropnaia aktivnost' érakonda.

The effect of eracond on some parameters of immunity and allergic reactions was studied in experiments on mice and guinea pigs. The drug was found to possess an immunomodulating effect.

[The hepatoprotective and cholagogic action of glycyrrhizic acid derivatives]. / Izuchenie gepatoprotektornogo i zhelchegonnogo deistviia proizvodnykh glitsirrizinovoi kisloty.

The experiments on rats with toxic hepatic damage induced by tetrachloromethane have shown that the derivatives of glycyrrhizinic acid (5NGA) promote a decrease in the rate of lipid peroxide oxygenation in the hepatic tissue homogenate and the blood serum, in the inhibition of organospecific enzyme activity (BHMT, ALT, AST) and increase in choleresis. The data obtained testify to the hepatoprotective activity of the derivatives of glycyrrhizinic acid.

[Transformation of glycyrrhizic acid. Synthesis of glycopeptides of glycyrrhizic acid monomethyl ether, having anti-inflammatory and immunostimulating action]. / Transformatsii glitsirrizinovoi kisloty. Sintez glikopeptidov monometilovogo éfira glitsirrizinovoi kisloty, proiavlliaiushchikh protivosvospatitel'noe i immunostimuliruiushchee deistvie.

Three triterpene glycopeptides, glycyrrhizic acid monomethly ester derivatives containing peptide fragment of N-acetylmuramoyldipeptide and its analogues, are synthesized. They possess high prednizolone-like antiinflammatory activity and display pronounced stimulative effect on humoral factors of immunity.

[Effectiveness of nonsteroidal antiphlogistics in experimental diabetes mellitus]. / Effektivnost' nekotorykh nesteroidnykh antiflogistikov pri éksperimental'nom sakharnom diabete.

In experiments on rats with alloxan diabetes efficacy of amidopyrine, acetylsalicylic acid, methyluracil, butadione and brufen in experimental inflammation was shown. The antiinflammatory drugs under study were found to have various effects on insulin and glucose blood levels in intact rats and those with diabetes. The increase in glucose content under the influence of methyluracil is presumably connected with the elevation of somatotrophic hormone blood level. Acetylsalicylic acid and butadione reduce the content of somatotrophic hormone. Methyluracil potentiates antiexudative effects of acetylsalicylic acid and amidopyrine.

[Anti-inflammatory activity of glycyrrhizic acid derivatives]. / Izuchenie protivovospalitel'noi aktivnosti proizvokdnykh glitsirrizinovoi kisloty.

The derivatives of glycyrrhizin acid--dihydrazidohydrazose of glycyrrhizin acid (DHGA), DHGA plus benzaldehyde, DHGA plus 5-nitrofurfurol, DHGA plus furfurol, glycyrrhizin acid, methylmethioninsulfonium-glycyrrhizinate, sodium salt of 18-glycyrrhetic acid, and potassium salt of glycyrrhizin acid--show a pronounced anti-inflammatory action, inhibit the development of histamine-, serotonin-, bradykinin-, and formalin-induced edemas, barrier function of an inflammatory focus, lower vascular permeability, the granulemic sac weight and exudate amount. The anti-inflammatory action of the compounds remains unchanged under adrenalectomy. By antiphlogistic activity, the derivatives in question compare very favourably to butadion and hydrocortisone, and are similar to prednisolone.