1.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21705217
RESUMO
Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38α have been prepared exploring functional group modifications at the C6 position. Incorporation of aryl and heteroaryl ketones at this position led to potent inhibitors with efficacy in in vivo models of acute and chronic inflammation.