Assuntos
Antioxidantes/uso terapêutico , Biopterinas/análogos & derivados , Biopterinas/uso terapêutico , Rejeição de Enxerto/prevenção & controle , Sobrevivência de Enxerto/efeitos dos fármacos , Transplante de Coração , Animais , Avaliação Pré-Clínica de Medicamentos , Rejeição de Enxerto/metabolismo , Interferon gama/metabolismo , Camundongos , Camundongos Endogâmicos C3H , Camundongos Endogâmicos C57BL , Óxido Nítrico Sintase/metabolismo , Óxido Nítrico Sintase Tipo II , Fatores de Tempo , Transplante Homólogo , Fator de Necrose Tumoral alfa/metabolismoRESUMO
Two experiments investigated cardiovascular responses to several common neuromuscular blocking compounds. Experiment 1, employing 16 cats, assessed ganglionic transmission in sympathetic and parasympathetic systems controlling heart rate and blood pressure after d-tubocurarine chloride (d-T.C.), dimethyl d-tubocurarine iodide (D. d-T.I.), succinylcholine chloride (SC), or saline. Cardiovascular responses to sympathetic stimulation were essentially unaffected at drug levels that blocked evoked electromyograms; however, vagally evoked bradycardia and corresponding blood pressure decrease were blocked by d-T.C. and redduced by D. d-T.I. and SC. Experiment 2 compared heart responses of 12 cats under the same blocking compounds during differential classical aversive conditioning. Differential conditioned responses and unconditioned responses occurred under D. d-T.I., less under SC, but not under d-T.C. However, animals trained under d-T.C. and tested under D. D-T.I. showed differential conditioned responses.