RESUMO
Gallic acid (1) and methyl gallate (2) were isolated from Juca, a Brazilian folk medicine, fruits of Caesalpinia ferrea MART (Leguminosae), decreased significantly the average number of papillomas per mouse in the experiment of the promoting effects of 12-O-tetra- decanoylphorbol-13-acetate (TPA) on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene (DMBA).
Assuntos
Anticarcinógenos/farmacologia , Caesalpinia/química , Ácido Gálico/análogos & derivados , Medicina Tradicional , Extratos Vegetais/farmacologia , Neoplasias Cutâneas/induzido quimicamente , Neoplasias Cutâneas/prevenção & controle , 9,10-Dimetil-1,2-benzantraceno/farmacologia , Animais , Anticarcinógenos/química , Brasil/etnologia , Feminino , Frutas/química , Ácido Gálico/isolamento & purificação , Ácido Gálico/farmacologia , Camundongos , Camundongos Endogâmicos ICR , Papiloma/induzido quimicamente , Papiloma/prevenção & controle , Fitoterapia , Extratos Vegetais/química , Acetato de Tetradecanoilforbol/farmacologiaRESUMO
The anti-tumor promoting effects of fruits of Caesalpinia ferrea MART. (Leguminosae) were tested by the in vitro Epstein-Barr virus early antigen (EBV-EA) activation assay, and its active constituents were identified as gallic acid (1) and methyl gallate (2). A total of 49 related compounds of 1 and 2 were analysed for the effects by this assay, and the structure activity relationships have been proposed. Three acetophenone derivatives, 2,6-dihydroxyacetophenone (48), 2,3,4-trihydroxyacetophenone (50) and 2,4,6-trihydroxy- acetophenone (51) were found to show potent inhibitory activity.
Assuntos
Antígenos Virais/efeitos dos fármacos , Caesalpinia , Ácido Gálico/análogos & derivados , Neoplasias/tratamento farmacológico , Fitoterapia , Preparações de Plantas/farmacologia , Antígenos Virais/metabolismo , Bioensaio , Ácido Gálico/metabolismo , Humanos , Neoplasias/metabolismo , Preparações de Plantas/química , Preparações de Plantas/uso terapêutico , Relação Estrutura-AtividadeRESUMO
Cancer chemoprevention by phytochemicals may be one of the most feasible approaches for cancer control. For example, phytochemicals obtained from vegetables, fruits, spices, teas, herbs and medicinal plants, such as carotenoids, phenolic compounds and terpenoids, have been proven to suppress experimental carcinogenesis in various organs. These candidates should be evaluated by intervention studies, before acceptance as cancer preventive agents for human application. Phytochemicals may also be useful to develop "designer foods" or "functional foods" for cancer prevention. We are now planning animal foods, such as meats, eggs and milk, which contain anti-carcinogenic phytochemicals. In prototype experiments, expression of genes for synthesis of phytochemicals, such as phytoene and limonene, has been successful in cultured animal cells.