YOGA AND THE INTERPLAY BETWEEN ATTENTIONAL LOAD AND EMOTION INTERFERENCE.

This study compared 45 yoga practitioners (M age = 29.7 yr., SD = 6.4) and 45 matched controls (M age = 29.3 yr., SD = 6.2) on the performance of a behavioral task that assessed negative emotion interference during a high- and a low-attentional demand condition, as well as on state and trait anxiety scores. Outcomes were also compared between beginner and advanced practitioners. For the behavioral task, the final sample comprised 36 yoga and 38 control participants. The yoga group presented lower emotion interference in the high attentional condition, compared to the low attentional condition; rated emotional images as less unpleasant, compared to controls; and reported lower state and trait anxiety scores relative to controls. Also, emotion interference in the low attentional condition was lower among advanced practitioners and state anxiety was lower among practitioners attending more than two weekly yoga classes. The results suggested that yoga may help improve self-regulatory skills and lower anxiety. The psychological mechanisms underlying the relationship between yoga and emotion regulation should be further investigated in longitudinal studies.

The footfault test as a screening tool in the 6-hydroxydopamine rat model of Parkinson's disease.

The administration of 6-hydroxydopamine (6-OHDA) into the nigrostriatal pathway is a rat model of Parkinson's disease (PD). The footfault test is a behavioural task in which rodents have their motor functions assessed. Here, we observed that unilaterally 6-OHDA-lesioned animals show a context-induced ipsilateral rotational behaviour when placed on the footfault apparatus for 3 min and this may be used as index to detect lesioned animals. Our results showed a sensitivity and specificity of 100% for lesions higher than 94% and 64%, respectively (ROC curve: AUC=0.988). A binary logistic regression model showed an expB=1.116 (95% CI, 1.007-1.236) and C=-9.081+/-4.554 (p=0.046) using the nigral tyrosine hidroxylase immunocontent as standard (each unit represents a 10%-lesion extension). Additionally, the footfault test was more sensitive than apomorphine challenging at 1mg/kg when these tests were carried out days apart and it was less sensitive than methylphenidate at 40 mg/kg (sign test, p<0.05). Therefore, the footfault test may be very useful in the PD animal model for screening animals since it is fast and simple and it does not require a drug to induce rotational activity.