Homeopathic Ankle Dislocation for Treatment of Unstable Trimalleolar Fractures Involving Posterior Die-Punch Fragment: A Retrospective Cohort Study.

OBJECTIVES: Unstable trimalleolar fractures are relatively complex and more difficult to manage if die-punch fracture is present. We aimed to evaluate the curative effect of homeopathic ankle dislocation on the unstable trimalleolar fractures involving posterior die-punch fragments. METHODS: A total of 124 patients diagnosed with unstable trimalleolar fractures combined with post-die punch fragment between June 2008 and June 2020 were retrospectively included. Patients who received homeopathic ankle dislocation were named as the experimental group, and patients who accepted conventional treatment were control group. The fracture healing time, wound healing, American Orthopedic Foot and Ankle Society ankle-hindfoot scale (AOFAS), visual analogue scale (VAS), the Kellgren-Lawrence arthritis grading scale (KLAGS) and short-form 36 score (SF-36) scores were collected. Student t-test was used for fracture healing time. Wound healing and SF-36 were compared using the Mann-Whitney test. Repeated measurement analysis of variance (ANOVA) was used for AOFAS and VAS. χ2-test was used for KLAGS. RESULTS: AOFAS showed statistically significant differences between the two groups (p = 0.001). In non-weight-bearing and weight-bearing conditions, VAS scores were significant different between the two groups, and there was an interaction between group and time point (p < 0.001). The experimental group was superior to the control group in terms of physical function (p = 0.022), role-physical (p = 0.018), general health (p = 0.001) and social function (p = 0.042).The operation time of experimental group was shorter than that of control group (p < 0.001). CONCLUSION: Homeopathic ankle dislocation is used for the unstable trimalleolar fractures involving posterior die-punch fragment, which can provide better functional outcomes while shortening the operation time and recovery period.

[Studies on preparation and dissolution test in vitro of sustained-release dropping pills of curcumin].

OBJECTIVE: To study the prescription and technique of sustained-release dropping pills of curcumin and inspect their release property in vitro. METHODS: The orthogonal test was used to screen the prescription and technique which were definited with the colligation evaluation of release and formation of dropping pills. RESULTS: The optimization of prescription and technique were as follows: stearic acid 70 mg, glycery monostearate 25 mg, solutol 6 mg, viscosity of cooling liquid was 100 mm2/s; the temperature of material liquid was 80 degrees C; the cooling temperature was 30 - 0 degrees C; the dropping speed was (21 +/- 2) dripping/min. The release behavior of sustained-release dropping pills of curcumin coincidented with Higuchi equation well and the character of sustained-release was transparent. CONCLUSIONS: The sustained-release dropping pills of curcumin have good property of sustained-release in vitro and their release behavior in vivo need to be inspected.

[The synergistic and toxicity-reducing effects of zhenqifuzheng injection on mice with 60Co radiotherapy].

OBJECTIVE: To study the synergistic and toxicity-reducing effect of zhenqifuzheng (ZQFZ) injection on mice with 60Co radiotherapy. METHODS: The tumor-bearing mice models with Hepatoma-22 were established. Mice in 60Co control group were treated by 60Co; ZQFZ injection were administered with dosages of 1.5, 3.0, 6.0 g/(kg x d) through ip for 7 days,then the inhibitory rate, the number of WBC,the spleen and thymus index were calculated. Meanwhile,the MDA content and SOD activity in serum were determined. Phagocytosis of mononuclear macrophage was determined with carbon particle clearance test. RESULTS: Each dose of ZQFZ injection inhibited the development of tumor, and had synergism with 60Co. High dose of ZQFZ injection increased the number of WBC, and the spleen index in all ZQFZ groups increased (P < 0.05 or P < 0.01). Whereas, no significant difference was found of thymus index in all groups, and the changes of MDA content and SOD activity induced by 60Co were reversed obviously by three doses of ZQFZ (P < 0.05 or P < 0.01). Meanwhile, non-specific immunity was enhanced in different degree in three doses of ZQFZ groups (P < 0.01). CONCLUSION: ZQFZ injection can increase the activity of non-specific immunity, improve the anti-tumor effects and meanwhile attenuate the toxicity of 60Co, which may be related to the antagonistic effect on lipid peroxidation.