RESUMO
The effect of multivitamin supplementation on thiamin, riboflavin and retinol nutrition was studied in ten male chronic pediatric patients at Ramathibodi Hospital. MTV forte (Government Pharmaceutical Organization) was given 1 tablet daily for ten days and the effect was compared with the preceding ten-day control period. Anthropometric biochemical, clinical and dietary assessments were performed throughout the study. Biochemical assessments of vitamin nutrition at the beginning and the end of a 10-day non-supplementation period revealed multiple vitamin deficiencies in the subjects, though clinical manifestation was not seen. Hospital diets improved vitamin nutrition of some patients but most of them still showed subclinical vitamin deficiencies. Improvement of vitamin nutrition was clearly shown in most patients after MTV supplementation. Multiple vitamin supplements should be prescribed in high-risk patients since there was no definite pattern of vitamin deficiencies in various diseases and early detection of vitamin deficiency was difficult to perform. The dosage between 1-2 times of RDA was considered adequate in most of our patients.
Assuntos
Cardiopatias/fisiopatologia , Doenças do Sistema Nervoso/fisiopatologia , Estado Nutricional , Vitaminas/uso terapêutico , Adolescente , Criança , Doença Crônica , Humanos , MasculinoAssuntos
Beriberi/etiologia , Flavonoides , Alimentos , Tiamina/antagonistas & inibidores , Adolescente , Animais , Areca , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/uso terapêutico , Beriberi/prevenção & controle , Fenômenos Químicos , Química , Dieta/efeitos adversos , Feminino , Fermentação , Peixes , Temperatura Alta , Humanos , Taninos Hidrolisáveis , Masculino , Fenóis/farmacologia , Plantas Medicinais , Polímeros/farmacologia , Polifenóis , Ratos , Chá/efeitos adversos , Deficiência de Tiamina/sangue , Deficiência de Tiamina/tratamento farmacológico , Tiamina Pirofosfato/farmacologia , Transcetolase/sangueRESUMO
Bio Rex 70 column chromatography and high voltage paper electrophoresis were used to fractionate and define the reaction products of thiamin-tannic acid and thiamin-tea mixtures. Fractions separated indicated the presence of (a) thiamin-tannic acid adduct(s) and several modified forms of thiamin among the products. Using radioactive thiamin and determining the intact form by scintillation counting, the extent of thiamin modification under various conditions was compared with previous results as determined by the thiochrome method. The elution profile of the thiamin-tea mixture and the electrophoretogram showed features similar to those of the thiamin-tannic acid mixture. The effectiveness of the tea extract and tannic acid in modifying thiamin was compared. Ascorbic acid was found to protect the modification of thiamin by tannic acid, not only at acidic pH as previously found, but also at neutral pH, thus making vitamin C a strong candidate for the protection of thiamin in the alimentary system.