Ten weeks of Capsicum annuum L. extract supplementation did not change adipose tissue-derived hormones, appetite, body composition, and muscle strength when combined with resistance training in healthy untrained men: A clinical trial study.

Capsiate (CAP) is a nonpungent capsaicin analog (Capsicum annuum L. extract) that has been studied as a potential antiobesity agent. However, the interaction between chronic CAP supplementation and resistance training is not clear. The purpose of this study was to examine the changes in adipose tissue-derived hormones, body composition, appetite, and muscle strength after 10 weeks of resistance training, combined with chronic CAP supplementation in healthy untrained men. We hypothesized that CAP could induce higher benefits when combined with resistance training after 10 weeks of intervention compared to resistance training alone. Twenty-four young men (age, 22.0 ± 2.9) were randomized to either capsiate supplementation (CAP = 12 mg/day) or placebo (PL), and both groups were assigned to resistance training. Body composition, leptin and adiponectin concentrations, subjective ratings of appetite, energy intake, and exercise performance were assessed at before and after 10 weeks of progressive resistance training. There was a significant increase in body mass (P < .001), fat-free mass (CAP: 58.0 ± 7.1 vs. post, 59.7 ± 7.1 kg; PL: pre, 58.4 ± 7.3 vs. post, 59.8 ± 7.1 kg; P < .001), resting metabolic rate (CAP: pre, 1782.9 ± 160.6 vs. post, 1796.3 ± 162.0 kcal; PL: pre, 1733.0 ± 148.9 vs. post, 1750.5 ± 149.8 kcal; P < .001), maximal strength at 45 leg press (P < .001) and bench press (P < .001) in both groups, but no significant (P > .05) supplementation by training period interaction nor fat mass was observed. For subjective ratings of appetite, energy intake, leptin, and adiponectin, no significant effect of supplementation by training period interaction was observed (P > .05). In conclusion, 10 weeks of resistance training increased total body weight, muscle mass, and maximum strength in healthy untrained men; however, CAP supplementation (12 mg, 7 days per week) failed to change adipose tissue-derived hormones, appetite, body composition and muscle strength in this population. Registered under Brazilian Registry of Clinical Trials (RBR-8cz9kfq).

Acute Response to Capsiate Supplementation at Rest and during Exercise on Energy Intake, Appetite, Metabolism, and Autonomic Function: A Randomized Trial.

OBJECTIVE: The purpose of the present study was to examine the effect of capsiate supplementation on energy intake, self-reported appetite-related sensations, energy expenditure, fat oxidation, and autonomic parameters with and without an exercise intervention. METHODS: Thirteen healthy men completed four randomized trials: two trials for the control condition (without exercise), one with capsiate supplementation (CTRLcap) and one with a placebo (CTRLpla), and two trials for the exercise condition, one with capsiate supplementation (EXcap) and one with placebo (EXpla). Exercise sessions were performed 150 min after the consumption of a standardized breakfast, and supplementation 115 min after consumption of breakfast. An ad libitum buffet was offered 200 min following the completion of the standardized breakfast, and energy intake (EI) and relative energy intake (REI) (relative energy intake = energy intake - energy expenditure related to exercise) were evaluated. RESULTS: There were no significant effects on EI, self-reported appetite sensations, fat oxidation, and energy expenditure. REI was reduced in conditions involving EX when compared to CTRL. A low-frequency to high-frequency ratio for heart rate variability was higher in CTRLcap (1.6 ± 1.1) vs. CTRLpla (1.2 ± 0.9) (p = 0.025; d = 0.39). CONCLUSION: Acute capsiate supplementation combined with aerobic exercise has limited effects on the examined variables (EI, REI, fat oxidation, energy expenditure, and autonomic parameters), while changes in the autonomic nervous system function in the absence of exercise may have occurred without influencing other variables. CLINICAL TRIAL REGISTRATION: ensaiosclinicos.gov.br number, RBR-5pckyr https://ensaiosclinicos.gov.br/rg/RBR-5pckyr.

Energy System Contributions in Upper and Lower Body Wingate Tests in Highly Trained Athletes.

PURPOSE: This study compared the energy system contributions and relationship between mechanical and energy system variables in upper and lower body Wingate tests (WAnT) in judo athletes. METHOD: Eleven male judo athletes (18 ± 1 years, 174.3 ± 5.3 cm, 72.6 ± 9.9 kg, 11.8 ± 1.7% body fat) attended two laboratory sessions to perform two WAnT (upper and lower body) and two incremental tests (upper and lower body). The energy contributions of the oxidative, glycolytic, and phosphagen (ATP-PCr) systems were estimated based on oxygen consumption ( V˙O2 ) during WAnT, delta of lactate, and the fast phase of excess V˙O2 , respectively. RESULTS: The upper and lower body presented similar results of oxidative (21 ± 4% vs 23 ± 3%) and ATP-PCr system contributions (29 ± 6% vs 32 ± 5%). The glycolytic system contribution (50 ± 5% vs 45 ± 4%) was higher in the upper body. The variance of mechanical variables in upper body was explained by glycolytic (R2 = 0.49-0.62) and oxidative systems (R2 = 0.44-0.49), whereas the variance of mechanical variables in lower body was explained by ATP-PCr (R2 = 0.41-0.55) and glycolytic systems (R2 = 0.62-0.94). CONCLUSIONS: During WAnT, the glycolytic system presented the major energy contribution, being higher in the upper body. Moreover, mechanical and energy system variables presented a distinct relationship when comparing upper and lower body WAnT.

Energy-System Contributions to Simulated Judo Matches.

PURPOSE: To estimate the contribution of the 3 energy systems to simulated judo matches. METHODS: Twelve judo athletes (18 ± 1 y, 175.1 ± 5.3 cm, 74.3 ± 10.5 kg, 11.7% ± 1.5% body fat, 8 ± 2 y of practice) performed 5 combats with different durations (1, 2, 3, 4, and 5 min), against the same opponent, on different days and blinded to the duration. The estimated energy contributions for the oxidative, glycolytic, and ATP-PCr systems were calculated based on oxygen uptake (V̇O2) during activity, Delta of lactate, and the fast phase of excess V ̇ O2, respectively. Analysis of mixed models for repeated measures was used to compare the contribution of the 3 energy systems and different durations of judo matches, followed by a post hoc Bonferroni test. RESULTS: The oxidative system's contribution (70%) was higher than those of the glycolytic (8%; P < .001) and ATP-PCr (21%; P < .001) energy systems (in all durations), and the ATP-PCr contribution was higher than that of the glycolytic energy system (up to 3 min). In addition, during the match there was an increase in the oxidative (from 50% to 81%; P < .001), a decrease in the ATP-PCr (from 40% to 12%; P < .001), and maintenance of the glycolytic contributions (between 6% and 10%). CONCLUSIONS: There is a predominance of the oxidative system to supply the energy cost of judo matches from the first minute of combat up to the end, compared with the anaerobic systems.

Brazilian Jiu-Jitsu Simulated Competition Part I: Metabolic, Hormonal, Cellular Damage, and Heart Rate Responses.

The aim of this study was to analyze physiological responses in Brazilian jiu-jitsu athletes during simulated competition. To this end, 10 athletes (age: 28 ± 4 years, body mass: 81.8 ± 7.4 kg, body fat: 13.0 ± 4.8%, systematic practice: 11 ± 4 years) were analyzed in simulated competition (4 matches of 10 minutes). Blood samples were taken to assess energy demand, hormonal responses, and cell damage. Additionally, the heart rate variability (HRV) response was analyzed. The main results show that in simulated competition, during the last matches, athletes had lower lactate (p < 0.001), epinephrine (p < 0.001), norepinephrine (p < 0.001), and insulin (p = 0.002) concentrations. Increases observed in creatine kinase (p < 0.001), aspartate aminotransferase (p < 0.001), alanine aminotransferase (p = 0.007), and creatinine (p < 0.001) seen, especially, in the last matches are indicative of possible cell damage. The HRV reflected a decrease in the RR medium (average of the normal R-R intervals) (p = 0.001) during the competition. Thus, it is concluded that successive matches from competition generate a gradual decrease of adrenergic and glycolytic activities, which is accompanied by a gradual increase in cell damage markers and decrease in the RR medium of the HRV.

Differences in metabolic and inflammatory responses in lower and upper body high-intensity intermittent exercise.

PURPOSE: The purpose of this study was to compare the effect of upper and lower body high-intensity intermittent exercise (HIIE) on immunometabolism profile. METHODS: Seven male judo athletes completed two experimental sessions separated by at least 48 h. The athletes completed four bouts of the upper and lower body Wingate tests separated by 3-min recovery periods. The blood samples were collected at rest and immediately after the fourth bout of lower and upper body Wingate tests. Serum was analysed for IL-1ra (Interleukin-1 Receptor Antagonist), interleukins (IL-1) IL-2, IL-4, IL-6, IL-10, TNF-α (tumor necrosis factor alpha), cortisol, glucose, and NEFA (non-ester fatty acid). Peak power (maximum power attained during the 30 s test), mean power were calculated. In addition, after 1 and 2.5-min of each Wingate bout, blood samples from the ear lobe were collected for lactate analysis. RESULTS: Our data demonstrated that lower body HIIE promoted a greater metabolic rate (values pre- vs. post-Wingate, for lactate: 1.02 ± 0.16 vs. 14.44 ± 1.08 mmol/L; for glucose: 112.5 ± 16.7 vs. 147.9 ± 23.5 mg/dL) and resulted in higher mechanical (mean power: 621 ± 46 vs. 427 ± 40 W, peak power: 794 ± 61 vs. 602 ± 109 W) performance compared to the upper body HIIE (lactate: 0.85 ± 0.18 vs. 12.69 ± 0.74 mmol/L; for glucose: 115.3 ± 20.4 vs. 123.7 ± 28.6 mg/dL; mean power: 480 ± 46 vs. 341 ± 45 W; and peak power: 672 ± 83 vs. 501 ± 120 W), but NEFA showed a similar response to both conditions, with increased IL-10 levels. CONCLUSIONS: In conclusion, our results demonstrated that despite the higher performance in lower body HIIE, the inflammatory response did not differ between exercise modalities.

Physiological and performance responses to intermittent Uchi-komi in Judo.

The objective of this study was to compare the physiological and performance responses with different judo techniques and time structure uchi-komi (technique entrance) protocols. Ten judo athletes (25 ± 6 years old, 73 ± 9 kg, 173 ± 5 cm, and 15 ± 6 years of judo experience) were submitted to 9 all-out uchi-komi sessions. Three techniques (o-uchi-gari, seoi-nage, and harai-goshi) and 3 different time structures (18 × 10 seconds/10 seconds, 9 × 20 seconds/20 seconds, and 6 × 30 seconds/30 seconds) were randomly assigned. Two-way and 3-way analyses of variance with repeated measurements and the Bonferroni test were used. The significance level was fixed at 5%. There was no effect of the time structure or the technique on the absolute energy expenditure (p > 0.05), which can be attributed to the all-out characteristic of the exercise. However, more repetitions were executed during the o-uchi-gari protocol (F = 19; p < 0.001; η = 0.32) compared with harai-goshi and seoi-nage (p < 0.001 for both comparisons). Oxygen consumption differed over time during the activity (F = 767; p < 0.001; η = 0.904), with lower values during the first minute (32.51 ± 3.21 ml·kg·min) compared with the second (41.47 ± 4.20 ml·kg·min) and third minutes (42.96 ± 4.29 ml·kg·min), and lower values were recorded in the second minute compared with the third minute (p < 0.001 for all comparisons). There was also an effect of technique on the total energy expenditure per repetition (F = 6; p = 0.001; η = 0.128), with o-uchi-gari resulting in lower values compared to seoi-nage (p = 0.003), as the former technique does not involve torso rotation and knee flexion, while the latter technique does. These training protocols resulted in similar oxygen uptake and heart rate responses compared to match simulations, and they can be used to simulate the match demand.