1.
Bioorg Med Chem Lett
; 15(16): 3713-6, 2005 Aug 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15946843
RESUMO
Two isomers of the hexahydro-tetraazaacenaphthylene templates (1 and 2) are presented as novel, potent, and selective corticotropin releasing factor-1 (CRF1) receptor antagonists. In this paper, we report the affinity and SAR of a series of compounds, as well as pharmacokinetic characterization of a chosen set. The anxiolitic activity of a selected example (2ba) in the rat pup vocalization model is also presented.