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J Agric Food Chem ; 66(40): 10598-10607, 2018 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-30217109

RESUMO

Spiral dextrin subfraction (SD-40) obtained through enzyme debranching and gradient ethanol precipitation could interact with vitamin E (VE) or soy isoflavone (SIO) to form V-type inclusion complexes. The formation of two inclusion complexes was confirmed by Fourier transform-infrared spectroscopy, atomic force microscopy, and differential scanning calorimetry. In this study, an in vitro gastrointestinal model was used to investigate the breakdown of inclusion complexes and release behavior of bioactive compounds. The results indicated that the two inclusion complexes exhibited a controlled and sustained release behavior during digestion. In addition, the SD-40/VE inclusion complex presented higher stability and stronger antioxidant capacity than the SD-40/SIO inclusion complex. Furthermore, the first and zero order models were applied to understand the release kinetics of VE and SIO from inclusion complexes in the stomach, whereas the first order model was chosen to describe the release of VE and SIO from inclusion complexes in the intestine.


Assuntos
Antioxidantes/química , Dextrinas/química , Composição de Medicamentos/métodos , Trato Gastrointestinal/metabolismo , Isoflavonas/química , Extratos Vegetais/química , Vitamina E/química , Vitamina E/metabolismo , Antioxidantes/metabolismo , Varredura Diferencial de Calorimetria , Digestão , Portadores de Fármacos/química , Composição de Medicamentos/instrumentação , Humanos , Cinética , Glycine max/química , Espectroscopia de Infravermelho com Transformada de Fourier
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