Efeitos do treinamento resistido sobre indicadores de saúde de sobreviventes de câncer de mama / Effects of resistance training on health indicators in breast cancer survivors

O objetivo deste estudo foi investigar os efeitos do treinamento resistido sobre indicadores de saúde em sobreviventes de câncer de mama. Vinte e duas mulheres com histórico de mastectomia e linfadenectomia completaram 12 semanas de treinamento. Avaliações de força, índice de massa corporal, composição corporal, aspectos hematológicos, bioquímicos e de estabilidade de membrana eritrocitária foram realizadas antes e depois do período de treinamento. Em todos os exercícios, ocorreram ganhos significantes de força máxima e resistência de força. Além disso, houve diminuição do percentual de gordura corporal, aumento do percentual de massa magra, redução de eritrócitos, plaquetas e hemoglobina, bem como mudanças desejáveis para todas as variáveis de perfil lipídico. Em conjunto, esses achados destacam o impacto multidimensional do treinamento resistido sobre a saúde de sobreviventes de câncer de mama e revelam a necessidade de monitoramento constante desse público.

The present study aimed to investigate the effects of resistance training on health indicators in breast cancer survivors. Twenty-two women with a history of mastectomy and lymphadenectomy completed 12 weeks of training. Strength, body mass index, body composition, hematological, and biochemical aspects, and erythrocyte membrane stability were performed before and after the training. In all exercises, there were significant gains in maximal force and force endurance. Moreover, there was a decrease in body fat percentage, an increase in lean mass percentage, a reduction in erythrocytes, platelets, and hemoglobin, as well as desirable changes for all lipid profile variables. Altogether, these findings highlight the multidimensional impact of resistance training on the health of breast cancer survivors and reveal the need for constant monitoring of this public.

Application of physical exercise therapies in breast cancer survivors and their effects on the inflammatory profile: A narrative review.

BACKGROUND: One of the adverse effects of cancer treatments is the exacerbation of inflammation, which generates numerous limitations and contributes to the development of several comorbidities and the recurrence of cancer itself. Physical exercise (PE) has been proposed as an efficient complementary strategy to combat the inflammatory effects of oncological treatments and to prevent the development of comorbidities, but its adequate application in breast cancer survivors (BCS) requires the establishment of consensuses and practical recommendations. OBJECTIVE: This study aimed to review the randomized controlled trials that evaluated the influence of PE in the inflammatory profile of BCS. METHODS: The search for articles published between 1999 and 2020 was done in PsycINFO, PubMed, Cochrane, Science Direct, and Scopus databases. RESULTS: Current knowledge reveals the effectiveness of PE in the functional independence and health of BCS. Evidence of the capacity of PE to improve the inflammatory profile and the immune response in BCS has also been described. However, the heterogeneity of the studies regarding structural training variables, types of exercise, stages of intervention, and severity of the disease, still do not allow the establishment of precise guidelines for the prescription and progression of exercise to improve the inflammatory process in BCS. DISCUSSION: . This review suggests a possible strategy to be used in the assessment, training prescription, and rehabilitation of BCS, to support the development of new studies and the work of exercise professionals in the prescription and application of physical training to improve health and inflammatory status in BCS.

Effects of combined and resistance training on the inflammatory profile in breast cancer survivors: A systematic review.

OBJECTIVE: The present systematic review aimed to verify the effect of resistance and combined training on the inflammatory profile of breast cancer survivors. DESIGN: The searches were made on the platforms PsycINFO, PubMed, Cochrane, Science Direct and Scopus, from 1996 to 2017, using the keywords: cancer survivors, cancer treatment, cancer patients, breast cancer, inflammation, inflammatory profile, immune function, resistance training, strength training, weight training, physical activity, concurrent training and combined training. References of selected articles were also considered. Seven studies fulfilled the criteria adopted for analysis. RESULTS: None of these studies have shown reduced inflammatory markers in breast cancer survivors undergoing combined or isolated resistance training. CONCLUSIONS: It is not yet possible to conclude which resistance and/or combination training protocol is capable of improving the short-term inflammatory profile in this population. Future studies should seek to establish how structural training variables (intensity, volume, density, intra- and inter-series recovery, among others) act on anti-inflammatory processes in breast cancer survivors.

[Interference of the blood glucose control in the transition between phases I and II of lactogenesis in patients with type 1 diabetes mellitus]. / Interferência do controle glicêmico na transição entre as fases I e II da lactogênese em pacientes com diabetes melito tipo 1.

Lactogenesis is constituted by phases I and II. The transition between those phases is characterized by an increase of the lactose concentration in the colostrum. This study aimed to evaluate the interference of type 1 Diabetes mellitus in the transition between phases I and II of the lactogenesis. The lactose concentration was determined in colostrum samples of 11 puerperal women with pre-gestational Diabetes mellitus and 19 without the disease, during the five first days of the puerperium. The lactose concentration was determined by reaction with picric acid. In both groups there were progressive increases in the lactose levels along the time; however, the increase was significantly lower in the 3rd and 5th days for the group of the women with diabetes. The analysis of the transition between the lactogenesis phases revealed that the puerperal diabetic women with inadequate glycemic control presented a time delay of 18 hours to reach phase II, making difficult the establishment of breastfeeding.

Interferência do controle glicêmico na transição entre as fases I e II da lactogênese em pacientes com diabetes melito tipo 1 / Interference of the blood glucose control in the transition between phases I and II of lactogenesis in patients with type 1 diabetes mellitus

A lactogênese é constituída pelas fases designadas como I e II. A transição entre essas fases é caracterizada pelo aumento da concentração de lactose no colostro. Este estudo teve como objetivo analisar a interferência do diabetes melito tipo 1 (DM1) na transição entre as fases da lactogênese. A concentração de lactose foi determinada em amostras de colostro de 11 puérperas portadoras de DM1 e de 19 puérperas sem a doença, durante os cinco primeiros dias do puerpério. A determinação da concentração da lactose foi feita pela reação com ácido pícrico. Em ambos os grupos houve aumento progressivo da concentração da lactose em função do tempo; entretanto, o aumento foi significativamente menor no terceiro e no quinto dia no grupo das portadoras de diabetes. A análise da transição de fases da lactogênese revelou que as puérperas portadoras de diabetes melito com controle glicêmico inadequado apresentaram atraso de 18 horas para alcançar a fase II da lactogênese, dificultando o estabelecimento do aleitamento materno.

Lactogenesis is constituted by phases I and II. The transition between those phases is characterized by an increase of the lactose concentration in the colostrum. This study aimed to evaluate the interference of type 1 Diabetes mellitus in the transition between phases I and II of the lactogenesis. The lactose concentration was determined in colostrum samples of 11 puerperal women with pre-gestational Diabetes mellitus and 19 without the disease, during the five first days of the puerperium. The lactose concentration was determined by reaction with picric acid. In both groups there were progressive increases in the lactose levels along the time; however, the increase was significantly lower in the 3rd and 5th days for the group of the women with diabetes. The analysis of the transition between the lactogenesis phases revealed that the puerperal diabetic women with inadequate glycemic control presented a time delay of 18 hours to reach phase II, making difficult the establishment of breastfeeding.

Influence of aqueous crude extracts of medicinal plants on the osmotic stability of human erythrocytes.

This work analyzed the effects of the aqueous crude extracts of Artemisia absinthium L., Lippia sp., Bryophyllum sp., Solidago microglossa DC, Cymbopogon citratus DC and Mentha x villosa HUDSON on the osmotic stability of human erythrocytes. Hemolysis was monitored by measurement of absorbance at 540 nm following addition of erythrocytes to NaCl solutions of varying concentration. Absorbance was fitted to sigmoid regression curves given by the Boltzmann equation, and hemolysis was characterized by the NaCl concentration leading to lysis of 50% of cells (H(50)), and by the intensity (H) and the amplitude (dS) of the lysis effect. The parameters were determined in the absence and presence of the crude extracts. The extracts of Artemisia absinthium, Lippia sp., C. citratus and M. villosa protected human erythrocytes against hypotonic shock, as evidenced by a decrease in the values of H and H(50) compared to the control solution (p<0.05). The extracts of Bryophyllum sp. and S. microglossa enhanced hemolysis, since their H(50) values were higher than in the control group (p<0.05), but they also showed protective effects, as evidenced by a decrease in H and an increase in dS.

Systematic use of Solidago microglossa DC in the cicatrization of open cutaneous wounds in rats

Many popular medicinal plants have been used indiscriminately without a solid scientific basis for their efficacy, as is the case of Solidago microglossa DC, populary known as arnica-do-Brasil or simply arnica. This plant is used to treat inflammation and to accelerate the healing of wounds. In this work we examined the effect of daily intraperitoneal applications of a crude aqueous extract of arnica on the cicatrization of open cutaneous wounds in Wistar rats. Male Wistar rats were redomly allocated to a control group that received no drug, a sham group that received only the drug vehicle, and a treatment group that receveid daily intraperitoneal injections of a saline solution of arnica(16.1mg.kg-1), for 7 or 14 days after excision of a dorsal cutaneous flap. The area of the lesion and the amount of collagen fibers in the wound were monitored. By the 7th day of observation, there were no significant changes in the area of the lesions or in the amount of collagen fibers in the wound. However, by the 14th day of treatment, there was a small but significant reduction in the area of the wound with no significant change in the amount of callagen fiber deposition. The lack of significant changes in the serum levels of alanineaminotransferase and aspartate aminotransferase indicated that Solidago microglossa DC was not hepatotoxic at the dose used. But the LD50 and LD100 for arnica in rats were 54.7 and 86.2mg.kg1, respectively, which were just arnica cannot be used systemically with enough safety to avoid intoxication. The wound-healing effect of arnica must be object of futher investigation using the isolated constituents of the crude extrct.