[Fibrinolytic and thrombolytic properties of a plasminogen activator isolated from the culture broth of calf kidney cells]. / Fibrinoliticheskie i tromboliticheskie svoistva aktivatora plazminogena, vydelennogo iz kul'tural'noi zhidkosti kletok pochki teliat.

Plasminogen activator isolated from cultural liquid of calf renal cells is an enzyme having a fibrinolytic action in vitro and in vivo, provoking a demonstrable thrombolytic effect, which depends on the drug dose, thrombus size and animal's body weight.

[Plasminogen activator from a kidney cell culture]. / Aktivator plazminogena iz kul'tury kletok pochki.

Plasminogen activator (PA) isolated from kidney's cells culture (doses 10 to 5000 IE/kg) induced lysis of experimental thrombi. Lysis time decreased from 214 to 23 min after PA infusion in doses 10 to 700 IE/kg, further doses decrease from 700 to 5000IE/kg does not accelerate lysis time of thrombi. PA infusion in doses mentioned increases the activator activity of plasma and euglobulin lysis time, but does not change the fibrinolytic activity, antiplasmin content and fibrinogen concentration.