Exploring the role of flavonoids in caries-affected dentin adhesion: A comprehensive scoping review.

OBJECTIVES: The aim of this scoping review was to evaluate the available scientific evidence regarding the use of flavonoids in the treatment of caries-affected dentin focusing on bonding to dentin. METHODS: A comprehensive literature search was performed in five databases from March 2022 and updated in April 2023: PubMed, EMBASE, Scopus, Web of Science, and Scielo. Additionally, the references of included studies were manually searched. Gray literature was excluded from the review. STUDY SELECTION: Inclusion criteria included in vitro, in situ, and in vivo studies (animal or human) published in English. Abstracts, reviews, case reports, book chapters, doctoral dissertations, guidelines, and studies using pure plant extracts were excluded. Data collected from the selected studies were summarized and subjected to narrative and descriptive analysis. Out of the 91 studies identified, only 16 studies met the inclusion criteria. RESULTS: The review analyzed eight different flavonoids (hesperidin, galardin, proanthocyanidin, genipin, quercetin, naringin, epigallocatechin-3-gallate, and other catechins subtypes) used as pretreatment or loaded into adhesive systems, primers, and phosphoric acid. The use of flavonoids improved the mechanical properties of the materials and modified the biological properties of the dentin, reducing collagen loss by the inhibition of proteolytic activity of matrix metalloproteinases (MMPs). CONCLUSIONS: Based on the findings of this scoping review, it can be concluded that the use of flavonoids as pretreatment or incorporation into dental materials preserves collagen in the hybrid layer, inhibiting the MMPs activities, modifying the collagen fibrils of the dentin matrix and improving the mechanical properties of the dental adhesive systems. Therefore, it represents a promising approach for promoting dentin biomodification. This can result in more stable bonding of adhesive restorations to caries-affected dentin.

Inhibition of enamel mineral loss by fissure sealant: an in situ study.

OBJECTIVES: This study evaluated the effect of fluoride and non-fluoride sealants on hardness decrease (HD) and marginal adaptation (MA) on enamel substrates after cariogenic challenge. METHODS: Occlusal enamel blocks, from human third molars, were randomly divided into six groups (n=12), according to occlusal fissures condition (S - sound; C - caries-like lesion; CF - caries-like lesion+topical fluoride) and sealants (F - FluroShield; H - Helioseal Clear Chroma). Lesion depths were 79.3±33.9 and 61.3±23.9 for C and CF groups, respectively. Sealants were placed on occlusal surface and stored at 100% humidity (37°C; 24h/d). HD was measured by cross-sectional microhardness analysis at the sealant margin distances: -1 (under sealant), 0 (sealant margin), 1, 2 (outer sealant). Sealant MA was observed by polarized light microscopy and scored according to: 0 - failure (no sealant MA or total sealant loss); 1 - success (sealant MA present). MA and HD were analysed by ANOVA-R and mixed model analysis, respectively. RESULTS: For HD (ΔS), F values (6900.5±3686.6) were significantly lower than H values (8534.6±5375.3) regardless of enamel substrates and sealant margin distances. Significant differences were observed among sealant margin distances: -1 (5934.0±3282.6)<0 (8701.5±6175.7)=1 (8473.2±4299.4)=2 (7761.5±4035.1), regardless of sealant and substrate. MA was similar for all groups (p≥0.05). CONCLUSION: MA was not affected by sealant type or substrate condition, whereas enamel HD was favourably impacted by fluoride in the sealant. In addition, sealants were more effective as a physical barrier than as its chemical potency in reducing enamel HD. CLINICAL SIGNIFICANCE: Sealing with a fluoride material is a recommended procedure to prevent caries of occlusal permanent molars in high-caries-risk patients, even though those exhibiting white spot lesions, since the enamel hardness decrease when fluoride sealant was used in vitro.

Diagnóstico e estratégiasde tratamento de um dente supranumerário e suas implicações para a oclusão: relato de caso clínico / Impact of sodium hipoclorite and EDTA on the qality sealing of composite resin restoration performed in human dentin

A prevalência de dentes supranumerários na população em geral varia entre 1 e 3%. Devido a essa frequência, o cirurgião-dentista e o especialista devem conhecer os sinais patognomônicos da presença de um supranumerário, assim como o tratamento apropriado. A etiologia dessa anomalia ainda não está totalmente entendida, apesar de a proliferação da lâmina dentária ou fatores genéricos estarem envolvidos. Os dentes supranumerários podem causar atraso ou erupção ectópica dos dentes permanentes, podendo alterar tanto a oclusão quanto a estética facial do indivíduo. Nesse sentido, o diagnóstico precoce do dente supranumerário em desenvolvimento torna-se importante para se aperfeiçoar e minimizar o tratamento necessário, reduzindo a extensão da cirurgia e o tempo de tratamento ortodôntico, bem como suas possíveis complicações. O objetivo do presente artigo foi descrever o tratamento adequado de um dente supranumerário superior e o início da intervenção necessária para o alcance da normoclusão, saúde periodontal, estética favorável e estabilidade do tratamento

Aumento da aeração nasal após remoção de hábitos de sucção e terapia miofuncional / Nasal breathing after removing sucking habit and myofunctional therapy

OBJETIVO: avaliar os efeitos da associação entre a remoção de hábitos de sucção e a Terapia Miofuncional Orofacial na ampliação da aeração nasal. MÉTODOS: vinte crianças na faixa de etária de quatro anos a quatro anos e oito meses foram distribuídas em dois grupos denominados de: Grupo REM (submetido apenas à remoção de hábitos) e Grupo TMF (submetido à remoção de hábitos e posteriormente à Terapia Miofuncional Orofacial). O fluxo de ar expirado pelas narinas foi registrado por meio do espelho nasal milimetrado de Altmann e quantificado em papel milimetrado denominado de Bloco de Referência do Espelho de Altmann. Os exames foram realizados em três momentos (pré-tratamento, 60 e 180 dias após). Os resultados foram submetidos à análise estatística, utilizando-se Test t para duas amostras independentes e para dados pareados, considerando nível de significância valores p<0,05. RESULTADOS: pode-se observar que as médias obtidas da quantificação da aeração nasal após os tratamentos foram significativamente maiores no Grupo TMF que no Grupo REM (p< 0,0001). CONCLUSÃO: houve aumento da aeração nasal e conseqüentemente melhora da função respiratória nasal, utilizando a Terapia Miofuncional Orofacial após remoção de hábitos de sucção em crianças na faixa etária de quatro anos.

PURPOSE: to evaluate the influence of removing pacifier and baby bottle sucking habit and Myofunctional Therapy in increasing nasal airing. METHODS: twenty children aged up to four year, were distributed in two groups according to the treatment, and named: REM Group (only submitted to habits removal) and FMT Group (submitted to habits removal and later to Myofunctional Therapy). The data obtained from the air flow expired by the nostrils were obtained by using the millimeter nasal mirror of Altmann and quantified in millimeter paper (reference block). The exams were accomplished in three times (pre-treatment, 60 and 180 days after treatment). The data were submitted to t Test for two independent samples and the paired t Test (p < 0.05). RESULTS: it was observed that the increase of the nasal airing after treatments were significantly superior for the FMT Group than for the REM Group (p < 0.0001). CONCLUSION: Myofunctional Therapy was able to improve increase of nasal airing and consequently enhancement of nasal breathing.

Remoção de hábitos e terapia miofuncional: restabelecimento da deglutição e repouso lingual / Removal of sucking habits and myofunctional therapy: establishing swallowing and tongue rest position

TEMA: hábitos prolongados de sucção de chupeta e mamadeira podem provocar distúrbios miofuncionais como o padrão incorreto de deglutição e repouso lingual. OBJETIVO: estudar os efeitos da associação da Terapia Miofuncional (TMF) e da remoção de hábitos (REM) de sucção na reabilitação da deglutição e repouso lingual. MÉTODO: dois grupos composto por dez crianças de quatro anos a quatro anos e oito meses de idade que inicialmente apresentavam hábitos de sucção de chupeta e mamadeira foram estudados. O grupo denominado REM foi submetido à REM pelo Método de Esclarecimento modificado, enquanto que o grupo denominado TMF também teve os hábitos de sucção removidos pelo mesmo método e foi associada a TMF. Foram realizados exames pré-tratamento, 60 e 180 dias pós-procedimentos. Os dados foram submetidos aos testes estatísticos de Mann-Whitney e Wilcoxon p < 0,05. RESULTADOS: os resultados evidenciaram que o grupo submetido à REM e TMF apresentou adequação dos padrões de deglutição aos 60 dias e 180 dias e correto posicionamento de língua em repouso aos 180 dias, enquanto que o grupo submetido apenas à REM demonstrou adequação do padrão de deglutição apenas aos 180 dias e não apresentou melhora significativa do correto padrão de posicionamento de língua em repouso durante os períodos de avaliação. CONCLUSAO: a TMF associada à REM de sucção de chupeta e mamadeira produziu melhor e mais rápida adequação do padrão de deglutição e de posicionamento lingual em repouso do que apenas a REM de sucção.

[Removal of sucking habits and myofunctional therapy: establishing swallowing and tongue rest position]. / Remoção de hábitos e terapia miofuncional: restabeleciimento da deglutição e repouso lingual.

BACKGROUND: The prolonged habit of pacifier sucking and the prolonged use of feeding bottle may cause myofunctional disorder, such as incorrect swallowing pattern and inadequate tongue rest position. AIM: To study the effect of myofunctional therapy (MFT) associated with the removal of the habit of pacifier sucking and the use of feeding bottle (REM) on the rehabilitation of swallowing and tongue rest position. METHOD: Two groups with ten children, ages ranging from four to four years and eight months, who initially presented a pacifier sucking habit and used the feeding bottle were studied. Children on REM group underwent the process of sucking habits removal using the Modified-Counselling Method, whereas children on MFT group underwent the same procedure associated to myofunctional therapy. Pre-treatment assessments were made, as well as 60 and 180 days post-treatment assessments. Data were analyzed using the statistical tests of Mann-Whitney and Wilcoxon (p < 0.05). RESULTS: Results indicate that children in the MFT group presented adequate swallowing patterns after 60 and 80 days, and presented adequate tongue rest position after 180 days. Children on the REM group, however, presented adequate swallowing pattern only after 180 days and did not present a significant improvement on the tongue rest position during the assessments. CONCLUSION: Myofunctional therapy associated to the removal of sucking habits presented a better and faster improvement of the swallowing pattern and of the tongue rest position.