[Multicentral randomized controlled clinical trials about treatment of perimenopausal syndrome with electroacupuncture of sanyinjiao (SP 6)].

OBJECTIVE: To evaluate the effect of electroacupuncture (EA) of Sanyinjiao (SP 6) on perimenopausal syndrome (PMS). METHODS: Multicentral randomized controlled trials and single blind test were adopted in the present study. A total of 157 PMS patients were randomly divided into EA group (n=81) and medication group (n=76) . EA (2/100 Hz, 8-10 mA) was applied to bilateral Sanyinjiao (SP 6), 3 times a week and for 3 months (mon). Patients of medication group were treated by oral administration of nylestriol, 2 mg/time, twice a mon for 3 mon. For PMS patients, medroxyprogesterone (6 mg/d, for 10 days) was added from the third mon on after the treatment. The therapeutic effect was evaluated by using "symptoms-signs score scale", and changes of serum estradiol (E2), follicle stimulating hormone (FSH) and luteotrophic hormone (LH) were detected by chemiluminescence immune assay. Kupperman index was determined before and after the treatment. RESULTS: In comparison with pre-treatment, Kupperman index of EA group decreased significantly (P < 0.01). After the treatment, contents of serum FSH and LH of EA group decreased significantly (P < 0.01), while serum E2 contents of EA and medication groups increased significantly (P < 0. 01). Serum LH and E2 levels of EA group were significantly lower than those of medication group (P < 0.05). No significant differences were found between two groups in Kupperman index, markedly-effective rates and total effective rates (P > 0.05). CONCLUSION: EA of Sanyinjiao (SP 6) is able to regulate serum E2, FSH and LH levels and effectively improve perimenopausal syndrome.

[Effects of electroacupuncture of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome].

OBJECTIVE: To observe the regulative effect of electroacupuncture (EA) of Sanyinjiao (SP 6) on genito-endocrine in patients with perimenopausal syndrome (PMS). METHODS: A total of 175 PMS patients (157 cases with complete data) were randomized into EA group (n=81) and medication group (n=76) according to multi-center (3 hospitals) and single-blind control trial method. EA (2/100 Hz, 8-10 mA) was applied to bilateral Sanyinjiao (SP 6) for 30 min, 3 times every week, with one month being a therapeutic course, 3 courses altogether. Patients in medication group were ordered to take nilestriol (2 mg, twice/month for 3 months) and medrysone (2 mg, t. i. d. for 10 days from the 3rd month on). Serum estradiol (E) 2, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were detected with a chemiluminescence immo-analysis system. RESULTS: After EA treatment, serum FSH and LH contents decreased significantly and serum E2 increased considerably (P < 0.001) compared with its basic values. Comparison between two groups showed that FSH, LH and E2 levels in EA group were significantly lower than those of medication group (P < 0.05). CONCLUSION: EA of Sanyinjiao (SP 6) has a good regulative effect on reproductive endocrine function in PMS patients.

[Clinical observation on therapeutic effect of electroacupuncture at Sanyinjiao (SP 6) on peri-menopausal syndrome].

OBJECTIVE: To objectively evaluate the effectiveness and safety of electroacupuncture (EA) at Sanyinjiao (SP 6) for treatment of peri-menopausal syndrome. METHODS: All the patients enrolled were randomly divided into a treatment group and a control group. The treatment group were treated with EA at Sanyinjiao (SP 6) for 3 therapeutic courses, thrice each week, 30 min each time, one month constituting one course. The control group were treated with oral administration of nylestriol for 3 months, 2 mg each time, twice each month. For the menopausal patient, medroxyprogesterone was added from the third month of the treatment for 7 days, 6 mg each day. Changes of vasomotorial symptoms, mental symptoms and scores of Kupperman indexes before and after treatment for 1 month, 2 months and 3 months were investigated. RESULTS: EA could significantly decrease the score of Kupperman indexes, improve vasomotorial symptoms and mental symptoms in the patient of peri-menopausal syndrome with no severe adverse effects. The control group in the score of Kupperman indexes was slightly higher than the treatment group with no significant difference between the two groups, but the treatment group in improvement of the vasomotorial symptoms was better than the control group and in improvement of mental symptoms was not as good as the control group. CONCLUSION: EA at Sanyinjiao (SP 6) is effective and safe for treatment of peri-menopausal syndrome.