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1.
Chem Commun (Camb) ; 56(25): 3697, 2020 03 26.
Artigo em Inglês | MEDLINE | ID: mdl-32186575

RESUMO

Correction for 'Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for phototherapy in the second near-infrared window' by Zhou Liu et al., Chem. Commun., 2019, 55, 6523-6526.

2.
Chem Commun (Camb) ; 56(20): 3019-3022, 2020 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-32048647

RESUMO

Nucleus-targeting NPs based on RuO2 (RuO2NPs) were developed by controlling the size and the surface charge of nanoparticles (NPs). This study not only demonstrates a facile approach for the fabrication of ultrasmall CS-RuO2NPs with good biocompatibility and excellent photothermal properties but also their unique potential for the nucleus-targeted low-temperature PTT.


Assuntos
Nanopartículas/química , Imagem Óptica , Óxidos/química , Técnicas Fotoacústicas , Rutênio/química , Temperatura , Núcleo Celular/efeitos dos fármacos , Humanos , Raios Infravermelhos , Células MCF-7 , Óxidos/farmacologia , Tamanho da Partícula , Fototerapia , Rutênio/farmacologia , Propriedades de Superfície
3.
Nat Chem ; 11(11): 1041-1048, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31548671

RESUMO

Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that photoredox catalysis can provide an oxygen-independent mechanism of action to combat this problem. We have designed a highly oxidative Ir(III) photocatalyst, [Ir(ttpy)(pq)Cl]PF6 ([1]PF6, where 'ttpy' represents 4'-(p-tolyl)-2,2':6',2''-terpyridine and 'pq' represents 3-phenylisoquinoline), which is phototoxic towards both normoxic and hypoxic cancer cells. Complex 1 photocatalytically oxidizes 1,4-dihydronicotinamide adenine dinucleotide (NADH)-an important coenzyme in living cells-generating NAD• radicals with a high turnover frequency in biological media. Moreover, complex 1 and NADH synergistically photoreduce cytochrome c under hypoxia. Density functional theory calculations reveal π stacking in adducts of complex 1 and NADH, facilitating photoinduced single-electron transfer. In cancer cells, complex 1 localizes in mitochondria and disrupts electron transport via NADH photocatalysis. On light irradiation, complex 1 induces NADH depletion, intracellular redox imbalance and immunogenic apoptotic cancer cell death. This photocatalytic redox imbalance strategy offers a new approach for efficient cancer phototherapy.


Assuntos
Citocromos c/metabolismo , Neoplasias/metabolismo , Hipóxia Tumoral , Antineoplásicos/química , Antineoplásicos/farmacologia , Biocatálise , Morte Celular/efeitos dos fármacos , Complexos de Coordenação/química , Complexos de Coordenação/farmacologia , Teoria da Densidade Funcional , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Modelos Moleculares , Conformação Molecular , NAD/antagonistas & inibidores , NAD/metabolismo , Neoplasias/patologia , Oxirredução , Processos Fotoquímicos , Hipóxia Tumoral/efeitos dos fármacos
5.
Chem Commun (Camb) ; 55(46): 6523-6526, 2019 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-31099806

RESUMO

Cu2-xSe nanoparticles (Cu2-xSeNPs) were camouflaged with a red blood cell membrane (RBC) to create nanoparticles with improved biocompatibility, longer blood retention times, excellent absorption properties, superior photothermal conversion efficiency (67.2%) and singlet oxygen production capabilities for the synergistic photothermal and photodynamic therapy of cancer in the second near-infrared (NIR-II) window.


Assuntos
Antineoplásicos/uso terapêutico , Membrana Eritrocítica/química , Nanopartículas/uso terapêutico , Neoplasias/tratamento farmacológico , Animais , Antineoplásicos/síntese química , Antineoplásicos/efeitos da radiação , Antineoplásicos/toxicidade , Linhagem Celular Tumoral , Cobre/química , Temperatura Alta , Humanos , Hipertermia Induzida/métodos , Raios Infravermelhos , Camundongos , Nanopartículas/química , Nanopartículas/efeitos da radiação , Nanopartículas/toxicidade , Fotoquimioterapia/métodos , Células RAW 264.7 , Selênio/química , Oxigênio Singlete/metabolismo , Ensaios Antitumorais Modelo de Xenoenxerto
6.
ACS Appl Mater Interfaces ; 7(41): 23278-90, 2015 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-26430876

RESUMO

To enhance the efficacy and optimize the treatment of cancers, the integration of multimodal treatment strategies leading to synergistic effects is a promising approach. The coassembly of multifunctional agents for systematic therapies has received considerable interest in cancer treatment. Herein, Ru(II) complex-functionalized single-walled carbon nanotubes (Ru@SWCNTs) are developed as nanotemplates for bimodal photothermal and two-photon photodynamic therapy (PTT-TPPDT). SWCNTs have the ability to load a great amount of Ru(II) complexes (Ru1 or Ru2) via noncovalent π-π interactions. The loaded Ru(II) complexes are efficiently released by the photothermal effect of irradiation from an 808 nm diode laser (0.25 W/cm(2)). The released Ru(II) complexes produce singlet oxygen species ((1)O2) upon two-photon laser irradiation (808 nm, 0.25 W/cm(2)) and can be used as a two-photon photodynamic therapy (TPPDT) agent. Based on the combination of photothermal therapy and two-photon photodynamic therapy, Ru@SWCNTs have greater anticancer efficacies than either PDT using Ru(II) complexes or PTT using SWCNTs in two-dimensional (2D) cancer cell and three-dimensional (3D) multicellular tumor spheroid (MCTS) models. Furthermore, in vivo tumor ablation is achieved with excellent treatment efficacy under a diode laser (808 nm) irradiation at the power density of 0.25 W/cm(2) for 5 min. This study examines an efficacious bimodal PTT and TPPDT nanoplat form for the development of cancer therapeutics.


Assuntos
Hipertermia Induzida , Raios Infravermelhos , Nanotubos de Carbono/química , Fotoquimioterapia , Rutênio/farmacologia , Animais , Sobrevivência Celular/efeitos dos fármacos , Espectroscopia de Ressonância de Spin Eletrônica , Endocitose/efeitos dos fármacos , Feminino , Células HeLa , Humanos , Camundongos Nus , Nanotubos de Carbono/ultraestrutura , Fótons , Oxigênio Singlete/química , Espectrofotometria Ultravioleta , Esferoides Celulares/efeitos dos fármacos , Esferoides Celulares/patologia
7.
Biomaterials ; 63: 102-14, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26093791

RESUMO

The design and development of functional hybrid nanomaterials is currently a topic of great interest in biomedicine. Herein we investigated the grafting of Ru(II) polypyridyl complexes onto gold nanospheres (Ru@AuNPs) to improve the particles' near infrared (NIR) absorption, and ultimately allow for application in photothermal cancer therapy. As demonstrated in this article, these ruthenium(II) complexes could indeed significantly enhance gold nanospheres' two-photon luminescence (PTL) intensity and photothermal therapy (PTT) efficiency. The best dual functional nanoparticles of this study were successfully used for real-time luminescent imaging-guided PTT in live cancer cells. Furthermore, in vivo tumor ablation was achieved with excellent treatment efficacy under a diode laser (808 nm) irradiation at the power density of 0.8 W/cm(2) for 5 min. This study demonstrates that the coupling of inert Ru(II) polypyridyl complexes to gold nanospheres allows for the enhancement of two-photon luminescence and for efficient photothermal effect.


Assuntos
Complexos de Coordenação/química , Ouro/química , Substâncias Luminescentes/química , Nanopartículas/química , Piridinas/química , Rutênio/química , Neoplasias do Colo do Útero/diagnóstico , Animais , Linhagem Celular Tumoral , Colo do Útero/patologia , Complexos de Coordenação/uso terapêutico , Feminino , Ouro/uso terapêutico , Células HeLa , Humanos , Hipertermia Induzida , Luminescência , Substâncias Luminescentes/uso terapêutico , Camundongos Endogâmicos BALB C , Camundongos Nus , Nanopartículas/uso terapêutico , Nanopartículas/ultraestrutura , Fototerapia , Piridinas/uso terapêutico , Rutênio/uso terapêutico , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/terapia
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