RESUMO
Adrenal androgens, particularly dehydroepiandrosterone (DHEA), may have important regulatory effects on the immune system in humans. This study measured the changes in adrenal steroidogenesis in 13 non-infected cirrhosis patients with sterile ascites and 13 patients with spontaneous bacterial peritonitis and the relation with circulating interleukin-6 (IL-6) levels. Comparisons were made with 10 healthy age-matched control subjects. The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Careful, long-term studies on DHEA administered to cirrhosis patients are needed to assess its safety in improving a number of pathological conditions that complicate liver cirrhosis.
Assuntos
Adjuvantes Imunológicos/sangue , Ascite/sangue , Desidroepiandrosterona/sangue , Hidrocortisona/sangue , Interleucina-6/sangue , Peritonite/sangue , Adjuvantes Imunológicos/biossíntese , Adjuvantes Imunológicos/uso terapêutico , Hormônio Adrenocorticotrópico/sangue , Hormônio Adrenocorticotrópico/imunologia , Análise de Variância , Ascite/etiologia , Infecções Bacterianas/complicações , Infecções Bacterianas/imunologia , Proteína C-Reativa/imunologia , Proteína C-Reativa/metabolismo , Estudos de Casos e Controles , Desidroepiandrosterona/biossíntese , Desidroepiandrosterona/imunologia , Desidroepiandrosterona/uso terapêutico , Egito , Humanos , Hidrocortisona/imunologia , Interleucina-6/imunologia , Testes de Função Renal , Cirrose Hepática/complicações , Cirrose Hepática/tratamento farmacológico , Cirrose Hepática/imunologia , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Peritonite/etiologia , Índice de Gravidade de DoençaRESUMO
The antispasmodic principle of Cymbopogon proximus has been identified as cryptomeridiol (5) from its spectral properties and comparison with an authentic sample.
RESUMO
The acute toxicity of the alcoholic extracts of seeds, roots stems and leaves of the fully mature Corchorus olitorius L. plant was determined in mice by intraperitoneal injection. The cardiac glycosides content of each extract was estimated and the correlation between the two investigated parameters was established. The chronic toxicity of the alcoholic extract of the seeds was determined in term of its haematological and symptomatical effects on mice upon intraperitoneal injection for a period of two months.