Chemical constituents, anti-inflammatory and analgesic activities of iridoids preparation from Phlomoides labiosa bunge.

This study reports the isolation of iridoids and cycloartane glycosides from the aerial parts of Phlomoides labiosa Bunge. Six compounds were isolated and the chemical structures were identified as phlorigidoside С (1), 8-O-acetylharpagide (2), shanzhiside methyl ester (3), cyclosiversioside A (4), cyclosiversioside E (5), and cyclosiversioside C (6). Compounds 4-6 are reported for the first time in this plant. In addition, anti-inflammatory and analgesic activities of iridoid fraction were studied. The sum of iridoids (SI) with intragastric administration is 5.2 and 52.5 times less toxic, than such market drugs as analgin and diclofenac sodium, respectively. In terms of the latitude of analgesic action (LD50/ED50), the SI exceeds analgin by 19.2 times and diclofenac sodium by 16 times. The anti-inflammatory and analgesic activities of the sum of iridoids were confirmed to be effective and nontoxic, and exceed known drugs diclofenac sodium and analgin (metamizole sodium).

Synergistic Behavior of Plant Proteins and Biobased Latexes in Bioplastic Food Packaging Materials: Experimental and Machine Learning Study.

Plant-based proteins are attractive components which may serve as sustainable alternatives to current petrochemical products. Both soy protein and major corn protein, zein, are of interest in food packaging applications due to their sustainability, biodegradation properties, and inherent physicochemical properties. This study discusses the development of bioplastic materials, where it explores the effects of combining zein, soy protein, and plasticizing latexes derived from plant oil-based monomers (POBMs) on properties of resulting bioplastic films. By looking for synergistic effects of soy protein's inherent film formation ability and zein's higher strength, we prepare strong yet flexible soy-zein films as materials, called proteoposites. Incorporation of natural additive POBM-latexes helps to plasticize and hydrophobize the bioplastic films and thus to improve mechanical and barrier properties. Variation of the POBM-latexes' particle size further aims to enhance the performance of resulting bioplastic films. As a result, modified soy-zein proteoposite films with improved moisture resistance, enhanced mechanical behavior, and greater barrier properties were developed. Machine learning-based computational models were utilized in order to find main structural factors affecting the bioplastic's properties and develop a quantitative structure-property relationship model between the physicochemical properties of the film components and the resulted bioplastics' properties and performance. The developed model effectively predicts experimental outcomes with >85% (R2: 0.85) accuracy. The newly synthesized proteoposites confirmed the machine learning model predictions. As a result, proteoposite films made of two plant proteins and modified with POBM-latexes can be considered as an attractive and viable replacement for petrochemical food packaging products.