Postural Control and Verbal and Visual Working Memory Correlates in Nonclinical Psychosis.

INTRODUCTION: Motor and cognitive abnormalities are well documented in psychosis spectrum disorders. Evidence suggests these deficits could be pronounced because of disruptions in the cerebellar-thalamic-cortical-cerebellar (CTCC) circuit, a network thought to be heavily implicated in motor and higher cognitive functioning. Although significant research has been done on this topic in individuals with schizophrenia and those at a clinical high risk for psychosis, much less is known about deficits at the lower end of the spectrum. METHODS: In this study, we extended the understanding of motor abnormalities across the psychosis continuum by examining postural sway deficits in the nonclinical psychosis (NCP) population. Furthermore, we linked these deficits to verbal and visual working memory. High-NCP (n = 37) and low-NCP control (n = 31) participants completed an instrumental balance task, highly sensitive to subtle variations in postural sway, along with a brief working memory battery. RESULTS: We found that high-NCP participants presented with increased postural sway area (i.e., worse postural control) relative to low-NCP controls on a difficult condition (with limited proprioceptive cues), but not on an easier condition. Furthermore, results indicated that the sway area was correlated with poorer performance on working memory tasks in the high-NCP group. CONCLUSION: These findings suggest that CTCC circuit abnormalities are present across the lower end of the psychosis spectrum and that they may be contributing to a range of motor and cognitive behaviors seen in the population. However, evidence suggests that the signs are subtle, and that sensitive assessment devices and challenging conditions may be necessary for detection.

Exercise Treatments for Psychosis: A Review.

Schizophrenia is a devastating mental illness that has profound effects on a person's health and quality of life. Exercise represents a promising new treatment option that may supplement current psychosocial and pharmacological interventions for psychosis. A large body of work suggests that exercise can improve cardio-metabolic and health behavior and facilitate neurogenesis in areas of the brain that are notably impacted by psychosis. Recent efforts to incorporate exercise as either stand-alone or adjunctive treatment for individuals with schizophrenia range from yoga and light stretching to moderately intense walking, bike riding, or team sports. These interventions suggest that moderately intense exercise may be beneficial for improving both positive and negative symptomatology, cognition and functioning. Indeed, exercise may be beneficial for decreasing risk factors for a wide range of health problems often observed in patients with schizophrenia, including weight gain and metabolic syndrome as well as tobacco and substance use. Given the positive results from interventions in schizophrenia patients, there is an impetus for incorporating exercise in the early stages of the disorder. Notably, individuals at ultrahigh risk (UHR) for psychosis report more sedentary behavior and perceive less benefit from exercise; interventions prior to the onset of the disorder may be helpful for increasing health behaviors, perhaps delaying or preventing the onset of psychosis. Taken together, for individuals with psychosis, exercise may provide holistic benefits for the neural to the social impairments.