Transcranial direct current stimulation in physical therapy treatment for adults after stroke: A systematic review.

BACKGROUND: Stroke is a clinical syndrome that can cause neurological disorders due to a reduction or interruption in the blood flow at the brain level. Transcranial direct current stimulation (TDCS) is a non-invasive electrotherapy technique with the ability to modulate the function of nervous tissue. OBJECTIVE: The aim of this review is to analyze the effects derived from the application of the TDCS for post-stroke patients on functionality and mobility. METHODS: The data search was conducted in PubMed, PEDro, Cochrane Library, Web of Science and Scopus between July and August 2023. The search focused on randomized clinical trials conducted in the period of 2019-2023, and according to the selection criteria, seven studies were obtained. RESULTS: The results found are mainly focused on the analysis of the scales Fugl-Meyer Assessment for Upper Extremity and Wolf Motor Function Test. CONCLUSION: The application of TDCS presents benefits in post-stroke individuals on functionality, mobility and other secondary studied variables.

Vitiligo: Pathogenesis and New and Emerging Treatments.

Vitiligo is a complex disease with a multifactorial nature and a high impact on the quality of life of patients. Although there are multiple therapeutic alternatives, there is currently no fully effective treatment for this disease. In the current era, multiple drugs are being developed for the treatment of autoimmune diseases. This review assesses the available evidence on the pathogenesis of vitiligo, and a comprehensive review of treatments available for vitiligo now and in the near future is provided. This qualitative analysis spans 116 articles. We reviewed the mechanism of action, efficacy and safety data of phototherapy, afamelanotide, cyclosporine, phosphodiesterase 4 inhibitors, trichloroacetic acid, basic fibroblast growth factor, tumor necrosis factor (TNF) inhibitors, secukinumab, pseudocatalase and janus kinase (JAK) inhibitors. At the moment, there is no clearly outstanding option or fully satisfactory treatment for vitiligo, so it is necessary to keep up the development of new drugs as well as the publication of long-term effectiveness and safety data for existing treatments.

Digestive glycosidases from cannonball jellyfish (Stomolophus sp. 2): identification and temporal-spatial variability.

Jellyfish are economically important organisms in diverse countries, carnivorous organisms that consume various prey (crustaceans, mollusks, bivalves, etc.) and dissolved carbohydrates in marine waters. This study was focused on detecting and quantifying the activity of digestive glycosidases from the cannonball jellyfish (Stomolophus sp. 2) to understand carbohydrate digestion and its temporal-spatial variation. Twenty-three jellyfish gastric pouches were collected in 2015 and 2016 in the Gulf of California in three localities (Las Guásimas, Hermosillo, and Caborca). Nine samples were in intra-localities from Las Guásimas. Chitinase (Ch), ß-glucosidase (ß-glu), and ß-N-acetylhexosaminidase (ß-NAHA) were detected in the gastric pouches. However, cellulase, exoglucanase, α-amylase, polygalacturonase, xylanase, and κ-carrageenase were undetected. Detected enzymes showed halotolerant glycolytic activity (i = 0-4 M NaCl), optimal pH, and temperature at 5.0 and 30-50 °C, respectively. At least five ß-glucosidase and two ß-N-acetylhexosaminidase were detected using zymograms; however, the number of proteins with chitinase activity is not precise. The annual variation of cannonball jellyfish digestive glycosidases from Las Guásimas between 2015-2016 does not show significant differences despite the difference in phytoplankton measured as chlorophyll α (1.9 and 3.4 mg/m3, respectively). In the inter-localities, the glycosidase activity was statistically different in all localities, except for ß-N-acetylhexosaminidase activity between Caborca and Hermosillo (3,009.08 ± 87.95 and 3,101.81 ± 281.11 mU/g of the gastric pouch, respectively), with chlorophyll α concentrations of 2.6, 3.4 mg/m3, respectively. For intra-localities, the glycosidase activity did not show significant differences, with a mean chlorophyll α of 1.3 ± 0.1 mg/m3. These results suggest that digestive glycosidases from Stomolophus sp. 2 can hydrolyze several carbohydrates that may belong to their prey or carbohydrates dissolved in marine waters, with salinity over ≥ 0.6 M NaCl and diverse temperature (4-80 °C) conditions. Also, chlorophyll α is related to glycosidase activity in both seasons and inter-localities, except for chitinase activity in an intra-locality (Las Guásimas).

Canales dominantes de percepción del conocimiento. Influencia en la evaluación del aprendizaje de la inmunología / Knowledge Perception Dominant Channels. Influence of the Evaluation of Immunology Learning

Introducción: Los estilos de aprendizaje según canales de percepción dominante del conocimiento de los estudiantes influyen en su aprendizaje. Su uso por los docentes puede favorecer o no a estudiantes con un canal específico. Objetivo: Describir la ubicación según los canales de percepción dominante del conocimiento de los estudiantes de medicina y la relación de estos con el resultado de las evaluaciones frecuentes en la asignatura Sangre y Sistema Inmune. Métodos: Se realizó una investigación en 234 estudiantes y 30 profesores de la carrera de medicina en los cursos 2020-2021 y 2022. Los estudiantes se clasificaron según los resultados de un cuestionario para identificar el predominio del canal de percepción (visuales-auditivos-kinestésicos) y a los profesores se les realizó una encuesta para determinar su percepción sobre el uso de estrategias de enseñanza diferenciales para cada canal. El procesamiento se realizó en programa SPSS 25, a través de números, porcentaje y prueba de ji al cuadrado. Resultados: Predominó el canal visual con el 48 por ciento. Existió asociación con el sexo con p = 0,0016; en varones prevaleció el canal auditivo y en hembras el visual. La relación entre los canales de percepción dominante y el rendimiento académico fue significativa con p = 0,000. Conclusiones: Prevaleció el canal de percepción dominante visual. La distribución de cada canal se asoció con el sexo y el rendimiento académico; así se lograron mejores resultados por los estudiantes con percepción dominante visual. Esto último estuvo relacionado con el predominio de acciones por parte de los docentes que potencian este canal de percepción(AU)

Introduction: Learning styles according to dominant perception channels of students' knowledge influence their learning. Their use by professors may or may not favor students with a specific channel. Objective: To describe the location according to the dominant knowledge perception channels of medical students and their relationship with the results of frequent evaluations in the subject Blood and Immune System. Methods: A research was conducted with 234 students and 30 professors of the Medicine major during the academic years 2020-2021 and 2022. The students were classified according to the results of a questionnaire to identify the perception channel predominance (visual-auditory-kinesthetic), while the professors were surveyed to determine their perception on the use of differential teaching strategies for each channel. Processing was performed in SPSS 25, using numbers, percentages and the chi-squared test. Results: The visual channel predominated, accounting for 48 percent. There was an association with sex (p=0.0016); the auditory channel prevailed among males, while the visual channel prevailed among females. The relationship between dominant perception channels and academic performance was significant (p=0.000). Conclusions: The visual dominant perception channel prevailed. The distribution of each channel was associated with sex and academic performance; thus, better results were achieved by students with visual dominant perception. The latter was related to the predominance of actions by professors that enhance this perception channel(AU)

Competencia en cuidado espiritual en enfermería: Revisión integrativa de literatura / Spiritual Care Competence in Nursing: Integrative Literature Review

Introducción: El cuidado espiritual puede considerarse un elemento central de la filosofía del cuidado holístico. Objetivo: Identificar investigaciones de intervención con perspectivas y estrategias educativas para el desarrollo de competencias en cuidado espiritual. Materiales y métodos: Revisión de la literatura en el período 2001-2021 de las bases de datos PubMed, ProQuest, Scopus, Lilacs y BVS (Biblioteca Virtual en Salud). Se siguieron las recomendaciones PRISMA y se basaron en parámetros definidos por Whittemore y Knafl para la identificación de problemas, búsqueda bibliográfica, evaluación y análisis de datos. Resultados: se encontraron 10 artículos de intervención publicados. Los entrenamientos relacionados con el desarrollo de habilidades para el cuidado espiritual fueron realizados en programas de formación superior del personal de enfermería. Las estrategias de instrucción son cursos específicos, sesiones cortas o programas a lo largo del plan de estudios. Las intervenciones muestran efectos sobre las habilidades y conocimientos. La espiritualidad individual de los estudiantes predice la capacidad de brindar atención espiritual. Conclusiones: Hay evidencia de estrategias para desarrollar la competencia de estudiantes y profesionales de enfermería en cuidado espiritual, aún son escasas las publicaciones sobre el tema, por lo que se necesitan nuevas y más rigurosas estrategias para desarrollar competencia en este enfoque de la disciplina de enfermería.

Introduction: Spiritual care can be considered a basic component of the philosophy of holistic care. Objective: Identify intervention studies with educational perspectives and strategies for developing spiritual care competencies in nurses and nursing students. Materials and methods: Integrative review of literature conducted in the period 2001-2021, in the databases PubMed, ProQuest, Scopus, LILACS, and VHL (Virtual Health Library). PRISMA statement guidelines were followed for the review, and it was based on Whittemore and Knafl's stages for integrative reviews: problem formulation, literature search, evaluation of data, data analysis, and presentation of results. Results: Ten published intervention articles were found. Education for the development of spiritual care competencies has been provided by educational programs and activities in undergraduate nursing programs and with professional nurses in practice. Instructional strategies include specific courses, short sessions, or programs throughout the curriculum. Interventions have an impact on skills and knowledge. Students' individual spirituality is a predictor of the competence to provide spiritual care. Conclusions: There is evidence of strategies to develop spiritual care competencies in nursing students and professionals, but publications on the subject are scarce. Therefore, implementing new and more rigorous strategies that allow the development of competencies for approaching spirituality in nursing is required.

Introdução: o cuidado espiritual pode ser considerado um componente básico da filosofia do cuidado holístico. Objetivo: determinar estudos de intervenção com perspectivas e estratégias educativas para o desenvolvimento da competência em cuidado espiritual em profissionais e estudantes de enfermagem. Materiais e Métodos: Revisão integrativa da literatura realizada no período de 2001-2021, nas bases de dados PubMed, ProQuest, Scopus, Lilacs e BVS (Biblioteca Virtual em Saúde). As recomendações do PRISMA foram seguidas e baseadas nos parâmetros estabelecidos por Whittemore e Knafl para identificação do problema, busca na literatura, avaliação dos dados, análise dos dados e apresentação dos resultados. Resultados: foram encontrados 10 artigos de intervenção publicados. A educação para o desenvolvimento de competências no cuidado espiritual tem sido realizada a partir de programas e atividades educativas, na graduação e nos profissionais de enfermagem durante sua prática. As estratégias de ensino são cursos específicos, sessões curtas ou programas ao longo do currículo. As intervenções mostram impactos nas habilidades e competências de conhecimento. A espiritualidade individual nos alunos é um preditor da capacidade de fornecer cuidados espirituais. Conclusões: Existem evidências de estratégias para desenvolver competências no cuidado espiritual em enfermagem em estudantes e profissionais, as publicações sobre o assunto são escassas, pelo que é necessária a implementação de estratégias inovadoras e mais rigorosas que permitam o desenvolvimento de competências para a abordagem em Enfermagem.

Cuidado espiritual en estudiantes de enfermería: estudio cualitativo / Spiritual Care in Nursing Students: Qualitative Study / Cuidado espiritual em estudantes de enfermagem: um estudo qualitativo

Introducción. La atención de la dimensión espiritual en pacientes y familias es fundamental como parte del papel activo de los profesionales de enfermería en la satisfacción de las necesidades espirituales de los pacientes. Objetivo. Comprender las actitudes frente al cuidado espiritual de los profesionales de enfermería en formación. Metodología. Estudio de abordaje cualitativo, con análisis de contenido, con población de 20 estudiantes de educación superior de Enfermería, con un muestreo por conveniencia. Se realizaron entrevistas semiestructuradas y dos grupos focales para indagar sobre el autoconocimiento espiritual y las concepciones del cuidado espiritual, tomando como referencia los conceptos teóricos propuestos por McSherry. El análisis de los datos inicialmente se hizo de forma inductiva, con ayuda del software Iramuteq. Resultados. La espiritualidad se considera una dimensión intrapersonal donde se reconoce la necesidad de explorar su propia espiritualidad para acercarse a la percepción espiritual del paciente. Aprender de las crisis para el desarrollo de la espiritualidad personal y encontrarse desde la naturaleza fueron parte de las categorías encontradas. Discusión. La concepción del cuidado espiritual para los estudiantes como dimensión intrapersonal, les permite distinguir entre la espiritualidad y la religiosidad. Este es un aspecto que se ha podido ver durante el desarrollo de las prácticas formativas, ya que se han encontrado personas muy religiosas, así como otras que no lo son. Conclusiones. Se hace referencia a la relación entre lo espiritual y lo corpóreo y aunque existe una diferencia entre religión y espiritualidad, los dos conceptos deben ser valorados a nivel personal.

Introduction. Attention to the spiritual dimension of patients and families is fundamental as part of the active role of nursing professionals in satisfying the spiritual needs of patients. Objective. To understand the attitudes towards spiritual care of nursing professionals in training. Methodology. Qualitative study with content analysis, with a population of 20 higher education Nursing students, with convenience sampling. Semi-structured interviews and two focus groups were held to explore spiritual self-knowledge and the conceptions of spiritual care, using the theoretical concepts proposed by McSherry as a reference. Data was initially analyzed inductively, with help from the Iramuteq software. Results. Spirituality is considered an intrapersonal dimension in which the need to explore one's own spirituality in recognized, in order to approach the spiritual perception of the patient. Learning about crises for the development of a personal spirituality and finding oneself through nature were part of the observed categories. Discussion. The conception of spiritual care as an intrapersonal dimension helps students differentiate between spirituality and religion. This aspecto has been observable during educational practice, since there were some very religious people and others who were not. Conclusions. Reference is made to the relationship between that which is spiritual and corporeal, and though there is a difference between spirituality and religion, both concepts must be assessed personally.

Introdução. A atenção à dimensão espiritual em pacientes e familiares é essencial como parte do papel ativo dos profissionais de enfermagem no atendimento às necessidades espirituais dos pacientes. Objetivo. Compreender as atitudes em relação aos cuidados espirituais dos profissionais de enfermagem em formação. Metodologia. Estudo de abordagem qualitativa, com análise de conteúdo, com uma população de 20 estudantes do ensino superior de Enfermagem, com amostragem por conveniência. Foram realizadas entrevistas semiestruturadas e dois grupos focais para indagar sobre autoconhecimento espiritual e concepções de cuidado espiritual, tomando como referência os conceitos teóricos propostos por McSherry. A análise dos dados foi feita inicialmente de forma indutiva, com o auxílio do software Iramuteq. Resultados. A espiritualidade é considerada uma dimensão intrapessoal onde se reconhece a necessidade de explorar a própria espiritualidade para se aproximar da percepção espiritual do paciente. Aprender com as crises para o desenvolvimento da espiritualidade pessoal e encontrar-se com a natureza foram algumas das categorias encontradas. Discussão. A concepção de cuidado espiritual para os alunos como uma dimensão intrapessoal, permite-lhes distinguir entre espiritualidade e religiosidade. Este é um aspecto que se tem visto ao longo do desenvolvimento das práticas formativas, uma vez que foram encontradas pessoas muito religiosas e outras não. Conclusões. É feita referência à relação entre o espiritual e o corpóreo e, embora haja uma diferença entre religião e espiritualidade, os dois conceitos devem ser valorizados a nível pessoal.

Competencia en cuidado espiritual en enfermería: Revisión integrativa de literatura / Spiritual Care Competence in Nursing: Integrative Literature Review

Introducción: El cuidado espiritual puede considerarse un elemento central de la filosofía del cuidado holístico. Objetivo: Identificar investigaciones de intervención con perspectivas y estrategias educativas para el desarrollo de competencias en cuidado espiritual. Materiales y métodos: Revisión de la literatura en el período 2001-2021 de las bases de datos PubMed, ProQuest, Scopus, Lilacs y BVS (Biblioteca Virtual en Salud). Se siguieron las recomendaciones PRISMA y se basaron en parámetros definidos por Whittemore y Knafl para la identificación de problemas, búsqueda bibliográfica, evaluación y análisis de datos. Resultados: se encontraron 10 artículos de intervención publicados. Los entrenamientos relacionados con el desarrollo de habilidades para el cuidado espiritual fueron realizados en programas de formación superior del personal de enfermería. Las estrategias de instrucción son cursos específicos, sesiones cortas o programas a lo largo del plan de estudios. Las intervenciones muestran efectos sobre las habilidades y conocimientos. La espiritualidad individual de los estudiantes predice la capacidad de brindar atención espiritual. Conclusiones: Hay evidencia de estrategias para desarrollar la competencia de estudiantes y profesionales de enfermería en cuidado espiritual, aún son escasas las publicaciones sobre el tema, por lo que se necesitan nuevas y más rigurosas estrategias para desarrollar competencia en este enfoque de la disciplina de enfermería.

Introduction: Spiritual care can be considered a basic component of the philosophy of holistic care. Objective: Identify intervention studies with educational perspectives and strategies for developing spiritual care competencies in nurses and nursing students. Materials and methods: Integrative review of literature conducted in the period 2001-2021, in the databases PubMed, ProQuest, Scopus, LILACS, and VHL (Virtual Health Library). PRISMA statement guidelines were followed for the review, and it was based on Whittemore and Knafl's stages for integrative reviews: problem formulation, literature search, evaluation of data, data analysis, and presentation of results. Results: Ten published intervention articles were found. Education for the development of spiritual care competencies has been provided by educational programs and activities in undergraduate nursing programs and with professional nurses in practice. Instructional strategies include specific courses, short sessions, or programs throughout the curriculum. Interventions have an impact on skills and knowledge. Students' individual spirituality is a predictor of the competence to provide spiritual care. Conclusions: There is evidence of strategies to develop spiritual care competencies in nursing students and professionals, but publications on the subject are scarce. Therefore, implementing new and more rigorous strategies that allow the development of competencies for approaching spirituality in nursing is required.

Introdução: o cuidado espiritual pode ser considerado um componente básico da filosofia do cuidado holístico. Objetivo: determinar estudos de intervenção com perspectivas e estratégias educativas para o desenvolvimento da competência em cuidado espiritual em profissionais e estudantes de enfermagem. Materiais e Métodos: Revisão integrativa da literatura realizada no período de 2001-2021, nas bases de dados PubMed, ProQuest, Scopus, Lilacs e BVS (Biblioteca Virtual em Saúde). As recomendações do PRISMA foram seguidas e baseadas nos parâmetros estabelecidos por Whittemore e Knafl para identificação do problema, busca na literatura, avaliação dos dados, análise dos dados e apresentação dos resultados. Resultados: foram encontrados 10 artigos de intervenção publicados. A educação para o desenvolvimento de competências no cuidado espiritual tem sido realizada a partir de programas e atividades educativas, na graduação e nos profissionais de enfermagem durante sua prática. As estratégias de ensino são cursos específicos, sessões curtas ou programas ao longo do currículo. As intervenções mostram impactos nas habilidades e competências de conhecimento. A espiritualidade individual nos alunos é um preditor da capacidade de fornecer cuidados espirituais. Conclusões: Existem evidências de estratégias para desenvolver competências no cuidado espiritual em enfermagem em estudantes e profissionais, as publicações sobre o assunto são escassas, pelo que é necessária a implementação de estratégias inovadoras e mais rigorosas que permitam o desenvolvimento de competências para a abordagem em Enfermagem.

La electrólisis percutánea intratisular: una revisión sistemática / Percutaneous intratissue electrolysis: a systematic review

La electrólisis percutánea intratisular es un procedimiento terapéutico tecnológico mínimamente invasivo para el tratamiento de lesiones en el sistema musculoesquelético mediante inflamación controlada y fagocitosis para recuperar el tejido afectado. Acerca de esta, se realizó un análisis de la producción científica publicada de 2014 a 2021. El estudio se realizó por medio de una revi-sión bibliográfica sistémica siguiendo la metodología PRISMA, que incluyó el uso de fuentes de información en las bases científicas: PubMed, SciencieDirect, EuropePMC, ResearchGate, Sage Journal, Thiem Connect y PHysiotherapy evidence database (PEdro). Previamente al procesa-miento de los datos, los documentos encontrados fueron sometidos diversos criterios de selec-ción. Los investigadores concluyeron que la electrólisis percutánea intratisular resulta un trata-miento efectivo para el tratamiento de tendinopatías crónicas, cuando se realiza combinado con un programa de ejercicios enfocado en la progresión de las cargas.

This work presents an analysis of the scientific production developed between 2014 and 2021 on percutaneous intratissue electrolysis. The objective is to analyze the bibliograpHy on the diffe-rent EPI interventions. The study was carried out through a systemic review following a methodological process according to PRISMA using various sources for the collection of information, such as: Pubmed, Scienciedirect, Europe PMC, Hindawi, Cochrane, Sage Journal, Thiem Connect, Pedro, Puerta Of the investigation. Selection and quality criteria were applied to these documents, with a subsequent analysis using qualitative techniques. In conclusion, intratissue percutaneous electrolysis turns out to be a favorable tool in the treatment of chronic tendinopathies as long as it is combined with an exercise program focused on load progression.

Gene Expression Profile of Stromal Factors in Cancer-Associated Fibroblasts from Prostate Cancer.

Recent investigations point at the stromal microenvironment to assess additional diagnostic information and provide new therapeutic targets in cancer. The aim of the study was to contribute to the characterization of the phenotype of cancer-associated fibroblasts (CAFs) in prostate cancer (PCa) compared with normal prostate-associated fibroblasts (NAFs) and fibroblasts from benign prostatic hyperplasia (BPH). Three patient populations were prospectively recruited: 23 patients with new localized PCa, 14 patients with advanced PCa treated with androgenic deprivation therapy (ADT), and 7 patients with BPH. Gene expression of 20 stroma-derived factors, including the androgen receptor (AR), chaperones (HSPA1A and HSF1), growth factors (FGF2, FGF7, FGF10, HGF, PDGFB, and TGFß), proteins implicated in invasion (MMP2, MMP9, and MMP11), inflammation (IL6, IL17RB, NFκB, and STAT3), and in-stroma/epithelium interaction (CDH11, CXCL12, CXCL14, and FAP), was evaluated. Localized PCa CAFs showed a significant higher expression of FGF7, IL6, MMP2, and MMP11 compared with NAFs or IL17RB compared with BPH fibroblasts, but significantly lower expression of FGF10 and IL17RB compared with NAFs or CXCL14 compared with BPH fibroblasts. In addition, CAFs from ADT-resistant PCa showed significantly higher MMP11 and NFκB but significant lower TGFß expression compared with CAFs from ADT-sensitive tumors. Our results contribute to defining the CAFs phenotypes associated to PCa progression, which may contribute to the diagnosis and design of alternative therapies in PCa.

Dry Needling in Physical Therapy Treatment of Chronic Neck Pain: Systematic Review.

Chronic Neck Pain (CNP) is one of the main causes of disability worldwide, and it is necessary to promote new strategies of therapeutic approach in the treatment of chronic pain. Dry needling (DN) is defined as an invasive physiotherapy technique used in the treatment of neuromusculoskeletal disorders. The purpose of this review was to assess the effectiveness of invasive techniques in treatment of CNP. The search focused on randomized clinical trials, and according to the selection criteria, eight studies were obtained. In conclusion, DN can be an effective treatment option for CNP, positive outcomes were achieved in the short-term and in the follow-up performed between three and six months, and this technique may offer better outcomes than a placebo intervention based on the application of simulated DN.

Effectiveness of Negative Pulsed-Pressure Myofascial Vacuum Therapy and Therapeutic Exercise in Chronic Non-Specific Low Back Pain: A Single-Blind Randomized Controlled Trial.

Non-specific low back pain is defined as pain located in the lumbar region; this condition is the most frequent musculoskeletal disorder. Negative pulsed-pressure myofascial vacuum therapy (vacuum treatment (VT)) devices mobilize tissue according to previously programmed parameters of force, time and frequency. The purpose of this study was to compare the effects of VT combined with core therapeutic exercise versus a physical therapy program (PTP) based only on core therapeutic exercise. Fifty participants with chronic non-specific low back pain were randomly assigned to two treatment groups, the VT group (n = 25) or the PTP group (n = 25). Pain, pressure-pain threshold, range of motion, functionality and quality of life were measured before treatment, at the end of treatment, and at one-month and three-month follow-ups. Both groups received 15 therapy sessions over 5 weeks. Statistically significant differences in favor of the VT group were shown in the results. In conclusion, the intervention based on myofascial vacuum therapy improved pain, mobility, pressure pain threshold, functionality and quality of life.

Differences in the use of telephone and video telemedicine visits during the COVID-19 pandemic.

OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic forced health systems to offer video and telephone visits as in-person visit alternatives. Although video visits offer some benefits compared with telephone visits, they require complex setup, which may disadvantage some patients due to the "digital divide." Our objective was to determine patient and neighborhood characteristics associated with visit modality. STUDY DESIGN: This was a cross-sectional study across 1652 primary care and specialty care practices of adult patients at an integrated health system from April 23 to June 1, 2020. METHODS: We used electronic health record and administrative data. Our primary outcome was visit modality (in-person, video, or telephone), which was captured using billing codes. We assessed predictors of using video vs telephone using multivariable logistic regression. We used hierarchical logistic regression to determine the contribution of patient-, physician-, and practice-level components of variance in the choice of video or telephone visits. RESULTS: We analyzed 231,596 visits by 162,102 patients. Sixty-five percent of the visits were virtual (31.7% telephone, 33.5% video). Patients who were older than 65 years (adjusted odds ratio [AOR], 0.41; 95% CI, 0.40-0.43), Black (AOR, 0.60; 95% CI, 0.57-0.63), Hispanic (AOR, 0.76; 95% CI, 0.73-0.80), Spanish-speaking (AOR, 0.57; 95% CI, 0.52-0.61), and from areas with low broadband access (AOR, 0.93; 95% CI, 0.88-0.98) were less likely to use video visits. Practices (38%) and clinicians (26%) drove more of the variation in video visit use than patients (9%). CONCLUSIONS: Telemedicine access differences may compound disparities in chronic disease and COVID-19 outcomes. Institutions should monitor video visit use across demographics and equip patients, clinicians, and practices to promote telemedicine equity.

Prevención del linfedema posquirúrgico en cáncer de mama mediante rehabilitación fisioterapéutica: estudio comparativo entre drenaje linfático manual y kinesiotape / Prevention of postsurgical lymphedema in breast cancer through physiotherapeutic reha- bilitation: a comparative study between manual lymphatic drainage and kinesiotape

Se realizó un estudio con diseño cuantitativo, de tipo observacional descriptivo; cuya población de estudio estuvo constituida por 142 pacientes de sexo femenino, diagnosticadas con cáncer de mama en la Unidad Oncológica Solca-Chimborazo, durante el período 2014-2019; con el objeti - vo de describir el tratamiento fisioterapéutico en ese contexto de investigación. Los datos fueron recolectados a partir de las respectivas historias clínicas. A partir de 2015, se observó un predo- minio de pacientes adultos con edades comprendidas entre 36 y 65 años. De las 142 pacientes que conformaron la población estudiada, solo 5 desarrollaron linfedema posquirúrgico. La mayoría de las pacientes incluidas en el estudio fueron intervenidas quirúrgicamente (65); 59 de las cuales recibieron tratamiento de drenaje linfático manual. Entre la población elegida en la Unidad Oncológica de Solca-Chimborazo se evidenció que la aplicación de terapia de rehabili - tación mediante drenaje linfático manual posquirúrgico reduce la posibilidad de aparición de linfedema a largo plazo.

This research aimed to describe the physiotherapeutic treatment in this research context. A study was carried out with a quantitative design, of a descriptive observational type. The study popula- tion consisted of 142 female patients, diagnosed with breast cancer at the Solca-Chimborazo Oncology Unit, during the period 2014-2019. The data were collected from the respective medi- cal records. Since 2015, a predominance of adult patients aged between 36 and 65 years was observed. From the 142 patients that made up the study population, only 5 developed postsurgi- cal lymphedema. Most of the patients included in the study underwent surgery (65); 59 received manual lymphatic drainage treatment. Among the population chosen in the Solca-Chimborazo Oncology Unit, it was evidenced that the application of rehabilitation therapy through postope- rative manual lymphatic drainage reduces the possibility of long-term lymphedema develop - ment.

Percutaneous Electrolysis in the Treatment of Lateral Epicondylalgia: A Single-Blind Randomized Controlled Trial.

Few studies have considered the effects of percutaneous electrolysis (PE) in the treatment of lateral epicondylalgia (LE). For this reason, the objective of this study was to compare the effects of PE with an evidence-based approach-trigger point dry needling (TDN)-in patients with LE. A randomized controlled trial was conducted in which 32 participants with LE were randomly assigned to two treatment groups, the PE group (n = 16) and the TDN group (n = 16). Both groups received four therapy sessions and an eccentric exercise program to be performed daily. The numerical pain rating scale (NPRS), pressure pain thresholds (PPT), quality of life, and range of motion were measured before treatment, at the end of treatment, and at one- and three-month follow-ups. Significant between-group mean differences were found after treatment for NPRS (p < 0.001) and flexion movement (p = 0.006). At one-month follow-up, significant mean differences between groups were found for NPRS (p < 0.001), PPT (p = 0.021), and flexion (p = 0.036). At three-months follow-up, significant mean differences between groups were found for NPRS (p < 0.001), PPT (p = 0.004), and flexion (p = 0.003). This study provides evidence that PE could be more effective than TDN for short- and medium-term improvement of pain and PPTs in LE when added to an eccentric exercise program.

Effectiveness of Percutaneous Electrolysis in Supraspinatus Tendinopathy: A Single-Blinded Randomized Controlled Trial.

Supraspinatus tendinopathy is one of the most common causes of shoulder pain. Many studies support conservative treatments such as exercise, trigger point dry needling or corticosteroid injections. Otherwise, a minimally invasive approach with percutaneous electrolysis (PE) has also been used successfully in shoulder pain, although evidence about its long-term effects is scarce. The aim of this trial was to determine the effects of PE on supraspinatus tendinopathy compared with trigger point dry needling (TDN). Thirty-six patients with supraspinatus tendinopathy were randomly assigned to either a PE group (n = 18) or a TDN group (n = 18). Both groups also performed eccentric exercises. The main outcome to be measured was the Numerical Pain Rating Scale (NPRS), but the shoulder range of motion (ROM) and trigger point pressure pain threshold (PPT) were also considered. A one-year follow-up was conducted. Significant differences favoring the PE group were found regarding pain at one-year follow-up (p = 0.002). The improvement achieved in the PE group was greater in the NPRS (p < 0.001), proximal PPT, middle PPT, distal PPT (all p < 0.001) and ranges of movement. PE seems to be more effective than TDN in relieving pain and improving ROM and PPT supraspinatus values in patients with supraspinatus tendinopathy, both right after treatment and at one-year follow-up.

Characterization of cannonball jellyfish (Stomolophus sp. 2) blue protein: a pH-stable pigment.

Pigments are present in a broad variety of terrestrial and aquatic organisms. The cannonball jellyfish (Stomolophus sp. 2) is an important fishery resource in the northwest of Mexico and is processed to be traded and consumed as seafood. During the process, water with a soluble blue pigment and other compounds are discarded to the environment. In this work, we present some properties of the blue pigment from Stomolophus sp.2 (S2bp), to decide if it could be considered as a potential value-added waste and avoid the blue proteinaceous pigment wastewater. S2bp was purified to homogeneity and had a molecular mass of 28.0 kDa; this protein exhibited a ʎmax at 650 nm, contained Zn2+ and Cu2+ metal ions, and was stable from 10 to 50 °C and in a pH range of 3.0 to 13.0 for 1 h. It had halotolerant characteristics maintaining the blue coloration in a broad range of ionic strength (0-4 M NaCl) and showed changes in ʎmax with chaotropic salts. In addition, S2bp was stable in the presence of organic acids and EDTA and in zwitterionic, anionic, and nonionic detergents at critical micellar concentration. However, oxidant reagents like NaClO and H2O2 decrease the coloration. These results show that the jellyfish pigment is a stable protein which makes it an alternative pigment for the food industry.

Dose-response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current.

Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primary F3II tumor growing in male and female BALB/c/Cenp mice under electrochemical treatment. Different amounts of electric charge (6, 9, and 18 C) were used. Two electrodes were inserted into the base, perpendicular to the tumor's long axis, keeping about 1 cm distance between them. Results have shown that the F3II tumor is highly sensitive to direct current. The overall effectiveness (complete response + partial response) of this physical agent was ≥75.0% and observed in 59.3% (16/27) of treated F3II tumors. Complete remission of treated tumors was observed in 22.2% (6/27). An unexpected result was the death of 11 direct current-treated animals (eight females and three males). It is concluded that direct current may be addressed to significantly affect highly aggressive and metastatic primary tumor growth kinetics, including the tumor complete response. Bioelectromagnetics. 39:460-475, 2018. © 2018 Wiley Periodicals, Inc.

Psychological Effects of Group Hypnotherapy on Breast Cancer Patients During Chemotherapy.

The purpose of this study was to evaluate the effect of group hypnotherapy on anxiety, depression, stress, self-esteem, optimism, and social support during chemotherapy, in patients with breast cancer, compared with a control group with standard medical care. Hypnotherapy consisted of 24 sessions that included suggestions to encourage relaxation, self-esteem, the resolution of past traumatic events, physical healing, and optimism. Results show that the hypnotherapy group significantly decreased anxiety, distress, increased self-esteem, and optimism in the first 12 sessions. However, at the end of the 24 sessions, only self-esteem and optimism remained significant compared with the control group. The convenience of using hypnotherapy to encourage optimism and self-esteem in patients with breast cancer during chemotherapy treatment is discussed given its protective effect on health.

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glutamate and may use it through oxidative glutamate dehydrogenase (GDH) activity. Here, we investigated the significance of glutamate as energy substrate for the brain. Upon glutamate exposure, astrocytes generated ATP in a GDH-dependent way. The observed lack of glutamate oxidation in brain-specific GDH null CnsGlud1(-/-) mice resulted in a central energy-deprivation state with increased ADP/ATP ratios and phospho-AMPK in the hypothalamus. This induced changes in the autonomous nervous system balance, with increased sympathetic activity promoting hepatic glucose production and mobilization of substrates reshaping peripheral energy stores. Our data reveal the importance of glutamate as necessary energy substrate for the brain and the role of central GDH in the regulation of whole-body energy homeostasis.

La rehabilitación física de mujeres mastectomizadas desde la perspectiva de ciencia, tecnología y sociedad / The physical rehabilitation of mastectomized women from the perspective of science, technology and society

Introducción: El cáncer de mama en Cuba constituye una de las primeras causas de muerte en las féminas, por lo que se trabaja incansablemente para encontrar una respuesta a esta problemática de salud, con este fin se elaboran instrumentos que sirvan de orientación en la aplicación de intervenciones de prevención, detección precoz y tratamiento. Se realizó un estudio con el objetivo de reflexionar desde la perspectiva de ciencia, tecnología y sociedad acerca de la rehabilitación física de mujeres con cáncer de mama mastectomizadas. Desarrollo: Existe un conocimiento ético política del trabajo científico que incluye la clara concepción de que el mismo se realiza para satisfacer las necesidades del desarrollo social y la satisfacción de los ciudadanos al tener en cuenta que no existen paradigmas que frenen el desarrollo científico tecnológico para el bien y la supervivencia humana. Ese conocimiento es compartido por los actores involucrados en los procesos científicos tecnológicos y de innovación; los que tienen sus raíces en las transformaciones sociales que el país ha vivido y la ideología revolucionaria que lo ha conducido. Conclusiones: La incorporación de la Medicina Bioenergética y Naturista con su método inocuo y sin efectos colaterales de digitopresión para la rehabilitación física del miembro comprometido, permite brindar a las pacientes un mejor estado de salud, al incidir en la sobrevida, al mismo tiempo se aprecia el cáncer como una enfermedad crónica no transmisible y no como enfermedad terminal. Con el presente estudio se puede evaluar un gran impacto económico, social y científico (AU)

Introduction: The breast cancer in Cuba is one of the leading causes of death in females, so it is working tirelessly searching for an answer to this problem of health, to this end are elaborated instruments that serve as guidance in the implementation of interventions for prevention, early detection and treatment. A study with the aim of reflecting the perspective of science, technology and society about the physical rehabilitation of women with breast cancer mastectomy was carried out. Development: An ethical and political knowledge exists of scientific work that includes clear conception that it is done to meet the needs of social development and the satisfaction of citizens to keep in mind that there are no paradigms that restrain the technological scientific development for the good and human survival. That knowledge is shared by those people involved in the scientific technological and innovation process; those who have their roots in the social transformations that the country has experienced and the revolutionary ideology that has led it. Conclusions: The incorporation of the Bioenergetic Medicine and naturist with its innocuous method and without side effects of digitopressure for the physical rehabilitation of the committed member, it allows to give patients a better state of health, influencing the survival, at the same time it can see cancer as a chronic non-transmissible and not terminal disease. A great economic, social and scientific impact can be evaluated with this study (AU)