[Anterior rhinomanometry as a diagnostic test in occupational allergy caused by Liliaceae]. / Rinomanometría anterior como test diagnóstico en alergia ocupacional por liliáceas.

UNLABELLED: The Liliacea family has been implicated as a cause of occupational rhinoconjunctivitis and bronchial asthma. We report a patient who presented symptoms when he manipulated spices including garlic and onion dusts. Nasal challenge test with active anterior rhinomanometry was used for the diagnosis. MATERIAL AND METHODS: Skin-prick tests with common inhalants, commercial spices, fresh Liliaceae and powdered spices diluted in saline solution (10 mg/ml) were performed. Immunoblot and specific IgE (CAP-Pharmacia) were determined. Control peak expiratory flow was monitored during a period at work in an area where spices were manipulated and in an area where they were transported. Nasal challenge test with garlic and onion powder was performed. The resulting nasal obstruction was measured as nasal airway resistance and was determined by rhinomanometry. RESULTS: Skin-prick tests were positive for onion, garlic powder and fresh Liliacea. Specific IgE were positive for garlic and onion. IgE immunoblotting showed very strong bands at 14 and 40 kD with garlic extract. Nasal challenge showed an increase in inspiratory nasal resistance which was higher than 100 % of the basal value for both onion extract and garlic.

Rinomanometría anterior como test diagnóstico en alergia ocupacional por liliáceas / No disponible

La familia de las liliáceas ha sido implicada en el desarrollo de rinoconjuntivitis y asma bronquial ocupacional. Presentamos un paciente con síntomas cuando manipulaba especias, incluyendo ajo y cebolla en polvo. Material y métodos: Se realizan test cutáneos con inhalantes, especias comerciales, liliáceas en fresco y con extractos de polvo de especias. Se determinó IgE especifica (CAP-Pharmacía) y se realizó Immunoblotting con ajo.Se llevo a cabo control de pico flujo (PEF) en la zona de manipulación de especias y en la zona de transporte del producto envasado. Se realizó test de provocación nasal con el ajo y la cebolla y se midió la obstrucción nasal mediante rinomanometría anterior activa (RAA). Resultados: Los test cutáneos fueron positivos con el polvo de ajo, cebolla, y con las liliáceas en fresco. La IgE específica fue positiva para ajo y cebolla. El immunoblotting mostró dos bandas de fuerte intensidad correspondiente a 14 y 40 KD con el extracto de ajo. Se objetivó un aumento de la resistencia nasal superior al 100 per cent con ambos extractos (AU)

The Liliacea family has been implicated as a cause of occupational rhinoconjunctivities and bronchial asthma. We report a patient who presented symptoms when he manipulated spices including garlic and onion dusts. Nasal challenge test with active anterior rhinomanometry was used for the diagnosis. Material and methods: Skin-prick tests with common inhalants, commercial spices, fresh Liliaceae and powdered spices diluted in saline solution (10 mg/ml) were performed. Immunoblot and specific IgE (CAP-Pharmacia) were determined. Control peak expiratory flow was monitored during a period at work in an area where spices were manipulated and in an area where they were transported. Nasal challenge test with garlic and onion powder was performed. The resulting nasal obstruction was measured as nasal airway resistance and was determined by rhinomanometry. Results: Skin-prick tests were positive for onion, garlic powder and fresh Liliacea. Specific IgE were positive for garlic and onion. IgE immunoblotting showed very strong bands at 14 and 40 kD with garlic extract. Nasal challenge showed an increase in inspiratory nasal resistance which was higher than 100 % of the basal value for both onion extract and garlic (AU)