[A comparative evaluation of modern antibacterial preparations in the treatment of a severe degree of periodontitis at a stage of exacerbation]. / Sravnitel'naia otsenka sovremennykh antibakterial'nykh preparatov pri lechenii parodontita tiazheloi stepeni v stadii obostreniia.

Sensitivities of peptostreptococci, streptococci, Actinomyces, bacteroid, and fusobacterial strains pathogenic for the periodontium to wide-spectrum penicillines, cephalosporines, lincomycin, macrolides, metronidasole, and nitasole are compared. New macrolide antibiotics rulide. Macropene, gramicidin C, levomycetin, and rifampicin are highly effective. Some narrow-spectrum drugs, e.g. augmentin, cephalexin, and vancomycin (towards actinomycetes) were highly effective, too.

[The choice of antibacterial preparations for the combined treatment of periodontitis in the exacerbation stage]. / Vybor antibakterial'nykh preparatov dlia kompleksnogo lecheniia parodontita v stadii obostreniia.

Antibiotic sensitivities of peptostreptococci, streptococci, Actinomyces, bacteroid, and fusobacterial strains pathogenic for the periodontium are analyzed. The sensitivities of these bacteria to broad-spectrum penicillins, cephalosporines, lincomycin, and macrolides, and to metronidasole and nitasole are assessed. New macrolide drugs macropen and rulide and gramicidine C, levomycetine, and rifampicin are highly active towards the above microflora. Microbiological indications for oral and local use of these antibiotics are validated. Some narrow-spectrum antibiotics, such as augmentine, cephalexin, and vancomicin are highly active, too; the latter drug is specifically active towards Actinomyces.

[Antibacterial therapy in the combined treatment of periodontitis]. / Antibakterial'naia terapiia v kompleksnom lechenii parodontita.

The sensitivities of clinical strains of obligate anaerobic bacteria, isolated from the periodontal pouches of patients with generalized periodontitis, to antibiotics, quinolone drugs, and metronidasole were studied. The minimal suppressing concentration (MSC90) of ciprofloxacin, norfloxacin, and antibiotics gramicidin C, eritromicin, lincomycin, levomicetin, and trichopol for sensitive strains of Porphyromonas, peptostreptococci, and fusobacteria ranged from 5 to 10 mg/ml. Among the bacteria and actinomyces studied the highest percentage of resistant strains was noted for abactal and tarivid, and the minimal for gramicidin C and eritromicin. Actinomyces were little sensitive to quinolone derivatives.