RESUMO
Aeroallergen-induced infiltration of eosinophils in the bronchoalveolar lavage fluid (BALF) in guinea pigs was used as a marker of bronchial inflammation. Drugs were administered orally 4 h after aeroallergen challenge. Allergic bronchial eosinophilia in guinea pigs was inhibited by orally administered dexamethasone and methylprednisolone. Terfenadine (a newer H1-receptor antagonist), theophylline (a nonspecific phosphodiesterase inhibitor), and salbutamol (a beta 2-agonist) did not influence allergic eosinophilic infiltration. Many of these agents, administered prophylactically, have been reported to suppress allergic eosinophilic infiltration in the BALF of guinea pigs. Methylprednisolone, a steroid, inhibits allergic bronchial eosinophilia regardless of the time of administration; that is, 2 h before or 4 h after aeroallergen challenge. The therapeutic approach used in this study may facilitate drug discovery for bronchial inflammation/asthma.
Assuntos
Anti-Inflamatórios/uso terapêutico , Asma/tratamento farmacológico , Hiper-Reatividade Brônquica/tratamento farmacológico , Eosinofilia/tratamento farmacológico , Albuterol/uso terapêutico , Alérgenos/administração & dosagem , Animais , Anti-Inflamatórios/administração & dosagem , Asma/patologia , Hiper-Reatividade Brônquica/patologia , Líquido da Lavagem Broncoalveolar/citologia , Dexametasona/uso terapêutico , Modelos Animais de Doenças , Esquema de Medicação , Avaliação Pré-Clínica de Medicamentos , Eosinofilia/patologia , Eosinófilos/efeitos dos fármacos , Cobaias , Masculino , Metilprednisolona/uso terapêutico , Ovalbumina/imunologia , Terfenadina/uso terapêutico , Teofilina/uso terapêuticoRESUMO
The beneficial effects of transcutaneous nerve stimulation (TNS) and cryoanalgesia for post-thoracotomy pain were compared against each other and against a control group through pulmonary function testing in the immediate and delayed postoperative period. Patients receiving cryoanalgesia did not perform well in the first 24 hours after operation. However, by the fifth postoperative day, they did as well as or even better than the TNS patients. Both cryoanalgesia and TNS were significantly effective in the management of postoperative pain as compared with controls.
Assuntos
Terapia por Estimulação Elétrica , Hipotermia Induzida , Dor/prevenção & controle , Testes de Função Respiratória , Cirurgia Torácica , Estimulação Elétrica Nervosa Transcutânea , Humanos , Período Pós-OperatórioRESUMO
A prospective randomized double-blind study was undertaken to evaluate the efficacy of transcutaneous nerve stimulation (TNS) in relief of acute post-thoracotomy pain by comparing postoperative narcotic requirements in 22 patients having TNS and in 22 patients having sham electrical stimulation. All patients in both groups had intrathoracic malignancies. When TNS was used, 22.7% of the patients required no narcotics in the first 24 hr postoperatively. All patients having sham stimulation required postoperative narcotics.