Assuntos
Suplementos Nutricionais , Magnésio/administração & dosagem , Pseudoxantoma Elástico/diagnóstico , Pseudoxantoma Elástico/tratamento farmacológico , Administração Oral , Relação Dose-Resposta a Droga , Método Duplo-Cego , Esquema de Medicação , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Valores de Referência , Medição de Risco , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
BACKGROUND: Chronic hand and foot eczema (CHFE), a prevalent debilitating disorder affecting approximately 15% of the population, presents a socioeconomic and psychosocial burden for patients and often follows a chronic course, refractory to conventional therapies. Thus, a large need exists for more effective therapeutics; the excimer laser (308 nm) is effective for some inflammatory skin diseases, but its efficacy has not been evaluated for CHFE. METHODS: The study is a retrospective chart review conducted on 30 patients with recalcitrant CHFE (19 with hand involvement, four with foot involvement, and seven with both) treated twice weekly with excimer laser (308 nm) single wavelength ultraviolet (UV)B radiation between January 2013 and December 2014. RESULTS: Improvements in clinical scores included a 69% reduction in average physician's global assessment (PGA) scores (from 2.77 at baseline to 0.87 after treatment, P < 0.0001) with a parallel reduction in average modified total lesion/symptom scores of 70% (from 10.2 to 3.1, P < 0.0001). Only mild sunburn-like reactions were observed. CONCLUSION: This report evaluates excimer laser for patients with refractory CHFE and shows excellent and sustained efficacy for this treatment. Compared to other UV therapies, excimer laser offers lower cumulative doses of UV radiation by targeting specific areas. This effective treatment should be considered alone or in combination with other established or newer therapies.
Assuntos
Eczema/radioterapia , Dermatoses do Pé/radioterapia , Dermatoses da Mão/radioterapia , Lasers de Excimer , Terapia com Luz de Baixa Intensidade/métodos , Adolescente , Adulto , Idoso , Criança , Doença Crônica , Estudos de Coortes , Eczema/diagnóstico , Feminino , Seguimentos , Dermatoses do Pé/diagnóstico , Dermatoses da Mão/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Satisfação do Paciente/estatística & dados numéricos , Estudos Retrospectivos , Índice de Gravidade de Doença , Estatísticas não Paramétricas , Resultado do Tratamento , Adulto JovemRESUMO
This article reports the results of speech error elicitation experiments investigating the role of two consonant co-occurrence restrictions in the productive grammar of speakers of two Ethiopian Semitic languages, Amharic and Chaha. Higher error rates were found with consonant combinations that violated co-occurrence constraints than with those that had only a high degree of shared phonological similarity or low frequency of co-occurrence. Sequences that violated two constraints had the highest error rates. The results indicate that violations of consonant co-occurrence restrictions significantly increase error rates in the productions of native speakers, thereby supporting the psychological reality of the constraints.