[Comparative study of the chemotherapeutic effectiveness of mecillinam, ampicillin and their combination in coli bacillary pyelonephritis in rats]. / Sravnitel'noe izuchenie khimioterapevticheskoi éffektivnosti metsillinama, ampitsillina i ikh kombinatsii pri kolibatsilliarnom pielonefrite u krys.

The chemotherapeutic effect of mecillinam and ampicillin was studied comparatively on rats with hematogenic obturation colibacillary pyelonephritis. The antibiotics were administered intragastrically in a dose of 100 mg/kg for 7 days. The treatment was started 24 hours after infection. When the drugs were used in combination their doses were twice as lower. When used alone mecillinam and ampicillin had a significant effect which was practically the same. A marked increase in the therapeutic effect was observed with the use of the antibiotics in combination: sterilization of the tissues of the affected kidney and prevention of development of macroscopic lesions in it in all the animals.

[Chemotherapeutic effectiveness of gentamycin, tobramycin and sisomycin in Pseudomonas aeruginosa pyelonephritis in rats compared with dioxidine]. / Izuchenie khimioterapevticheskoi éffektivnosti gentamitsina, tobramitsina i sizomitsina pri sinegnoinom pielonefrite u krys v sravnenii s dioksidinom.

The chemotherapeutic efficacy of gentamicin, tobramycin, sisomicin and dioxydin was studied and compared in rats with hematogenic obturation P. aeruginosa pyelonephritis. The drugs were injected intramuscularly in doses of 5, 8, 8 and 50 mg/kg, respectively for 7 days a day after infection. It was shown that on prolongation of the period of the treatment estimation from 24 hours to 7 days after discontinuation of the drug use a significant decrease was observed in the therapeutic efficacy of dioxydin, gentamicin and especially tobramycin. As for sisomicin, the decrease was insignificant. Dioxydin and gentamicin had a similar therapeutic effect at the early and late periods of their estimation after discontinuation of the treatment. They were inferior to tobramycin with respect to the early results and superior to it with respect to the late results. The chemotherapeutic efficacy of sisomycin in both the cases was higher than that of tobramycin, gentamicin and dioxydin.

[Dioxidine and carbenicillin in Pseudomonas aeruginosa pyelonephritis in rats]. / Dioksidin i karbenitsillin pri sinegnoinom pielonefrite u krys.

Dioxidine (50 mg/kg a day) and carbenicillin (500 mg/kg a day) administered to rats with Ps. aeruginosa hematogenic pyelonephritis for 7 days brought about high therapeutic effect accompanied by bacteremia elimination, noticeable reduction of bacteriuria and dissemination of renal tissue, by improvement of the histological structure of the kidneys as compared with untreated animals. Complete recovery of all the animals (sterilization of the urine and tissue of both the kidneys), and abolition of pyelonephritis signs in the histological structure of the kidneys are attained as a result of combined use of dioxidine and carbenicillin in doses 25 and 250 mg/kg, respectively.

[Bacteriological and pathomorphological control of the effectiveness of the therapy of experimental pyocyanic burn infection]. / Bakteriologicheskii i patomorfologicheskii kontrol' éffektivnosti terapii éksperimental'noi sinegnoinoi ozhogovoi infektsii.

Bacteriological and pathomorphological characteristics of experimental pyocyanic burn infection in noninbred albino mice are presented. The model was used for comparative investigation of the chemotherapeutic efficacy of quinoxidin, dioxidin, carbenicillin and gentamicin. The chemotherapeutic efficacy of quinoxidin and dioxidin was shown to be higher than that of carbenicillin and gentamicin with respect to both the bacteriological criteria and the pathomorphological indices. Carbenicillin was inferior to gentamicin in the results of the bacteriological investigation and superior to it with respect to the data of the pathomorphological study. Thus, quinoxidin, dioxidin and to a less extent carbenicillin prevented the development of the purulent inflammatory foci in the internal organs, whereas the use of gentamicin resulted in a slower rate of the inflammatory process organization in the kidneys of the experimental animals.

[Comparative experimental study of cyclacillin and ampicillin]. / Sravnitel'noe izuchenie tsiklatsillina i ampitsillina v éksperimente.

Cyclacillin was compared with ampicillin by its bacteriostatic efficiency in vitro, chemotherapeutic efficiency in experimental infections of mice and rats and pharmacokinetic characteristics. It was found that cyclacillin was not superior to ampicillin by its antibacterial action. By a number of characteristics it was even significantly inferior. The pharmacokinetic advantages of cyclacillin were not considered significant.

[Dioxidine in experimental pyocyanic pyelonephritis in rats]. / Dioksidin pri éksperimental'nom sinegnoinom pielonefrite u krys.

A model of obturation hematogenous pyelonephritis was reproduced in rats by infecting them with Pseudomonas aeruginosa. On the model subject to study was chemotherapeutic activity of dioxidine (50--100 mg/kg per day) as compared to gentamycin (5 mg/kg per day). The drugs were administered intramuscularly for 7 days, starting 24 hours after inoculation of the animals. The action of both dioxidine and gentamycin on lethality, bacteriura, the mass of the kidneys and macroscopic changes in them was approximately the same, but dioxidine extered a greater influence on the seeding rate of the causative agent coming from the kidneys. Both drugs fail to bring about complete recovery of the animals.

[Comparative study of the semisynthetic penicillins in the experimental therapy of pneumococcal and streptococcal infections in mice]. / Sravnitel'noe izuchenie polusinteticheskikh penitsillinov pri éksperimental'noi terapii pnevmokokkovoi i streptokokkovoi infektsii u myshei

Penicillins were studied comparatively on mice with infections caused by pneumococci and streptococci. It was shown that klomethacillin was superior by its chemotherapeutic effect to other penicillins in treatment of pneumococcal septicemia when used subcutaneously or intragastrically. Ampicillin was superior in treatment of streptococcal infection.

[Experimental therapy of burn infection caused by pyocyanic bacilli]. / Eksperimental'naia terapiia ozhogovoi infektsii, vyzvannoi sinegnoinoi palochkoi

The chemotherapeutic effect of di-N-quinoxaline oxide derivatives--quinoxidine and diaxidine, as contrasted to that of carbenicillin and hentamycin with their 3- and 10-day application, was studied on a model of a burn in mice infected with Pseudomonas eruginosa. The results achieved by the quinoxidine and dioxidine medication proved much better than those obtained by the use of carbenicillin and hentamycin.