1.
Int J Mol Sci
; 15(11): 20403-12, 2014 Nov 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25383681
RESUMO
We report the discovery of aurora kinase inhibitor using the fragment-based virtual screening by multi-docking strategy. Among a number of fragments collected from eMololecules, we found four fragment molecules showing potent activity (>50% at 100 µM) against aurora kinase. Based on the explored fragment scaffold, we selected two compounds in our synthesized library and validated the biological activity against Aurora kinase.