[Experimental and clinical study of preparation Iridol action on the central nevros system].

In experiment on adult rats male the anxiolitic action of new plant origin drug Iridol, enriched with compounds iridoids, is shown. This effect of Iridol was approximately the same as by diazepam. In patients with arterial hypertension I - II degree, accompanied by psychoemotional disturbances, the use of Iridol in complex treatment increases efficacy of therapy.

[Biologically active substances in garlic (Allium sativum L.) and their application in nutrition for humans]. / Biologicheski aktivnye veshchestva chesnoka (Allium Sativum L.) i ikh ispol'zovanie v pitanii cheloveka.

Reviewed above is chemical composition of garlic and its biological Hypolipidemic, antioxidative, antibacterial and antitumorogenic properties of preparations were elucidated in experimental, clinical and epidemiological observations. It has been concluded that garlic are useful for prevention and combined treatment of most chronical diseases.

[Features of the effect of saturated and unsaturated fatty acids on lipid metabolism, lipoproteins, and development of ischemic heart disease]. / Osobennosti vliianiia nasyshchennykh i nenasyshchennykh zhirnykh kislot na obmen lipidov, lipoproteindov i razvitie ishemicheskoi bolezni serdtsa.

The effect of saturated, mono- and polyunsaturated fatty acid on lipid, lipoprotein metabolism and ischaemic heart disease is reviewed. Optimal effect on lipid and lipoprotein metabolism and prevention of ischemic heart disease exert only physiologically correlated amount of saturated and unsaturated fatty acid. Especially negative metabolic action is noted by use of heated oils contained polyunsaturated fatty acids.

[The efficacy of substances with antihypoxic action in experimental hyperlipidemia]. / Effektivnost' veshchestv antigipoksicheskogo deistviia pri éksperimental'noi giperlipidemii.

Experiments on rats, guinea pigs and rabbits with hyperlipidemia induced by high-cholesterol diet have revealed that the specific antihypoxic drug oliphen has hypolipidemic effect which is least pronounced in oral GABA. Oliphen causes a significant increase in alpha-cholesterol (antiatherogenic lipoprotein cholesterol) decreased by hyperlipidemia. It is suggested that oliphen improves hepatic receptor-dependent uptake and atherogenic lipoprotein degradation.

[The hypolipidemic action of water-soluble enterosorbents of cholesterol and bile acids in an experiment]. / Gipolipidemicheskoe deistvie vodorastvorimykh énterosorbentov kholesterina i zhelchnykh kislot v éksperimente.

Experiments on rats, guinea pigs and rabbits with experimental dyslipoproteinemia have revealed that the new water-soluble high-molecular weight polymers containing digitonin (ED) or a quaternary nitrogen atom (EA) have a more marked hypolipidemic action than cholestyramine and normalize lipoprotein metabolism. The digitonin-containing enterosorbent has been shown to decrease the absorption of 4-14C-cholesterol, while the nitrogen-containing enterosorbent diminishes the absorption of 3H-cholic acid.

[The hypolipidemic activity of natural substances]. / Gipolipidemicheskaia aktivnost' veshchestv prirodnogo proiskhozhdeniia.

Experiments on guinea pigs and rats have revealed that thiazole derivatives of isoflavone has a beneficial effects on disturbed lipid and lipoprotein metabolism. New phospholipid complexes enriched with vitamins have been demonstrated to produce a hypolipidemic effect. Sulfated chitosans decrease lipid infiltration of the liver and elevate serum high density lipoprotein levels in rats.

[Changes in the blood serum lipids and lipoproteins of rats in ovariectomy and to the administration of the methyl ester of 6-hydroxy-D-homo-8-isoestrone]. / Izmeneniia lipidov i lipoproteinov syvorotki krovi krys pri ovariéktomii i vvedenii metilovogo éfira 6-oksi-D-gomo-8-izoéstrona.

Ovariectomy of rats resulted in biphasic increase of the blood plasma cholesterol (on days 42-54, 70), the alteration of lipoprotein spectrum. The administration to ovariectomized rats of methyl ether 6-oxy-D-homo-8-isoestrone in a dose of 0.01 mg/kg brought about lowering of serum cholesterol and normalization of lipoproteins spectrum. The above trends were not observed after introduction of 0.01 mg/kg estradiol.

[The experimental effect of amino acids on lipid metabolic indices]. / Vliianie nekotorykh aminokislot na pokazateli lipidnogo obmena v éksperimente.

The action of amino acids prevalent in soy bean proteins, as compared to casein, on lipid metabolism was studied. Administration of aspartate to experimental hyperlipidemic rats produced a pronounced hypocholesterolemic effect and led to an increased alpha-cholesterol level. Addition of glycine, arginine and cysteine to aspartate raised the hypocholesterolemic effect. However, under these conditions the content of triglycerides in the liver as well as their levels in the blood serum of intact experimental animals were increased.

[The hypolipidemic and antiatherosclerotic action of absorbable and nonabsorbable substances in the intestines]. / Gipolipidemicheskoe i antiateroskleroticheskoe deistvie veshchestv, vsasyvaiushchikhsia i ne vsasyvaiushchikhsia v kishechnike.

Hypolipidemic effect of the polyphenol compound triophen possessing antihypoxic activity was demonstrated in chronic experiments on rabbits. It was also shown that a new derivative of methylxanthine, which does not penetrate the blood--brain barrier, produces a hypolipidemic and antiatherosclerotic effect. Experiments on rats, guinea pigs, and rabbits with induced hyperlipidemia revealed a hypolipidemic effect of new complex compounds which are not absorbed in the intestine--steroid glycosides digitonin and tomatonin immobilized on a polymer. These substances resemble cholesteramine in activity but are distinguished by solubility, low toxicity, and a mechanism of action which is more physiological.

[Experimental hypolipidemic and antiatherosclerotic activity of bisanions]. / Gipolipidemicheskaia i antiateroskleroticheskaia aktivnost' bisanionov v éksperimente.

Experiments on rabbits with experimental cholesterol atherosclerosis have shown bisanions :formula: see text.

[Effect of the total flavonoids from red clover and chick-pea on the lipid content in the blood and liver of rats]. / Vliianie summy flavonoidov iz klevera krasnogo i nuta obyknovennogo na soderzhanie lipidov v krovi i pecheni krys.

Total flavonoids from clover red and nut, containing isoflavones, decreased the content of cholesterol and triglycerides in intact rats, inhibited the development of hyperlipidemia, caused by Triton WR-1339, prevented accumulation of triglycerides in rat liver and blood caused by ethanol administration. The flavonoids from these plants inhibited lipolysis, stimulated by adrenaline.

[Effect of electrostimulation of the supraoptic region of the hypothalamus on lipid metabolism and the development of atherosclerosis]. / Vliianie élektrostimuliatsii supraopticheskoi oblasti gipotalamusa na lipidnyi obmen i razvitie ateroskleroza.

A three-week electrical stimulation of the hypothalamic supraoptic zone in rabbits which were on atherogenic diet for 3 to 8 weeks accelerated and intensified the development of hypercholesterolemia and lipidosis of the coronary arteries, as well as the metabolic changes in the myocardial tissue. The latter changes were expressed in the reduction of the tissue noradrenaline level, diminution of the creatine phosphate content, and an increase of inorganic phosphorus and lactic acid.

[Effect of chronic stimulation of rats with intact and deafferented hypothalamuses on lipid metabolism and the adrenal cortex]. / Vliianie khronicheskogo razdrazheniia krys s intaktnym i deafferentirovannym gipotalamusom na lipidnyi obmen i koru nadpochechnikov

Chronic irritation of the falsely operated rats and those with the deafferentated hypothalamus led to reduction of total blood cholesterol and the accumulation of triglycerides in the liver. Dexamethasone administration was accompanied by an increase of blood cholesterol and triglycerides and the triglyceride accumulation in the liver. The action of dexamethasone was more pronounced in the animals with the deafferentated hypothalamus. The rate of 11-oxycorticosteroid secretion into the adrenal vein is reduced in the latter.

[Functional state of the hypothalamo-hypophyseo-adrenal system of guinea pigs under the influence of angular acceleration]. / Funktsional'noe sostoianie gipotalamo-gipofizarno-nadpochechnikovoi sistemy morskikh svinok pod vliianiem uglovykh uskorenii

Experiments were conducted on guinea pigs. A study was made of the influence of increased gravitation on the activity of the hypothalamo-hypophysio-adrenal system. It appeared that a single centrifugation led to the activation of the mentioned system; however, repeated action of the angular accelerations on the animal organism failed to lead to any increase in the blood corticosteroid level (on the 6th-11th days); this can be attributed to the adaptation of the central link of the hypophysio-adrenal system to the given stimulus, and not to the exhaustion of the adrenal cortex.