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J Comp Eff Res ; 8(8): 633-643, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31116027

RESUMO

Aim: This study was conducted to determine the potentials of egg lecithin (egg-l) and soy lecithin (soy-l) liposomes in antioxidative and wound healing properties. Materials & methods: The suspensions of egg-l and soy-l were prepared using the fusion technique. The free radical scavenging activity of both lecithin liposomes was evaluated by DPPH and ABTS methods. Tissue staining was used to assess wound-healing parameter. Results: Liposomal lecithins showed an increasing trend of 1-10 mg/ml in radical-scavenging activities (p < 0.0001). Wound-healing assessments showed a significant effect (p < 0.0001) in treatment with topical lecithin liposomes. The results of wound healing also showed better outcomes of egg-l in comparison with phenytoin 1% cream. Conclusion: Antioxidant lecithin liposomes may enhance the treatment of wound injuries.


Assuntos
Antioxidantes/farmacologia , Lecitinas/farmacologia , Lipossomos/farmacologia , Tensoativos/farmacologia , Cicatrização/fisiologia , Animais , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Fibroblastos/efeitos dos fármacos , Masculino , Distribuição Aleatória , Ratos Wistar , Cicatrização/efeitos dos fármacos
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