The rise of medicalization of plants in Brazil: A temporal perspective on vernacular names.

ETHNOPHARMACOLOGICAL RELEVANCE: Brazilian plant species used in folk medicine have acquired several popular names related to commercial medicines in recent decades. This fact has directly effect to the medicalization process. AIM OF THE STUDY: Evaluate the rise of medicalized popular names of medicinal plants in Brazil. MATERIALS AND METHODS: Medicalized popular names of medicinal plants were recorded from 314 ethnobotanical articles in eleven scientific journals published between 1980 and 2017. RESULTS: The review included 141 ethnobotanical articles containing medicalized names from 314 articles consulted. The presence of medicalized names in Brazilian ethnobotanical studies has increased significantly since the 2000s. A total of 85 medicalized popular names were recorded according with phonetic and graphical similarity. The most cited medicalized names were Anador, Insulin, Terramycin, Vick, Novalgin and Penicillin. The prevalence of medicalized name citations in ethnobotanical surveys over non-medicalized names for several species indicates the existence of medicalized plant species. CONCLUSION: Since the 2000s, an increasing number of ethnobotanical studies revealed the appropriation of drug names by folk medicine through the changes of vernacular names of medicinal plants. This medicalization process is mostly related to the expansion of the Brazilian Unified Health System, pharmaceutical industry marketing and Non-Governmental Organizations in the last decades.

Oxidation of monoterpenes in Protium heptaphyllum oleoresins.

Protium heptaphyllum (Burseraceae) oleoresins are rich in volatile monoterpenes, exhibiting a chemical composition that can be strongly altered with time. The present work aimed to discuss the temporal change of the volatile composition of these oleoresins, and search for related supporting evidence. Samples of P. heptaphyllum oleoresin were collected separately for fresh (n = 10) and aged (n = 8) oleoresins, with the essential oils obtained by hydrodistillation analyzed by GC-FID and GC-MS. Fresh oleoresins were characterized by a high content of terpinolene (28.2-69.7%), whereas aged ones contained large amounts of p-cymene (18.7-43.0%) and p-cymen-8-ol (8.2-31.8%). Multivariate analyses were performed based on the yield and major essential oil components to clearly demonstrate the existence of two subsets (fresh and aged oleoresins). In addition, an analysis of the partial genome sequencing of the species was carried out, producing the largest amount of data for the genus Protium. Subsequently, were searched for nucleotide sequences responsible for the enzymes involved in the biosynthesis of monoterpenes. Two hypotheses were formulated to understand the oxidation process during aging of the oleoresins: (i) a natural chemical oxidation of terpenes and (ii) an oxidation catalyzed by enzymes produced by microorganisms associated with the plant. The results suggested that terpinolene was most likely oxidized to p-cymene, which, in turn, was oxidized into p-cymen-8-ol during natural aging of the exudate due to abiotic factors.

In Vitro Antileukemic Activity of Xanthosoma sagittifolium (Taioba) Leaf Extract.

Xanthosoma sagittifolium Schott is a herb of the Araceae family, popularly known as taioba, which is consumed as food in some regions of Brazil, Africa, and Asia. This species has already been evaluated for the antifungal activities. However, based on its potential antitumor activity, the present study further aimed to examine the antitumor, as well as chelation, activity of X. sagittifolium leaf extract. Results showed that hydroethanolic extract of X. sagittifolium leaves (HEXs-L) exhibits cytotoxic effects against the immortalized line of human T-lymphocytic (Jurkat) and myelogenous (K562) leukemia cells, but not nontumor RAW 264.7 macrophages or NIH/3T3 fibroblasts. HEXs-L inhibited 50.3% of Jurkat cell proliferation, reducing by 20% cells in G2/M phase, but increasing cells in sub-G1 phase, thereby inducing apoptosis by 54%. In addition, HEXs-L inhibited NO production by 59%, as determined by Griess reaction, and chelated 93.8% of free Fe(II), as demonstrated by ferrozine assay. Phytochemical studies were carried out by ESI-MS, identifying apigenin di-C-glycosides as major compounds. Overall, this work revealed that leaf extract of Xanthosoma sagittifolium presented chelating activity and in vitro antitumor activity, arresting cell cycle and inducing apoptosis of leukemia cells, thus providing evidence that taioba leaves may have practical application in cancer therapy.